<p> Superior solubilization of hydrophobic drugs in aqueous solution can be achieved with a novel amphiphilic polymer. The invention utilizes non-toxic polymers for solubilizing hydrophobic drugs by means of defined polymeric micelles. The resulting nanoformulation increases the innate solubility in aqueous solution by 4 orders of magnitude and has a very high loading capacity of up to 40% wt that allows for solubilization of e.g. 8 mg/mL paclitaxel in water. <p> The annual worldwide sales of the few highly hydrophobic drugs that have been successfully solubilized sum up to several billion dollars. The use of this novel carrier system will enable the successful development of numerous APIs into potent drugs, which has an even higher commercial potential. <p>
email@example.com | TechnologieAllianz e.V.
Phase-separation cell 1: Measurement equipment for liquid/liquid dispersion and separation processes in centrifugal field
13.01.2017 | TechnologieAllianz e.V.
Phase-separation cell 2: Liquid/liquid dispersion, reaction and separation processes in centrifugal field in one device as one closed batch process
13.01.2017 | TechnologieAllianz e.V.
Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.
While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...
Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales
Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...
Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.
As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...
At TU Wien, an alternative for resource intensive formwork for the construction of concrete domes was developed. It is now used in a test dome for the Austrian Federal Railways Infrastructure (ÖBB Infrastruktur).
Concrete shells are efficient structures, but not very resource efficient. The formwork for the construction of concrete domes alone requires a high amount of...
Many pathogens use certain sugar compounds from their host to help conceal themselves against the immune system. Scientists at the University of Bonn have now, in cooperation with researchers at the University of York in the United Kingdom, analyzed the dynamics of a bacterial molecule that is involved in this process. They demonstrate that the protein grabs onto the sugar molecule with a Pac Man-like chewing motion and holds it until it can be used. Their results could help design therapeutics that could make the protein poorer at grabbing and holding and hence compromise the pathogen in the host. The study has now been published in “Biophysical Journal”.
The cells of the mouth, nose and intestinal mucosa produce large quantities of a chemical called sialic acid. Many bacteria possess a special transport system...
10.01.2017 | Event News
09.01.2017 | Event News
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17.01.2017 | Earth Sciences
17.01.2017 | Materials Sciences
17.01.2017 | Architecture and Construction