Genotyping of this SNP might allow identifying responders and non-responders under therapy which affect the renin-angiotensin system (e.g. renin, aldosteron or ACE inhibitors or angiotnsin receptor blockers). The AQP5-SNP will also be useful in the identification of new drug targets. As many drugs act on or at least influence signal transduction and water homeostasis, prediction of the efficacy and adverse effects as well as dose adjustments of numerous drugs is possible. Thus the AQP5-SNP will also be valuable for personalized medicine.
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