Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Selective nanofilters for proteins, DNA

03.07.2002


A new type of nanotechnology-based filter that can separate out mixtures of biological molecules has been developed by researchers at the University of California, Davis. The technology could potentially be used, for example, to build small-scale devices for research in genomics by sorting mixtures of different proteins or DNA molecules.



The filter consists of a polycarbonate membrane etched with tiny, evenly-sized pores less than 10 nanometers -- a few billionths of an inch -- in size. The pores are lined with a thin layer of gold and then with another layer of oily molecules called thiols. The thiols spontaneously arrange themselves into a membrane one molecule deep, with all the thiol molecules pointing the same way.

These thiols are chains of carbon atoms, with a sulfur atom at one end and an acidic region at the other end. The sulfur allows the thiol to stick to the gold layer, and the acidic end can then interact with whatever flows past. The final pores are less than nine nanometers wide.


UC Davis researchers Kyoung-Yong Chun and Pieter Stroeve found that by changing the pH on either side of the membrane, they could "open" or "close" the pores to different proteins even of similar size, using a method called electrostatic screening. Existing filters can only effectively separate proteins or biological molecules of different sizes.

"The switchable technology will be important for transport on the nano-scale, particularly for nano and micro-sensing, analysis on a chip and micro-fluidic devices," Stroeve said. Another application could be in controlled drug release, supplying drugs over a period of time when the body needs it, he said.

The work is published in the June 11 issue of the journal Langmuir.

Media contacts: Pieter Stroeve, Chemical Engineering and Materials Science, 530-752-8778, pstroeve@ucdavis.edu; Andy Fell, News Service, 530-752-4533, ahfell@ucdavis.edu.

Andy Fell | EurekAlert!

More articles from Process Engineering:

nachricht Dresdner scientists print tomorrow’s world
08.02.2017 | Fraunhofer-Institut für Werkstoff- und Strahltechnik IWS

nachricht New technology for mass-production of complex molded composite components
23.01.2017 | Evonik Industries AG

All articles from Process Engineering >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Breakthrough with a chain of gold atoms

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

Im Focus: DNA repair: a new letter in the cell alphabet

Results reveal how discoveries may be hidden in scientific “blind spots”

Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...

Im Focus: Dresdner scientists print tomorrow’s world

The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.

The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...

Im Focus: Mimicking nature's cellular architectures via 3-D printing

Research offers new level of control over the structure of 3-D printed materials

Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...

Im Focus: Three Magnetic States for Each Hole

Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".

Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Booth and panel discussion – The Lindau Nobel Laureate Meetings at the AAAS 2017 Annual Meeting

13.02.2017 | Event News

Complex Loading versus Hidden Reserves

10.02.2017 | Event News

International Conference on Crystal Growth in Freiburg

09.02.2017 | Event News

 
Latest News

Stingless bees have their nests protected by soldiers

24.02.2017 | Life Sciences

New risk factors for anxiety disorders

24.02.2017 | Life Sciences

MWC 2017: 5G Capital Berlin

24.02.2017 | Trade Fair News

VideoLinks
B2B-VideoLinks
More VideoLinks >>>