Corallopyronin A (CorA) has efficacy against the intracellular Wolbachia of filarial nematodes. Experiments in mice show that all worms were depleted of more than 98% of their Wolbachia, resulting in blocked larval development and phenotypically altered worms. The results indicate the potential of CorA to effectively eliminate filarial disease by killing larvae as well as adult worms with one (maximum of two) treatment regimens.
No toxicity against eukaryotic cells was detected. Preliminary pharmacokinetic data show that the antibiotic is amenable to oral administration.
CorA is a non-competitive inhibitor of bacterial DNA-dependent RNA polymerase, with a different mode of action from rifampicin.
Further Information: PDF
Phone: +49 (0)208/94105 10
Dipl.-Ing. Alfred Schillert
firstname.lastname@example.org | TechnologieAllianz e.V.
Synthesis of novel Myrtucommulone and Analogues
25.11.2013 | TechnologieAllianz e.V.
Innovative nozzle design with homogeneous flow profile usable as divergent long-range nozzle with high penetration depth
22.11.2013 | TechnologieAllianz e.V.
08.12.2014 | Event News
01.12.2014 | Event News
21.11.2014 | Event News
19.12.2014 | Earth Sciences
19.12.2014 | Physics and Astronomy
19.12.2014 | Ecology, The Environment and Conservation