Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Asthma patients’ immune systems respond differently with allergies

04.04.2005


Researchers from the University of Chihuahua in Mexico report that immune systems of patients with asthma responded differently to a common laboratory challenge, depending on whether their white blood cells had been obtained during a time when they were suffering from common season allergic rhinitis or when they were free of such allergic symptoms.



The study was presented by Dr. Irene Leal-Berumen on Saturday, April 2, at The American Association of Immunologists scientific sessions during Experimental Biology 2005 in San Diego. She says the findings are an important first step to personalizing treatments for allergy and asthma, both worldwide diseases that interfere with life quality and generate high economic burden.

Asthma is a chronic obstructive inflammatory lung disease with symptoms including wheezing, coughing, chest tightness, and shortness of breath. Asthma attacks can be triggered by viral upper respiratory infections, exercise, extreme temperature condition, and chemical irritants – and also by the same allergens that cause seasonal allergies to pollen or mold spore or perennial allergies to dust mites, cockroaches, feathers, animal fur and other allergens. In fact, the vast majority of patients with asthma also experience one or both of these forms of allergy, with the same symptoms of frequent sneezing, itchy eyes, runny nose and nasal stuffiness.


In people with and without asthma, the body’s response to allergens is based in the leukocytes, or white blood cells, that rush to defend the body against foreign agents. The leukocytes produce cytokines that mediate and regulate immunity and inflammation to an immune stimulus. Because people with asthma and allergy share this common etiological pathway, they show different expressions of their disease with a wide variety of therapeutic responses. That’s why Dr. Leal-Berumen’s laboratory became interested in studying the different response of these cytokines in asthma patients when they were and were not experiencing allergies.

The study involved 10 patients with clinical diagnosis for allergic rhinitis, who also have or had had asthma. Peripheral blood leucocytes were obtained both during rhinitis symptoms and during a period when the patients were not experiencing rhinitis symptoms, then cultured with a type of prostaglandin, a substance that causes inflammation. In nine of the ten asthma patients, leucocytes produced a greater amount of the cytokine IL-5 when isolated during the no symptoms season, whereas five of the nine showed a greater production of IL-13, another cytokine, during the symptoms season. These results indicate that leucocytes from the same patient present different susceptibility to IL-5 and IL-13 production depending on the presence or absence of allergic rhinitis symptoms.

Dr. Leal-Berumen says the group now plans to study cell response to more specific allergens similar to what was done with the prostaglandin challenge. They believe these studies will contribute to a better understanding of asthma, allergy and other inflammatory disease and guide the pharmacogenetic development of new therapies.

Dr. Leal-Berumen’s coauthors are Drs. Elsa Sanchez, Maria Cepeda, Aleli Valenzuela, and Maria de la Luz Arevalo. The study received funding from the University of Chihuahua and from its own researchers.

Sarah Goodwin | EurekAlert!
Further information:
http://www.faseb.org

More articles from Statistics:

nachricht 3% more academic staff at higher education institutions
03.07.2015 | Statistisches Bundesamt

nachricht Number of habilitations up 4% in 2014
17.06.2015 | Statistisches Bundesamt

All articles from Statistics >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: On the crest of the wave: Electronics on a time scale shorter than a cycle of light

Physicists from Regensburg and Marburg, Germany have succeeded in taking a slow-motion movie of speeding electrons in a solid driven by a strong light wave. In the process, they have unraveled a novel quantum phenomenon, which will be reported in the forthcoming edition of Nature.

The advent of ever faster electronics featuring clock rates up to the multiple-gigahertz range has revolutionized our day-to-day life. Researchers and...

Im Focus: Superfast fluorescence sets new speed record

Plasmonic device has speed and efficiency to serve optical computers

Researchers have developed an ultrafast light-emitting device that can flip on and off 90 billion times a second and could form the basis of optical computing.

Im Focus: Unlocking the rice immune system

Joint BioEnergy Institute study identifies bacterial protein that is key to protecting rice against bacterial blight

A bacterial signal that when recognized by rice plants enables the plants to resist a devastating blight disease has been identified by a multi-national team...

Im Focus: Smarter window materials can control light and energy

Researchers in the Cockrell School of Engineering at The University of Texas at Austin are one step closer to delivering smart windows with a new level of energy efficiency, engineering materials that allow windows to reveal light without transferring heat and, conversely, to block light while allowing heat transmission, as described in two new research papers.

By allowing indoor occupants to more precisely control the energy and sunlight passing through a window, the new materials could significantly reduce costs for...

Im Focus: Simulations lead to design of near-frictionless material

Argonne scientists used Mira to identify and improve a new mechanism for eliminating friction, which fed into the development of a hybrid material that exhibited superlubricity at the macroscale for the first time. Argonne Leadership Computing Facility (ALCF) researchers helped enable the groundbreaking simulations by overcoming a performance bottleneck that doubled the speed of the team's code.

While reviewing the simulation results of a promising new lubricant material, Argonne researcher Sanket Deshmukh stumbled upon a phenomenon that had never been...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

3rd Euro Bio-inspired - International Conference and Exhibition on Bio-inspired Materials

23.07.2015 | Event News

Clash of Realities – International Conference on the Art, Technology and Theory of Digital Games

10.07.2015 | Event News

World Conference on Regenerative Medicine in Leipzig: Last chance to submit abstracts until 2 July

25.06.2015 | Event News

 
Latest News

Surprising similarity in fly and mouse motion vision

30.07.2015 | Life Sciences

Efficient Infrared Heat Saves Time and Energy in the Manufacture of Motor Vehicle Carpets

30.07.2015 | Trade Fair News

Roentgen prize goes to Dr Eleftherios Goulielmakis

30.07.2015 | Awards Funding

VideoLinks
B2B-VideoLinks
More VideoLinks >>>