Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

CorA as anthelmintic - Natural product as antibiotic for the treatment of dirofilariasis

14.02.2013
Dirofilariasis is caused by Dirofilaria immitis and D. repens, parasitic nematodes, which are transmitted by blood sucking mosquitoes. The heartworms harbour the bacterial endosymbiont Wolbachia, which is essential for worm development, fecundity and survival.

Corallopyronin A (CorA) has efficacy against the intracellular Wolbachia of filarial nematodes. Experiments in mice show that all worms were depleted of more than 98% of their Wolbachia, resulting in blocked larval development and phenotypically altered worms. The results indicate the potential of CorA to effectively kill filarial nematodes in the larval stages as well as adult worms. No toxicity against eukaryotic cells was detected. Preliminary pharmacokinetic data show that the antibiotic is amenable to oral administration. CorA is a non-competitive inhibitor of bacterial DNA-dependent RNA polymerase.

Further Information: PDF

PROvendis GmbH
Phone: +49 (0)208/94105 10

Contact
Dipl.-Ing. Alfred Schillert

info@technologieallianz.de | TechnologieAllianz e.V.
Further information:
http://www.technologieallianz.de/angebote.php?sort=sag&id=2918&lang=en
http://www.technologieallianz.de

More articles from Technology Offerings:

nachricht Device and process for the agglomeration of colloids
29.07.2015 | TechnologieAllianz e.V.

nachricht Method for rapid optimization of FEBID/FIBID processes
29.07.2015 | TechnologieAllianz e.V.

All articles from Technology Offerings >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Greenhouse gases' millennia-long ocean legacy

Continuing current carbon dioxide (CO2) emission trends throughout this century and beyond would leave a legacy of heat and acidity in the deep ocean. These...

Im Focus: Glaciers melt faster than ever

Glacier decline in the first decade of the 21st century has reached a historical record, since the onset of direct observations. Glacier melt is a global phenomenon and will continue even without further climate change. This is shown in the latest study by the World Glacier Monitoring Service under the lead of the University of Zurich, Switzerland.

The World Glacier Monitoring Service, domiciled at the University of Zurich, has compiled worldwide data on glacier changes for more than 120 years. Together...

Im Focus: Quantum Matter Stuck in Unrest

Using ultracold atoms trapped in light crystals, scientists from the MPQ, LMU, and the Weizmann Institute observe a novel state of matter that never thermalizes.

What happens if one mixes cold and hot water? After some initial dynamics, one is left with lukewarm water—the system has thermalized to a new thermal...

Im Focus: On the crest of the wave: Electronics on a time scale shorter than a cycle of light

Physicists from Regensburg and Marburg, Germany have succeeded in taking a slow-motion movie of speeding electrons in a solid driven by a strong light wave. In the process, they have unraveled a novel quantum phenomenon, which will be reported in the forthcoming edition of Nature.

The advent of ever faster electronics featuring clock rates up to the multiple-gigahertz range has revolutionized our day-to-day life. Researchers and...

Im Focus: Superfast fluorescence sets new speed record

Plasmonic device has speed and efficiency to serve optical computers

Researchers have developed an ultrafast light-emitting device that can flip on and off 90 billion times a second and could form the basis of optical computing.

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Success 4.0 – Is Your Company Fit for the Future? New Series of Events for Executives

04.08.2015 | Event News

3rd Euro Bio-inspired - International Conference and Exhibition on Bio-inspired Materials

23.07.2015 | Event News

Clash of Realities – International Conference on the Art, Technology and Theory of Digital Games

10.07.2015 | Event News

 
Latest News

Small tilt in magnets makes them viable memory chips

04.08.2015 | Information Technology

New Design Brings World’s First Solar Battery to Performance Milestone

04.08.2015 | Power and Electrical Engineering

Magnetism at Nanoscale

04.08.2015 | Materials Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>