Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Application of Nanocarriers for the Treatment of Copper-deficiency Diseases

12.09.2012
</a><strong>Background</strong><br>

For several human diseases that are associated with a disturbed cellular metal-ion homeostasis, nanocarriers offer a possibility to bypass the metal-ion uptake system and thereby to rescue the effects of cellular deficiencies. The disadvantage of conventional carriers with limited matrix compatibility is that they either transport non-polar molecules into an aqueous environment or they transfer polar molecules into a hydrophobic environment (micelle). To overcome these problems of solubility and stability of active agents, nanocompartments are needed, that are compatible with various environ-ments.<br><br> <strong>Technology</strong><br> The invention offers a novel application of nanocarriers in copper-deficiency diseases, such as Alzheimer’s and Parkinson Disease. The nano-transport system can deliver copper and other divalent metal-ions with a high specifici-ty. The nanocarriers are formed by covalent modification of dendritic macro-molecules with a shell, to form stable micelle-type structures.<br><br>

<b>Benefits:</b><ul> <li>Nanocarriers with dendritic core and multishell architecture: suitable for non-covalent encapsulation of various guest molecules, compatible with different environments, targeting the nucleus across cell membranes </li> <li>Transport via passage of the blood-brain barrier in a living individual seems to be possible.</li> <li>Bypassing the cellular metal-ion uptake system to rescue the effects of Copper deficiency in certain diseases, such as Alzheimer‘s and Parkinson Diseases.</li> <li>Also diseases associated with other divalent metal ion deficiencies, e.g. Zinc, could be targeted.</li> </ul> <p><strong>IP Rights</strong><br> European patent granted in 2011<br> validated in: DE, CH, DK, ES, FR; GB, IE, IT LI, NL<br> US patent application filed in 02/2008 <br><br> <strong>Patent Owner</strong><br> Freie Universität Berlin

Further Information: PDF

ipal GmbH
Phone: +49 (0)30/2125-4820

Contact
Dr. Dirk Dantz

info@technologieallianz.de | TechnologieAllianz e.V.
Further information:
http://www.technologieallianz.de/angebote.php?sort=sag&id=2861&lang=en
http://www.technologieallianz.de

More articles from Technology Offerings:

nachricht New Lithium Salts of Pentafluorophenylamide Anions as Electrolytes in Lithium Ionic Batteries
18.04.2017 | TechnologieAllianz e.V.

nachricht Gratings on glass surfaces
28.03.2017 | TechnologieAllianz e.V.

All articles from Technology Offerings >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Spider silk key to new bone-fixing composite

University of Connecticut researchers have created a biodegradable composite made of silk fibers that can be used to repair broken load-bearing bones without the complications sometimes presented by other materials.

Repairing major load-bearing bones such as those in the leg can be a long and uncomfortable process.

Im Focus: Writing and deleting magnets with lasers

Study published in the journal ACS Applied Materials & Interfaces is the outcome of an international effort that included teams from Dresden and Berlin in Germany, and the US.

Scientists at the Helmholtz-Zentrum Dresden-Rossendorf (HZDR) together with colleagues from the Helmholtz-Zentrum Berlin (HZB) and the University of Virginia...

Im Focus: Gamma-ray flashes from plasma filaments

Novel highly efficient and brilliant gamma-ray source: Based on model calculations, physicists of the Max PIanck Institute for Nuclear Physics in Heidelberg propose a novel method for an efficient high-brilliance gamma-ray source. A giant collimated gamma-ray pulse is generated from the interaction of a dense ultra-relativistic electron beam with a thin solid conductor. Energetic gamma-rays are copiously produced as the electron beam splits into filaments while propagating across the conductor. The resulting gamma-ray energy and flux enable novel experiments in nuclear and fundamental physics.

The typical wavelength of light interacting with an object of the microcosm scales with the size of this object. For atoms, this ranges from visible light to...

Im Focus: Basel researchers succeed in cultivating cartilage from stem cells

Stable joint cartilage can be produced from adult stem cells originating from bone marrow. This is made possible by inducing specific molecular processes occurring during embryonic cartilage formation, as researchers from the University and University Hospital of Basel report in the scientific journal PNAS.

Certain mesenchymal stem/stromal cells from the bone marrow of adults are considered extremely promising for skeletal tissue regeneration. These adult stem...

Im Focus: Like a wedge in a hinge

Researchers lay groundwork to tailor drugs for new targets in cancer therapy

In the fight against cancer, scientists are developing new drugs to hit tumor cells at so far unused weak points. Such a “sore spot” is the protein complex...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

Unique scope of UV LED technologies and applications presented in Berlin: ICULTA-2018

12.04.2018 | Event News

IWOLIA: A conference bringing together German Industrie 4.0 and French Industrie du Futur

09.04.2018 | Event News

 
Latest News

Magnetic nano-imaging on a table top

20.04.2018 | Physics and Astronomy

Start of work for the world's largest electric truck

20.04.2018 | Interdisciplinary Research

Atoms may hum a tune from grand cosmic symphony

20.04.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>