A Copper Complex as Anti-Tumor Agents
There is still a considerable demand for the improvement of cytotoxic cancer
therapeutics regarding the toxicity and the tolerance. While platinum-based
chemotherapy is the standard of care for patients with lung cancer, other
metal-containing agents could not be established in the treatment of cancer
Therefore, we offer a novel copper-based compound, displaying strong and
selective anti-tumor activity in a broad range of hematological cancers and
solid tumors, high efficiency against relapse, improved tolerance and reduced
In vitro studies revealed strong apoptotic and anti-proliferative effects of metal-
organic copper sarcolysin (MOC*Scr) in comparison to other cytotoxic
drugs. When combined with other cytotoxic drugs, MOC*Scr showed strong
synergistic effects pointing towards a different mechanism. Furthermore,
MOC*Scr demonstrated potent activity in cell lines resistant to other standard
drugs such as Vincristin, Daunorubicin and Doxorubicin. Additional in vivo
studies revealed that the MOC*Src treatment leads to significant tumor
growth reduction of 60-90% in syngenic and xenograft tumor models. Also
terminal stage IV patients benefited from the treatment with MOC compound
in investigator initiated trials.<br><br>
Thus, these results position MOC*Scr as an exciting new cancer therapeutic
<li>Excellent anti-tumor activity and synergistic effect with other cytotoxic
<li>Wide spectrum of application including solid tumors and hematological
<li>Overcomes resistances ex vivo</li>
<li>Convenient oral administration</li>
<li>Small molecule with short and simple synthesis</li></ul>
EP and PCT (DE, EP, AU, BR, CA,
CN, IN, JP, RU, US) application filed
in February 2008 and February 2009
Technology Development Funds of
Further Information: PDF
Phone: +49 (0)30/2125-4820
Dr. Dirk Dantz
email@example.com | TechnologieAllianz e.V.
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