Current methods to diagnose Alzheimer´s Disease (AD) comprise computer tomography (CT), magnet resonance imaging (MRI) or positron emission tomography (PET) visualizing abnormalities in the brain. Other approaches concerns to the determination of biomarkers such as tau/ phospho-tau or beta Amyloid in body fluids (blood, liquor). However, CSF level of tau is a general marker for neuronal dysfunction and not specific for AD alone (also increased in Creutzfeldt Jacob). In AD patients, decreased levels of Abeta42 could be shown, however the values of concentrations in various AD patients differ dramatically so that Abeta42 alone is not a sufficient reliable marker. Furthermore Abeta42 seems to be decreased only in patients who already have clinical symptoms of AD. It is a strong medical need for diagnostic markers which are able to predict AD at a very early stage before clinical symptoms occur. This would allow earlier treatments before neuronal damage starts. <br><br> <strong>Technology</strong><br> We offer a novel approach for the early recognition of pre-symptomatic stages of AD even 20-30 years before clinical changes/ symptoms like mild cognitive impairment (MCI) or AD occur. The assay is based on the detection of the Aß38:Aß42 concentration ratio. A decrease of the Aß38:Aß42 ratio (value <1,5) in a phenotypically healthy, pre-symptomatic person is hypothized to be indicative that this person will develop MCI and AD later in life. This statement is based on findings in the human neuroblastoma cell line SHSY5Y stably expressing APP by investigating the expression and procession of AAP and is further based on postulating a gamma-secretase cleavage mechanism of APP-TMS (TM: transmembrane).<br><br>
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Dosing system of bulk material (granulates) for expansion injection molding
19.01.2017 | TechnologieAllianz e.V.
Efficient method for Chain Multiplication of unsaturated fatty acids - synthesis of ultra long-chain compounds
18.01.2017 | TechnologieAllianz e.V.
An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...
Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...
Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.
While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...
Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales
Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...
Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.
As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...
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