Diagnostic assay for recent flavivirus infections: Zika, Dengue, Tick-borne encephalitis
The assay detects lgM antibodies with high sensitivity and specificity and thus provides a means for the early serological diagnosis of flavivirus infections. lt is based on an lgM-capture format and highly purified recombinant viral antigens, allowing the differentiation between infections with antigenically closely related flaviviruses like dengue and Zika viruses. The lgM-capture format is robust, can be easily standardized and readily adapted to existing diagnostic systems for antibody detection.
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