Current methods to diagnose Alzheimer´s Disease (AD) comprise computer tomography (CT), magnet resonance imaging (MRI) or positron emission tomography (PET) visualizing abnormalities in the brain. Other approaches concerns to the determination of biomarkers such as tau/ phospho-tau or beta Amyloid in body fluids (blood, liquor). However, CSF level of tau is a general marker for neuronal dysfunction and not specific for AD alone (also increased in Creutzfeldt Jacob). In AD patients, decreased levels of Abeta42 could be shown, however the values of concentrations in various AD patients differ dramatically so that Abeta42 alone is not a sufficient reliable marker. Furthermore Abeta42 seems to be decreased only in patients who already have clinical symptoms of AD. It is a strong medical need for diagnostic markers which are able to predict AD at a very early stage before clinical symptoms occur. This would allow earlier treatments before neuronal damage starts. <br><br> <strong>Technology</strong><br> We offer a novel approach for the early recognition of pre-symptomatic stages of AD even 20-30 years before clinical changes/ symptoms like mild cognitive impairment (MCI) or AD occur. The assay is based on the detection of the Aß38:Aß42 concentration ratio. A decrease of the Aß38:Aß42 ratio (value <1,5) in a phenotypically healthy, pre-symptomatic person is hypothized to be indicative that this person will develop MCI and AD later in life. This statement is based on findings in the human neuroblastoma cell line SHSY5Y stably expressing APP by investigating the expression and procession of AAP and is further based on postulating a gamma-secretase cleavage mechanism of APP-TMS (TM: transmembrane).<br><br>
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Flexible and rigid, heavy-metal free organic redox polymer batteries
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Quat primer polymers the universal key to permanent surface functionalization
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Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.
The results will be published on March 22 in the journal „Astronomy & Astrophysics“.
Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...
Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.
Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...
In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...
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24.03.2017 | Physics and Astronomy