Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Detection at a Distance for More Sensitive MRI

16.03.2004


In a recent experiment the letters CAL, carved through the end of a plastic tube placed in an MRI encoding coil, were reconstructed from 10 batches of spin-polarized xenon carried to a detection coil at a separate location. Although the batches arrived at different times, the spatial arrangement of the letters was accurately reproduced.


Song-I Han holds a probe incorporating separate encoding and detection coils, which will be placed in the high field of a superconducting magnet (background). A high-quality commercial encoding coil is located near a smaller detection coil, made in the laboratory and optimized for the highest detection sensitivity. Polarized xenon gas flows from the encoding coil to the detection coil.


Alexander Pines and his colleagues have discovered a remarkable new way to improve the versatility and sensitivity of magnetic resonance imaging (MRI) and the technology upon which it is based, nuclear magnetic resonance (NMR).

Pines, a pioneering NMR researcher, is Faculty Senior Scientist in the Materials Sciences Division at Lawrence Berkeley National Laboratory and Glenn T. Seaborg Professor of Chemistry at the University of California at Berkeley. The latest details of the new technique, known as remote detection, are reported by Pines, postdoctoral fellow Song-I Han, and doctoral candidate Juliette A. Seeley in the Journal of Magnetic Resonance.

Remote detection depends on physically separating the two basic steps of NMR, signal encoding and detection -- normally carried out in the same instrument -- in order to customize each step for the best results. Using laser-polarized xenon gas as the medium for "remembering" the encoded information and carrying it to the remote detection site, Pines and his group have achieved orders-of-magnitude improvement in MRI image resolution, plus manifold increases in NMR sensitivity.



"NMR encoding is exceptional at recovering chemical, biological, and physical information from samples, including living organisms, without disrupting them," says Pines, noting that MRI, a closely related technology, is equally adept at nondestructively picturing the insides of things. "The problem with this versatile technique is low sensitivity."

"However," says Han, "by separating the encoding and detection phases of NMR/MRI, we can gain data about physical, chemical, and biological properties of samples that we simply could not have gotten previously."

The conceptual foundation and feasibility of remote detection were earlier established in Pines’s laboratory by Adam Moulé, Megan Spence, Kimberly Pierce, and Sunil Saxena, in addition to Han and Seeley. The group reported their results in the August 5, 2003 issue of Proceedings of the National Academy of Sciences.

Saxena, now an assistant professor of chemistry at the University of Pittsburgh, remarks that while using two distinct pieces of apparatus "might seem counterintuitive at first glance, in many circumstances the use of one set-up in NMR leads to an uneasy balance between effective signal encoding and sensitive signal detection. By separating the two, not only can the signal fidelity be vastly improved, but also many new schemes that use much more powerful and sensitive detection and coding methods and principles can be envisaged."

The basic steps

NMR and MRI work because many atomic nuclei have magnetic moments, acting like toy bar magnets with north and south poles. In a magnetic field these spinning nuclei orient themselves along the field lines, with spins up or down. Slightly more energy is required to maintain the spin-down state.

In the encoding phase, a radiofrequency (RF) pulse matched to the energy difference between the two states knocks the target nuclei atilt, causing their spin axes to precess around the field lines like off-center toy gyroscopes. The exact precession rate is characteristic of each chemical species -- ubiquitous hydrogen is the most commonly used species in NMR and MRI -- and is also affected by the chemical and physical surroundings.

For MRI, an extra step encodes additional data. In addition to the uniform magnetic field, additional magnets are turned on briefly to superimpose fields that are stronger in one direction than the other. When the target nuclei are subjected to RF pulses, the differences in field strength are reflected in changed angles and speeds of precession. Together with the timing of the pulses, the gradient fields give each spinning nucleus a unique set of coordinates corresponding to its position.

During the detection phase, the net magnetic moment of the spinning nuclei is measured and analyzed for information about the chemical environment. In MRI the magnetization of each batch of spins formed by a train of radiofrequency pulses is measured, which yields the spatial characteristics of the sample.

Many factors affect the best ways to encode and detect information about a particular sample, whether it’s a living organism, a sample of tissue on a slide, a gas, liquid, or mineral sample, or even a solid surface.

During encoding, the RF coil has to be of the same dimension as the sample and often surrounds it; in addition, the main magnet has to be big enough to bathe the sample in a magnetic field that is typically very strong. In hospitals, for example, MRI equipment big enough to examine the head or lungs is bulky and expensive.

For both encoding and detection, the proportion of target nuclei in the sample is another important consideration. If the sample is large but the proportion of target nuclei is small, this small "filling factor" makes for a weak signal.

Polarization -- the difference in the number of spin-up versus spin-down nuclei -- is also vital. Even in a strong magnetic field, the excess of spin-up hydrogen is at best 1 in 100,000.

Xenon-129, unlike hydrogen, can be optically "hyperpolarized" before it is introduced into the sample, where its nuclei interact with the surroundings to encode NMR and MRI information. Because xenon is a noble gas, chemically inert and nontoxic, it is ideal for many biological applications. In hyperpolarized xenon some 20 percent of nuclei are spin-up, "so we don’t waste all those spins," Han remarks.

For optimum signal encoding, then, an NMR/MRI set-up may include a big RF coil and a strong magnetic field, while the best detection set-up for the same sample might require a more sensitive magnetic field and a smaller RF coil -- or even a supersensitive, non-MRI detector like a superconducting quantum interference device (SQUID) or a laser magnetometer.

Conversely, weak magnetic fields might be an advantage for encoding some subjects, for example patients with pacemakers or metal implants. Signals encoded in a weak field can only be recovered by a high-field detector.

"Remote detection allows us to combine the ability to obtain rich information about a variety of interesting samples with sensitive detection," Seeley says. "This is possible because nuclear spins have the ability to retain memory of their prior surroundings. They remember the information that was encoded in an environment not optimized for detection, and later they can be detected more sensitively."

Liberating NMR/MRI to do its best

Saxena describes the successful first attempt to prove the remote-detection principle: "We were able to demonstrate the rather fantastic notion that a picture of a sample cell could be obtained by saturating it with xenon gas in one spectrometer and then moving the gas -- by as much as 15 feet -- to another spectrometer for signal detection. Despite the long separation and travel time, the xenon gas faithfully remembered the shape of the sample cell."

Recently Seeley, Han, and Pines have demonstrated remote detection of MRI of porous samples at higher resolution, again using xenon gas to carry the signal to a detector of optimum design. The xenon is optically hyperpolarized, then introduced into the encoding chamber, where it flows through the voids in the sample. Because the sample is surrounded by a large radiofrequency coil, the filling factor is poor. Bearing the encoded information, the gas flows on to the detection chamber. Since xenon has a long spin-relaxation time, no spin-polarization or pulse-timing information is lost during transport.

In the recent experiment, the different encoding and detection coils were near each other but physically separated, and both were subjected to virtually the same strong magnetic field. With a much smaller detector coil the filling factor was greatly enhanced: the coil surrounds only the target nuclei, not the entire sample.

Encoding and detecting NMR/MRI signals separately makes many otherwise difficult or impossible applications possible. For example, xenon can be dissolved in chemical solutions or in the metabolic pathways of biological systems, then concentrated for more sensitive detection. Since xenon is not normally present in biological or geological samples, its signal stands out clearly against a noiseless background.

Other signal carriers can also be used for remote detection, including hyperpolarized helium gas for medical imaging or liquid oil or water for geological analysis. Since only the carrier reaches the detector, alternate detection methods, incompatible with the sample because they may be intrusive or require transparency, can also be used -- for example, optical methods that can detect the miniscule NMR signals from living cells.

By freeing the detection phase from the confines of the sample chamber, remote detection liberates NMR/MRI technology from its restraints and opens a new realm of possibilities -- from targets as big as geological core samples and human bodies down to microstructures and single cells. No other spectroscopic or imaging tool has such a rich combination of capabilities.

The Berkeley Lab is a U.S. Department of Energy national laboratory located in Berkeley, California. It conducts unclassified scientific research and is managed by the University of California

Paul Preuss | LBNL
Further information:
http://www.lbl.gov/Science-Articles/Archive/MSD-remote-detection-MRI.html

More articles from Process Engineering:

nachricht Quick, Precise, but not Cold
17.05.2017 | Fraunhofer-Institut für Lasertechnik ILT

nachricht A laser for divers
03.05.2017 | Laser Zentrum Hannover e.V.

All articles from Process Engineering >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Exotic quantum states made from light: Physicists create optical “wells” for a super-photon

Physicists at the University of Bonn have managed to create optical hollows and more complex patterns into which the light of a Bose-Einstein condensate flows. The creation of such highly low-loss structures for light is a prerequisite for complex light circuits, such as for quantum information processing for a new generation of computers. The researchers are now presenting their results in the journal Nature Photonics.

Light particles (photons) occur as tiny, indivisible portions. Many thousands of these light portions can be merged to form a single super-photon if they are...

Im Focus: Circular RNA linked to brain function

For the first time, scientists have shown that circular RNA is linked to brain function. When a RNA molecule called Cdr1as was deleted from the genome of mice, the animals had problems filtering out unnecessary information – like patients suffering from neuropsychiatric disorders.

While hundreds of circular RNAs (circRNAs) are abundant in mammalian brains, one big question has remained unanswered: What are they actually good for? In the...

Im Focus: RAVAN CubeSat measures Earth's outgoing energy

An experimental small satellite has successfully collected and delivered data on a key measurement for predicting changes in Earth's climate.

The Radiometer Assessment using Vertically Aligned Nanotubes (RAVAN) CubeSat was launched into low-Earth orbit on Nov. 11, 2016, in order to test new...

Im Focus: Scientists shine new light on the “other high temperature superconductor”

A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.

Since the beginning of the 20th century, superconductivity had been observed in some metals at temperatures only a few degrees above the absolute zero (minus...

Im Focus: Scientists improve forecast of increasing hazard on Ecuadorian volcano

Researchers from the University of Miami (UM) Rosenstiel School of Marine and Atmospheric Science, the Italian Space Agency (ASI), and the Instituto Geofisico--Escuela Politecnica Nacional (IGEPN) of Ecuador, showed an increasing volcanic danger on Cotopaxi in Ecuador using a powerful technique known as Interferometric Synthetic Aperture Radar (InSAR).

The Andes region in which Cotopaxi volcano is located is known to contain some of the world's most serious volcanic hazard. A mid- to large-size eruption has...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Call for Papers – ICNFT 2018, 5th International Conference on New Forming Technology

16.08.2017 | Event News

Sustainability is the business model of tomorrow

04.08.2017 | Event News

Clash of Realities 2017: Registration now open. International Conference at TH Köln

26.07.2017 | Event News

 
Latest News

New thruster design increases efficiency for future spaceflight

16.08.2017 | Physics and Astronomy

Transporting spin: A graphene and boron nitride heterostructure creates large spin signals

16.08.2017 | Materials Sciences

A new method for the 3-D printing of living tissues

16.08.2017 | Interdisciplinary Research

VideoLinks
B2B-VideoLinks
More VideoLinks >>>