Current methods to diagnose Alzheimer´s Disease (AD) comprise computer tomography (CT), magnet resonance imaging (MRI) or positron emission tomography (PET) visualizing abnormalities in the brain. Other approaches concerns to the determination of biomarkers such as tau/ phospho-tau or beta Amyloid in body fluids (blood, liquor). However, CSF level of tau is a general marker for neuronal dysfunction and not specific for AD alone (also increased in Creutzfeldt Jacob). In AD patients, decreased levels of Abeta42 could be shown, however the values of concentrations in various AD patients differ dramatically so that Abeta42 alone is not a sufficient reliable marker. Furthermore Abeta42 seems to be decreased only in patients who already have clinical symptoms of AD. It is a strong medical need for diagnostic markers which are able to predict AD at a very early stage before clinical symptoms occur. This would allow earlier treatments before neuronal damage starts. <br><br> <strong>Technology</strong><br> We offer a novel approach for the early recognition of pre-symptomatic stages of AD even 20-30 years before clinical changes/ symptoms like mild cognitive impairment (MCI) or AD occur. The assay is based on the detection of the Aß38:Aß42 concentration ratio. A decrease of the Aß38:Aß42 ratio (value <1,5) in a phenotypically healthy, pre-symptomatic person is hypothized to be indicative that this person will develop MCI and AD later in life. This statement is based on findings in the human neuroblastoma cell line SHSY5Y stably expressing APP by investigating the expression and procession of AAP and is further based on postulating a gamma-secretase cleavage mechanism of APP-TMS (TM: transmembrane).<br><br>
firstname.lastname@example.org | TechnologieAllianz e.V.
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The more electronics steer, accelerate and brake cars, the more important it is to protect them against cyber-attacks. That is why 15 partners from industry and academia will work together over the next three years on new approaches to IT security in self-driving cars. The joint project goes by the name Security For Connected, Autonomous Cars (SecForCARs) and has funding of €7.2 million from the German Federal Ministry of Education and Research. Infineon is leading the project.
Vehicles already offer diverse communication interfaces and more and more automated functions, such as distance and lane-keeping assist systems. At the same...
A research team led by physicists at the Technical University of Munich (TUM) has developed molecular nanoswitches that can be toggled between two structurally different states using an applied voltage. They can serve as the basis for a pioneering class of devices that could replace silicon-based components with organic molecules.
The development of new electronic technologies drives the incessant reduction of functional component sizes. In the context of an international collaborative...
At the LASYS 2018, from June 5th to 7th, the Laser Zentrum Hannover e.V. (LZH) will be showcasing processes for the laser material processing of tomorrow in hall 4 at stand 4E75. With blown bomb shells the LZH will present first results of a research project on civil security.
At this year's LASYS, the LZH will exhibit light-based processes such as cutting, welding, ablation and structuring as well as additive manufacturing for...
There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?
At Display Week 2018, scientists from the Fraunhofer Institute for Applied Polymer Research IAP will be demonstrating today’s technological possibilities and...
So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics
Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...
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