Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Compounds activating the glmS riboswitch

19.11.2012
Cyclohexane compounds and their use as antibiotics

Invention The present invention relates to cyclohexane compounds for the treatment of a bacterial infection, particularly for use as an antibiotic.

Since the discovery of antibiotic substances and their use against microbes, bacteria have evolved to defend themselves by acquiring resistances. Especially in hospitals where bacteria are exposed to a wide array of antibacterial substances, multiresistant strains (e.g. MRSA) arose. This is why it is not only necessary to have an ongoing search for new antibiotic substances, but to also find and use new antibacterial targets enforcing new mechanisms of action. Riboswitches have appeared as one new promising target for antibacterial defence. Riboswitches are mostly found in the 5'-untranslated region of bacterial mRNA and regulate 2-4% of all bacterial genes. In the past it has been shown that metabolite analogues can be employed to trigger riboswitch function thereby modulating its regulatory character. Thus, it would be desirable to provide compounds that also target the glmS riboswitch and exhibit antimicrobial activity.

Further Information: PDF

PROvendis GmbH
Phone: +49 (0)208/94105 10

Contact
Dipl.-Ing. Alfred Schillert

info@technologieallianz.de | TechnologieAllianz e.V.
Further information:
http://www.technologieallianz.de/angebote.php?sort=sag&id=2262&lang=en
http://www.technologieallianz.de

More articles from Technology Offerings:

nachricht Synthesis of novel Myrtucommulone and Analogues
25.11.2013 | TechnologieAllianz e.V.

nachricht Innovative nozzle design with homogeneous flow profile usable as divergent long-range nozzle with high penetration depth
22.11.2013 | TechnologieAllianz e.V.

All articles from Technology Offerings >>>

The most recent press releases about innovation >>>

Anzeige

Anzeige

Event News

"Start-ups and spin-offs funding – Public and private policies", 14th October 2014

12.09.2014 | Event News

BALTIC 2014: Baltic Sea Geologists meet in Warnemünde

03.09.2014 | Event News

IT security in the digital society

27.08.2014 | Event News

 
Latest News

Smallest VGA-resolution infrared camera worldwide

17.09.2014 | Press release

And So They Beat on, Flagella Against the Cantilever

17.09.2014 | Physics and Astronomy

Consumers Will Pay More for Eco-Friendly Plants, Study Shows

17.09.2014 | Studies and Analyses

VideoLinks
B2B-VideoLinks
More VideoLinks >>>