Combined application of epigenetic modifiers and TALEs
The patented method enables the reactivation of epigenetically-silenced genes. The scientists have discovered a method for removing methyl groups in certain areas of the DNA, which can be used to reactivate epigenetically-silenced genes. While known transcription factors (proteins that bind to the DNA and switch a gene on via a promoter) like TALEs or zinc fingers already dock at certain gene sections of the DNA, this has not been possible up to now in the case of epigenetically-silenced gene sequences. This problem has now been solved through the addition of valproic acid (VPA 10) and a HDAC inhibitor. This measure made it possible to “open” the packaging of the epigenetically-silenced gene sequences, which consists of HDAC (histone deacetylases), making them accessible to the transcription factors.
Further Information: PDF
Bayerische Patentallianz GmbH
Phone: +49 89 5480177-0
Contact
Peer Biskup
Media Contact
All latest news from the category: Technology Offerings
Newest articles
Machine learning algorithm reveals long-theorized glass phase in crystal
Scientists have found evidence of an elusive, glassy phase of matter that emerges when a crystal’s perfect internal pattern is disrupted. X-ray technology and machine learning converge to shed light…
Mapping plant functional diversity from space
HKU ecologists revolutionize ecosystem monitoring with novel field-satellite integration. An international team of researchers, led by Professor Jin WU from the School of Biological Sciences at The University of Hong…
Inverters with constant full load capability
…enable an increase in the performance of electric drives. Overheating components significantly limit the performance of drivetrains in electric vehicles. Inverters in particular are subject to a high thermal load,…