Compounds activating the glmS riboswitch
Cyclohexane compounds and their use as antibiotics
The present invention relates to cyclohexane compounds for the treatment of a bacterial infection, particularly for use as an antibiotic.
Since the discovery of antibiotic substances and their use against microbes, bacteria have evolved to defend themselves by acquiring resistances. Especially in hospitals where bacteria are exposed to a wide array of antibacterial substances, multiresistant strains (e.g. MRSA) arose.
This is why it is not only necessary to have an ongoing search for new antibiotic substances, but to also find and use new antibacterial targets enforcing new mechanisms of action.
Riboswitches have appeared as one new promising target for antibacterial defence. Riboswitches are mostly found in the 5'-untranslated region of bacterial mRNA and regulate 2-4% of all bacterial genes. In the past it has been shown that metabolite analogues can be employed to trigger riboswitch function thereby modulating its regulatory character. Thus, it would be desirable to provide compounds that also target the glmS riboswitch and exhibit antimicrobial activity.
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