"The electronics needs in medical imaging look very closely related to the needs we have in high-energy physics," said Henry Frisch, Professor in Physics at the University of Chicago. "Physics tends to advance by new capabilities in measurement, the same in radiology."
Radiologists, medical physicists and high-energy physicists share a desire to more precisely measure the velocity and location of subatomic particles, Frisch explained. A significant improvement in Positron Emission Tomography technology could mean the difference between life and death for some patients, said Chin-Tu Chen, Associate Professor in Radiology at the University of Chicago. Being able to detect a tumor measuring a quarter of an inch in diameter rather than half an inch would mean initiating treatment when the disease mass is eight times smaller by volume.
Frisch, Chen and physicist Karen Byrum of Argonne National Laboratory are pursuing the joint effort with initial funding provided by the U.S. Department of Energy, Argonne and the University of Chicago Cancer Research Center. Their work is part of an international scientific trend to apply high-energy physics technology to biomedical imaging techniques.
While medical physicists look for disease, high-energy physicists seek to identify what types of subatomic particles they produce in collider experiments. The identity of many such particles remains a mystery, and thus a barrier to some potentially dramatic new insights into the operation of the universe at the smallest of scales.
Today's high-energy physics experiments typically measure particle velocities to within an accuracy of 100 picoseconds (a trillionth of a second). A photon of light can travel approximately one inch in 100 picoseconds. Frisch would like to increase the resolution to one picosecond.
"We are not as ambitious as Henry," Chen said. "We are aiming more toward 30 picoseconds."
In the PET world, more accurate particle velocity measurements would translate into improved image quality and thus more accurate diagnoses, Chen said. Doing so would require an emerging technique called "time-of-flight PET," which provides a positional measurement that conventional PET technology lacks.
Only last December did the first commercial time-of-flight PET scanners become available. These scanners provide a time-of-flight resolution of 750 picoseconds, which corresponds to a resolution of a couple inches. "That's really not useful for improving the spatial resolution of PET," said Chien-Min Kao, Assistant Professor in Radiology.
But when used in connection with conventional PET, time-of-flight measurements do help improve image quality by sorting out useful signals from confusing static, Kao said. Physicists can help here, because they have solved some data-acquisition problems that still plague biomedical imaging.
In conventional PET scans, patients receive a dose of short-lived radioactive material that emits positrons. The PET scanner then detects the photons released when the positrons collide with neighboring electrons. This approach generates millions of signals, including countless spurious signals that require intense computational analysis to filter out. Furthermore, the locations of the signals can only be determined along the direction of the detector face.
But collection of new time-of-flight data permits determination of signal locations in a direction at a right angle to the detector face as well. "If time-of-flight measurements can be assessed with an accuracy less than 30 picoseconds, better resolution in both directions can be achieved, essentially eliminating the need for complex and costly image reconstruction," Chen said.
The medical imaging community first showed interest in time-of-flight PET in the early 1980s. Chen, then a Ph.D. student, devoted his dissertation to the topic. But the limited precision available from the detector crystals of the day prevented the concept from moving beyond the prototype stage. "I shelved my dissertation after I graduated, and for 15 years or so, no one talked about time-of-flight PET," he said.
In recent years, the development of faster crystals has renewed biomedical interest in the technique, as Frisch learned when he and Argonne's Karen Byrum organized a November 2005 workshop of picosecond particle measurements. The workshop brought them together with Chen and Patrick Le Dû of the French atomic energy commission.
Le Dû and Frisch had worked together almost 20 years ago to develop an instrument for the ill-fated Superconducting Supercollider. Nevertheless, "It was a complete surprise to find out that we were thinking along absolutely parallel lines," Frisch said of the ideas that Le Dû presented in his talk.
Scientists all over Europe, in fact, now work in concert to develop time-of-flight PET technology. Frisch, Chen, Kao and Byrum, meanwhile, have formed their own biomedical imaging effort that includes the Electronics Design Group at the University of Chicago's Enrico Fermi Institute.
Frisch recalled what happened when he first shared his idea for improving subatomic particle measurements with Harold Sanders, who heads the Electronics Group. "That was on a Friday afternoon, and Harold said, 'you're out of your mind.'" But the following Monday, Sanders said, "You know, maybe it's not completely crazy."
That was before they began working with Chen more than a year ago. "It still looks good, and we think it's far from crazy," Frisch said. "In fact, it may be possible."
Steve Koppes | EurekAlert!
Igniting a solar flare in the corona with lower-atmosphere kindling
29.03.2017 | New Jersey Institute of Technology
NASA spacecraft investigate clues in radiation belts
28.03.2017 | NASA/Goddard Space Flight Center
The Institute of Semiconductor Technology and the Institute of Physical and Theoretical Chemistry, both members of the Laboratory for Emerging Nanometrology (LENA), at Technische Universität Braunschweig are partners in a new European research project entitled ChipScope, which aims to develop a completely new and extremely small optical microscope capable of observing the interior of living cells in real time. A consortium of 7 partners from 5 countries will tackle this issue with very ambitious objectives during a four-year research program.
To demonstrate the usefulness of this new scientific tool, at the end of the project the developed chip-sized microscope will be used to observe in real-time...
Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.
The results will be published on March 22 in the journal „Astronomy & Astrophysics“.
Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...
Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.
Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...
In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...
20.03.2017 | Event News
14.03.2017 | Event News
07.03.2017 | Event News
29.03.2017 | Materials Sciences
29.03.2017 | Physics and Astronomy
29.03.2017 | Earth Sciences