Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

CorA as anthelmintic - Natural product as antibiotic for the treatment of dirofilariasis

14.02.2013
Dirofilariasis is caused by Dirofilaria immitis and D. repens, parasitic nematodes, which are transmitted by blood sucking mosquitoes. The heartworms harbour the bacterial endosymbiont Wolbachia, which is essential for worm development, fecundity and survival.

Corallopyronin A (CorA) has efficacy against the intracellular Wolbachia of filarial nematodes. Experiments in mice show that all worms were depleted of more than 98% of their Wolbachia, resulting in blocked larval development and phenotypically altered worms. The results indicate the potential of CorA to effectively kill filarial nematodes in the larval stages as well as adult worms. No toxicity against eukaryotic cells was detected. Preliminary pharmacokinetic data show that the antibiotic is amenable to oral administration. CorA is a non-competitive inhibitor of bacterial DNA-dependent RNA polymerase.

Further Information: PDF

PROvendis GmbH
Phone: +49 (0)208/94105 10

Contact
Dipl.-Ing. Alfred Schillert

info@technologieallianz.de | TechnologieAllianz e.V.
Further information:
http://www.technologieallianz.de/angebote.php?sort=sag&id=2918&lang=en
http://www.technologieallianz.de

More articles from Technology Offerings:

nachricht Synthesis of novel Myrtucommulone and Analogues
25.11.2013 | TechnologieAllianz e.V.

nachricht Innovative nozzle design with homogeneous flow profile usable as divergent long-range nozzle with high penetration depth
22.11.2013 | TechnologieAllianz e.V.

All articles from Technology Offerings >>>

The most recent press releases about innovation >>>

Anzeige

Anzeige

Event News

BrainScaleS Conference: From Neurobiology to New Computer Architectures

25.09.2014 | Event News

17th European Health Forum Gastein: “Electing Health – The Europe We Want”

23.09.2014 | Event News

Future questions regarding data processing

22.09.2014 | Event News

 
Latest News

Stressed Out: Research Sheds New Light on Why Rechargeable Batteries Fail

02.10.2014 | Power and Electrical Engineering

Nanoparticles Accumulate Quickly in Wetland Sediment

02.10.2014 | Ecology, The Environment and Conservation

'Smart' bandage emits phosphorescent glow for healing below

02.10.2014 | Medical Engineering

VideoLinks
B2B-VideoLinks
More VideoLinks >>>