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DNA-binding MLW Protein for Specific Gene Targeting

18.10.2013
One of the most important requirements for efficient and specific gene targeting is delivering the nucleic acids to the site of interest and keeping them there until editing through the host repair machinery. Although, it is possible to deliver proteins and peptides to specific organelles and DNA regions, it is not possible to deliver nucleic acids to defined genomic DNA regions.

The present invention allows for overcoming this problem by the innovative MLW technology. MLW is a protein, wherein M specifically binds to a donor DNA sequence and W binds to a target DNA sequence. Thereby the donor and target DNA can be brought to close proximity and are immediately available for recombination.

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