Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Gold Nanoparticles Functionalized with Dendritic Polyglycerol Sulfates

25.01.2013
<strong>Background</strong><br>

As selectins mediate the first contacts of leukocytes to the endothelium, the initial events of all kind of inflammatory responses, selectins are ideal targets for the therapeutic intervention of inflammatory diseases. <br><br> Dendritic polyglycerol sulfates (dPGS) alone and with aminoalcohols functionalized gold nanoparticles each have been shown to be good selectin inhibitors, as they prevent L- and P-selectins to bind their natural ligands with IC50 values in the nanomolar and picomolar range. <br><br>

<strong>Technology</strong><br> We offer synthesized gold nanoparticles functionalized with highly branched polyglycerol sulfates, showing a high affinity for L- and P-selectins with IC50 values in the femtomolar range and therefore having a better anti-inflammatory potential compared to dPGS and aminoalcohol-functionalized nanoparticles alone. <br><br> Besides their use in the therapy of inflammatory diseases, dPGS-functionalized nanoparticles can also be used for diagnostic purposes. By using dPGS functionalized nanoparticles, selectin expressing inflammatory tissues can be localized and visualized. <br><br> <strong>Benefits</strong> <ul> <li>Improved selectin inhibition with IC50 = 180 fM </li> <li>Branched polyglycerols show high biocompatibility</li> <li>Visualization of gold nanoparticles by MRT possible </li> </ul> <p><strong>IP Rights</strong><br> DE patent application filed 05/2011<br> PCT application filed 05/2012 <br><br> <strong>Patent Owner</strong><br> Charité Universitätsmedizin Berlin<br> Freie Universität Berlin</p>

Further Information: PDF

ipal GmbH
Phone: +49 (0)30/2125-4820

Contact
Dr. Dirk Dantz

info@technologieallianz.de | TechnologieAllianz e.V.
Further information:
http://www.technologieallianz.de/angebote.php?sort=sag&id=3024&lang=en
http://www.technologieallianz.de

More articles from Technology Offerings:

nachricht New Lithium Salts of Pentafluorophenylamide Anions as Electrolytes in Lithium Ionic Batteries
18.04.2017 | TechnologieAllianz e.V.

nachricht Gratings on glass surfaces
28.03.2017 | TechnologieAllianz e.V.

All articles from Technology Offerings >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Can we see monkeys from space? Emerging technologies to map biodiversity

An international team of scientists has proposed a new multi-disciplinary approach in which an array of new technologies will allow us to map biodiversity and the risks that wildlife is facing at the scale of whole landscapes. The findings are published in Nature Ecology and Evolution. This international research is led by the Kunming Institute of Zoology from China, University of East Anglia, University of Leicester and the Leibniz Institute for Zoo and Wildlife Research.

Using a combination of satellite and ground data, the team proposes that it is now possible to map biodiversity with an accuracy that has not been previously...

Im Focus: Climate satellite: Tracking methane with robust laser technology

Heatwaves in the Arctic, longer periods of vegetation in Europe, severe floods in West Africa – starting in 2021, scientists want to explore the emissions of the greenhouse gas methane with the German-French satellite MERLIN. This is made possible by a new robust laser system of the Fraunhofer Institute for Laser Technology ILT in Aachen, which achieves unprecedented measurement accuracy.

Methane is primarily the result of the decomposition of organic matter. The gas has a 25 times greater warming potential than carbon dioxide, but is not as...

Im Focus: How protons move through a fuel cell

Hydrogen is regarded as the energy source of the future: It is produced with solar power and can be used to generate heat and electricity in fuel cells. Empa researchers have now succeeded in decoding the movement of hydrogen ions in crystals – a key step towards more efficient energy conversion in the hydrogen industry of tomorrow.

As charge carriers, electrons and ions play the leading role in electrochemical energy storage devices and converters such as batteries and fuel cells. Proton...

Im Focus: A unique data centre for cosmological simulations

Scientists from the Excellence Cluster Universe at the Ludwig-Maximilians-Universität Munich have establised "Cosmowebportal", a unique data centre for cosmological simulations located at the Leibniz Supercomputing Centre (LRZ) of the Bavarian Academy of Sciences. The complete results of a series of large hydrodynamical cosmological simulations are available, with data volumes typically exceeding several hundred terabytes. Scientists worldwide can interactively explore these complex simulations via a web interface and directly access the results.

With current telescopes, scientists can observe our Universe’s galaxies and galaxy clusters and their distribution along an invisible cosmic web. From the...

Im Focus: Scientists develop molecular thermometer for contactless measurement using infrared light

Temperature measurements possible even on the smallest scale / Molecular ruby for use in material sciences, biology, and medicine

Chemists at Johannes Gutenberg University Mainz (JGU) in cooperation with researchers of the German Federal Institute for Materials Research and Testing (BAM)...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Plants are networkers

19.06.2017 | Event News

Digital Survival Training for Executives

13.06.2017 | Event News

Global Learning Council Summit 2017

13.06.2017 | Event News

 
Latest News

Quantum thermometer or optical refrigerator?

23.06.2017 | Physics and Astronomy

A 100-year-old physics problem has been solved at EPFL

23.06.2017 | Physics and Astronomy

Equipping form with function

23.06.2017 | Information Technology

VideoLinks
B2B-VideoLinks
More VideoLinks >>>