DNA-binding MLW Protein for Specific Gene Targeting
One of the most important requirements for efficient and specific gene targeting is delivering the nucleic acids to the site of interest and keeping them there until editing through the host repair machinery. Although, it is possible to deliver proteins and peptides to specific organelles and DNA regions, it is not possible to deliver nucleic acids to defined genomic DNA regions.
The present invention allows for overcoming this problem by the innovative MLW technology. MLW is a protein, wherein M specifically binds to a donor DNA sequence and W binds to a target DNA sequence. Thereby the donor and target DNA can be brought to close proximity and are immediately available for recombination.
Further Information: PDF
PROvendis GmbH
Phone: +49 (0)208/94105 10
Contact
Dipl.-Ing. Alfred Schillert
Media Contact
All latest news from the category: Technology Offerings
Newest articles
Machine learning algorithm reveals long-theorized glass phase in crystal
Scientists have found evidence of an elusive, glassy phase of matter that emerges when a crystal’s perfect internal pattern is disrupted. X-ray technology and machine learning converge to shed light…
Mapping plant functional diversity from space
HKU ecologists revolutionize ecosystem monitoring with novel field-satellite integration. An international team of researchers, led by Professor Jin WU from the School of Biological Sciences at The University of Hong…
Inverters with constant full load capability
…enable an increase in the performance of electric drives. Overheating components significantly limit the performance of drivetrains in electric vehicles. Inverters in particular are subject to a high thermal load,…