Application of Nanocarriers for the Treatment of Copper-deficiency Diseases
For several human diseases that are associated with a disturbed cellular metal-ion homeostasis, nanocarriers offer a possibility to bypass the metal-ion uptake system and thereby to rescue the effects of cellular deficiencies. The disadvantage of conventional carriers with limited matrix compatibility is that they either transport non-polar molecules into an aqueous environment or they transfer polar molecules into a hydrophobic environment (micelle). To overcome these problems of solubility and stability of active agents, nanocompartments are needed, that are compatible with various environ-ments.<br><br>
The invention offers a novel application of nanocarriers in copper-deficiency diseases, such as Alzheimer’s and Parkinson Disease. The nano-transport system can deliver copper and other divalent metal-ions with a high specifici-ty. The nanocarriers are formed by covalent modification of dendritic macro-molecules with a shell, to form stable micelle-type structures.<br><br>
<li>Nanocarriers with dendritic core and multishell architecture: suitable for non-covalent encapsulation of various guest molecules, compatible with different environments, targeting the nucleus across cell membranes </li>
<li>Transport via passage of the blood-brain barrier in a living individual seems to be possible.</li>
<li>Bypassing the cellular metal-ion uptake system to rescue the effects of Copper deficiency in certain diseases, such as Alzheimer‘s and Parkinson Diseases.</li>
<li>Also diseases associated with other divalent metal ion deficiencies, e.g. Zinc, could be targeted.</li>
European patent granted in 2011<br>
validated in: DE, CH, DK, ES, FR; GB, IE, IT LI, NL<br>
US patent application filed in 02/2008
Freie Universität Berlin
Further Information: PDF
Phone: +49 (0)30/2125-4820
Dr. Dirk Dantz
firstname.lastname@example.org | TechnologieAllianz e.V.
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