GlioMethyl - Promotor methylation of the DUSP-4 gene as predictive parameter for gliomas
Gliomas, especially secondary glioblastomas, are affected
with hypermethylation of the promoter region of the
DUSP4 gene. Further studies have shown a significant
correlation between hypermethylation of DUSP4 and
prolonged survival of glioblastoma patients. Similar
correlation has also been observed with MGMT promoter
methylation and treatment of Glioblastoma patients with
alkylating agents. The present invention therefore
provides a predictive epigenetic parameter for diagnosis
or prognosis of gliomas and may be useful for prediction
of the responsiveness to certain therapies. It further
describes an improved method for the determination of the
promoter methylation, which is applicable for the clinical
This invention provides an opportunity for the
development of therapeutics for secondary glioblastomas.
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