Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Aptameres for Treatment and Diagnosis of Diseases Seropositive for Autoantibodies

12.09.2012
<strong>Technology</strong><br>

We offer the new application of the known thrombin aptamer Arc183– initially developed as a anticoagulant for thrombin inhibition – for the highly specific binding and neutralization of autoantibodies against G-protein coupled receptors (AAB) such as adrenergic alpha-1-, adrenergic beta-1- and beta-2 receptors, the endothelin 1 ETA receptor, the muscarinic M2 receptor, the angiotensin II AT1 receptor, and/or the PAR receptors. These AABs are not only present in defined cardiovascular diseases (e.g. idiopathic dilated cardiomyopathy, Chagas’ cardiomyopathy, peripartum cardiomyopathy, myocarditis, hypertension, pulmonary hypertension and malignant hypertension) but they are also present in other diseases, e.g. Chagas’ megacolon, Chagas’ megaoesophagus, Chagas’ neuropathy, glaucoma, diabetes mellitus, Alzheimer’s disease, benign prostatic hyperplasia, psoriasis, scleroderma, Raynauld’s syndrome and kidney allograft rejection. The pathogenetic function of the AABs is well documented, especially for cardiomyopathies and kidney rejection, and the removal of AABs by apheresis and treatments for AAB neutralization are under investigation. The aptamer strongly inhibits the agonistic effect of patients’ AABs via their detected function, as demonstrated in a bioassay that analysed the beating frequency of rat cardiomyocytes. The aptamer was also found to clear human serum of AABs when coupled to an apheresis column. <br><br> <b>Benefits:</b><ul> <li>Novel second medical indication for the thrombin aptamer Arc 183</li> <li>Possible therapeutic applications in diseases positive for AABs against G-protein coupled receptors </li>

<li>IC50 values of 100 nM or less in a rat cardiomyocyte beating assay</li> <li>Suitable as specific binder in apheresis: An alternative to the costly and risky apheresis process based on unspecific immunoadsorption </li></ul> <p><strong>IP Rights</strong><br> European patent applic.and US provisional applic. (07/2011)<br> PCT Application (02/2012) <br><br> <strong>Patent Owner</strong><br> Charité - Universitätsmedizin Berlin<br> Max-Delbrück – Centrum für Moleku-lare Medizin Berlin-Buch

Further Information: PDF

ipal GmbH
Phone: +49 (0)30/2125-4820

Contact
Dr. Dirk Dantz

info@technologieallianz.de | TechnologieAllianz e.V.
Further information:
http://www.technologieallianz.de/angebote.php?sort=sag&id=2864&lang=en
http://www.technologieallianz.de

More articles from Technology Offerings:

nachricht New Lithium Salts of Pentafluorophenylamide Anions as Electrolytes in Lithium Ionic Batteries
18.04.2017 | TechnologieAllianz e.V.

nachricht Gratings on glass surfaces
28.03.2017 | TechnologieAllianz e.V.

All articles from Technology Offerings >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Ultrafast snapshots of relaxing electrons in solids

Using ultrafast flashes of laser and x-ray radiation, scientists at the Max Planck Institute of Quantum Optics (Garching, Germany) took snapshots of the briefest electron motion inside a solid material to date. The electron motion lasted only 750 billionths of the billionth of a second before it fainted, setting a new record of human capability to capture ultrafast processes inside solids!

When x-rays shine onto solid materials or large molecules, an electron is pushed away from its original place near the nucleus of the atom, leaving a hole...

Im Focus: Quantum Sensors Decipher Magnetic Ordering in a New Semiconducting Material

For the first time, physicists have successfully imaged spiral magnetic ordering in a multiferroic material. These materials are considered highly promising candidates for future data storage media. The researchers were able to prove their findings using unique quantum sensors that were developed at Basel University and that can analyze electromagnetic fields on the nanometer scale. The results – obtained by scientists from the University of Basel’s Department of Physics, the Swiss Nanoscience Institute, the University of Montpellier and several laboratories from University Paris-Saclay – were recently published in the journal Nature.

Multiferroics are materials that simultaneously react to electric and magnetic fields. These two properties are rarely found together, and their combined...

Im Focus: Fast, convenient & standardized: New lab innovation for automated tissue engineering & drug

MBM ScienceBridge GmbH successfully negotiated a license agreement between University Medical Center Göttingen (UMG) and the biotech company Tissue Systems Holding GmbH about commercial use of a multi-well tissue plate for automated and reliable tissue engineering & drug testing.

MBM ScienceBridge GmbH successfully negotiated a license agreement between University Medical Center Göttingen (UMG) and the biotech company Tissue Systems...

Im Focus: Silencing bacteria

HZI researchers pave the way for new agents that render hospital pathogens mute

Pathogenic bacteria are becoming resistant to common antibiotics to an ever increasing degree. One of the most difficult germs is Pseudomonas aeruginosa, a...

Im Focus: Artificial Enzymes for Hydrogen Conversion

Scientists from the MPI for Chemical Energy Conversion report in the first issue of the new journal JOULE.

Cell Press has just released the first issue of Joule, a new journal dedicated to sustainable energy research. In this issue James Birrell, Olaf Rüdiger,...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

“Lasers in Composites Symposium” in Aachen – from Science to Application

19.09.2017 | Event News

I-ESA 2018 – Call for Papers

12.09.2017 | Event News

EMBO at Basel Life, a new conference on current and emerging life science research

06.09.2017 | Event News

 
Latest News

“Lasers in Composites Symposium” in Aachen – from Science to Application

19.09.2017 | Event News

New quantum phenomena in graphene superlattices

19.09.2017 | Physics and Astronomy

A simple additive to improve film quality

19.09.2017 | Power and Electrical Engineering

VideoLinks
B2B-VideoLinks
More VideoLinks >>>