We offer the new application of the known thrombin aptamer Arc183– initially developed as a anticoagulant for thrombin inhibition – for the highly specific binding and neutralization of autoantibodies against G-protein coupled receptors (AAB) such as adrenergic alpha-1-, adrenergic beta-1- and beta-2 receptors, the endothelin 1 ETA receptor, the muscarinic M2 receptor, the angiotensin II AT1 receptor, and/or the PAR receptors. These AABs are not only present in defined cardiovascular diseases (e.g. idiopathic dilated cardiomyopathy, Chagas’ cardiomyopathy, peripartum cardiomyopathy, myocarditis, hypertension, pulmonary hypertension and malignant hypertension) but they are also present in other diseases, e.g. Chagas’ megacolon, Chagas’ megaoesophagus, Chagas’ neuropathy, glaucoma, diabetes mellitus, Alzheimer’s disease, benign prostatic hyperplasia, psoriasis, scleroderma, Raynauld’s syndrome and kidney allograft rejection. The pathogenetic function of the AABs is well documented, especially for cardiomyopathies and kidney rejection, and the removal of AABs by apheresis and treatments for AAB neutralization are under investigation. The aptamer strongly inhibits the agonistic effect of patients’ AABs via their detected function, as demonstrated in a bioassay that analysed the beating frequency of rat cardiomyocytes. The aptamer was also found to clear human serum of AABs when coupled to an apheresis column. <br><br> <b>Benefits:</b><ul> <li>Novel second medical indication for the thrombin aptamer Arc 183</li> <li>Possible therapeutic applications in diseases positive for AABs against G-protein coupled receptors </li>
email@example.com | TechnologieAllianz e.V.
New Lithium Salts of Pentafluorophenylamide Anions as Electrolytes in Lithium Ionic Batteries
18.04.2017 | TechnologieAllianz e.V.
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Staphylococcus aureus is a feared pathogen (MRSA, multi-resistant S. aureus) due to frequent resistances against many antibiotics, especially in hospital infections. Researchers at the Paul-Ehrlich-Institut have identified immunological processes that prevent a successful immune response directed against the pathogenic agent. The delivery of bacterial proteins with RNA adjuvant or messenger RNA (mRNA) into immune cells allows the re-direction of the immune response towards an active defense against S. aureus. This could be of significant importance for the development of an effective vaccine. PLOS Pathogens has published these research results online on 25 May 2017.
Staphylococcus aureus (S. aureus) is a bacterium that colonizes by far more than half of the skin and the mucosa of adults, usually without causing infections....
Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.
The quantum computer has fuelled the imagination of scientists for decades: It is based on fundamentally different phenomena than a conventional computer....
An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.
We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...
Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.
Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...
An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...
24.05.2017 | Event News
23.05.2017 | Event News
22.05.2017 | Event News
26.05.2017 | Life Sciences
26.05.2017 | Life Sciences
26.05.2017 | Physics and Astronomy