Long-lasting depot medication appears safe and effective for treatment of narcotic addiction
A study in the January issue of the journal Drug and Alcohol Dependence reports that a long-lasting depot medication appears safe and effective for treatment of narcotic addiction. In the study a single injection prevented withdrawal discomfort for 6 weeks in heroin-dependent patients, reduced the effects of injected opiates, and provided a comfortable detoxification as it gradually wore off.
The study medication was an experimental injectable sustained-release depot formulation of the medication buprenorphine. The injection is a suspension of biodegradable microcapsules each containing small amounts of the buprenorphine medication. As the microcapsules gradually disintegrate they provide a long-duration sustained release of buprenorphine. A tablet form of buprenorphine that is taken by holding it under the tongue is already used in the U.S. and around the world as an analgesic and as a treatment for opioid dependence; the tablet normally needs to be taken every day. The recent study was the first to test this new long-lasting depot formulation in humans. The study examined the safety and pharmacokinetics of the depot medication, and tested its effectiveness for reducing the opioid withdrawal syndrome and for reducing the effects of opioid challenge injections.
George E. Bigelow | EurekAlert!
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Physicists at the University of Bonn have managed to create optical hollows and more complex patterns into which the light of a Bose-Einstein condensate flows. The creation of such highly low-loss structures for light is a prerequisite for complex light circuits, such as for quantum information processing for a new generation of computers. The researchers are now presenting their results in the journal Nature Photonics.
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A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.
Since the beginning of the 20th century, superconductivity had been observed in some metals at temperatures only a few degrees above the absolute zero (minus...
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