Direct Programmable Detection of Epigenetic Cytosine Modifications in DNA using TALEs

Epigenetic modifications at the 5-position of cytosine in DNA provide important clues for diseases such as neurological disorders and a range of cancers. Scientists at the University of Constance have now developed a method which allows the direct detection, i.e. without prior chemical modification of the DNA sample, of the epigenetic modification status in the 5-position of cytosine (such as 5mC and 5hmC) in any user-defined sequence. It is a simple and reliable method with high resolution and can be combined with a multitude of detection methods. Detection both in vivo and in vitro is possible.

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