Novel high affinity aptamers have been selected which inhibit the agonistic effect of autoantibodies specific for the second extracellular loop of human beta1-adrenergic receptors. Antibodies to the beta1-adrenergic receptor are detected in approximately 70% of idiopathic dilated cardiomyopathy patients and in nearly 100% of patients with Chagas’ cardiomyopathy and peripartum cardiomyopathy. The typical characteristics of these heart muscle disorders are ventricle enlargement and the inability to pump enough blood for the body's needs and finally severe heart failure. <br> The novel aptamers strongly inhibit the agonistic effect of beta1-adrenergic receptor-directed autoantibodies isolated from patients with idiopatic dilated cardiomyopathy, Chagas’ cardiomyopathy and peripartum cardiomyopathy, as demonstrated in a bioassay analyzing the beating frequency of rat cardiomyocytes. The specificity of the new aptamers to the autoantibodies relevant for the indicated cardiomyopathies has potential in the development of valuable new agents for diagnostic and therapeutic applications. </p> <b>Benefits:</b>
firstname.lastname@example.org | TechnologieAllianz e.V.
New Lithium Salts of Pentafluorophenylamide Anions as Electrolytes in Lithium Ionic Batteries
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Study published in the journal ACS Applied Materials & Interfaces is the outcome of an international effort that included teams from Dresden and Berlin in Germany, and the US.
Scientists at the Helmholtz-Zentrum Dresden-Rossendorf (HZDR) together with colleagues from the Helmholtz-Zentrum Berlin (HZB) and the University of Virginia...
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