Long-lasting depot medication appears safe and effective for treatment of narcotic addiction
A study in the January issue of the journal Drug and Alcohol Dependence reports that a long-lasting depot medication appears safe and effective for treatment of narcotic addiction. In the study a single injection prevented withdrawal discomfort for 6 weeks in heroin-dependent patients, reduced the effects of injected opiates, and provided a comfortable detoxification as it gradually wore off.
The study medication was an experimental injectable sustained-release depot formulation of the medication buprenorphine. The injection is a suspension of biodegradable microcapsules each containing small amounts of the buprenorphine medication. As the microcapsules gradually disintegrate they provide a long-duration sustained release of buprenorphine. A tablet form of buprenorphine that is taken by holding it under the tongue is already used in the U.S. and around the world as an analgesic and as a treatment for opioid dependence; the tablet normally needs to be taken every day. The recent study was the first to test this new long-lasting depot formulation in humans. The study examined the safety and pharmacokinetics of the depot medication, and tested its effectiveness for reducing the opioid withdrawal syndrome and for reducing the effects of opioid challenge injections.
George E. Bigelow | EurekAlert!
Amazingly flexible: Learning to read in your thirties profoundly transforms the brain
26.05.2017 | Max-Planck-Institut für Kognitions- und Neurowissenschaften
Fixating on faces
26.01.2017 | California Institute of Technology
Staphylococcus aureus is a feared pathogen (MRSA, multi-resistant S. aureus) due to frequent resistances against many antibiotics, especially in hospital infections. Researchers at the Paul-Ehrlich-Institut have identified immunological processes that prevent a successful immune response directed against the pathogenic agent. The delivery of bacterial proteins with RNA adjuvant or messenger RNA (mRNA) into immune cells allows the re-direction of the immune response towards an active defense against S. aureus. This could be of significant importance for the development of an effective vaccine. PLOS Pathogens has published these research results online on 25 May 2017.
Staphylococcus aureus (S. aureus) is a bacterium that colonizes by far more than half of the skin and the mucosa of adults, usually without causing infections....
Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.
The quantum computer has fuelled the imagination of scientists for decades: It is based on fundamentally different phenomena than a conventional computer....
An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.
We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...
Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.
Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...
An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...
24.05.2017 | Event News
23.05.2017 | Event News
22.05.2017 | Event News
26.05.2017 | Life Sciences
26.05.2017 | Life Sciences
26.05.2017 | Physics and Astronomy