NIST physical scientist Joy Dunkers positions a polymer scaffold sample for imaging.
In the November issue of Optics Express*, National Institute of Standards and Technology (NIST) scientists describe a novel combination of microscopes that can peer deep into tissue-engineering scaffolds and monitor the growth and differentiation of cells ultimately intended to develop into implantable organs or other body-part replacements.
The new dual-imaging tool provides a much needed capability for the emerging tissue engineering field, which aims to regenerate form and function in damaged or diseased tissues and organs. Until now, scrutiny of this complicated, three-dimensional process has been limited to the top-most layers of the scaffolds used to coax and sustain cell development.
Composed of biodegradable polymers or other building materials, scaffolds are seeded with cells that grow, multiply, and assemble into three-dimensional tissues. Whether the cells respond and organize as intended in this synthetic environment depends greatly on the composition, properties, and architecture of the scaffolds’ porous interiors. Tools for simultaneously monitoring microstructure and cellular activity can help scientists to tease apart the essentials of this interactive relationship. In turn, such knowledge can speed development of tissue-engineered products ranging from skin replacements to substitute livers to inside-the-body treatments of osteoporosis.
Hope to discover sure signs of life on Mars? New research says look for the element vanadium
22.09.2017 | University of Kansas
22.09.2017 | Forschungszentrum MATHEON ECMath
Plants and algae use the enzyme Rubisco to fix carbon dioxide, removing it from the atmosphere and converting it into biomass. Algae have figured out a way to increase the efficiency of carbon fixation. They gather most of their Rubisco into a ball-shaped microcompartment called the pyrenoid, which they flood with a high local concentration of carbon dioxide. A team of scientists at Princeton University, the Carnegie Institution for Science, Stanford University and the Max Plank Institute of Biochemistry have unravelled the mysteries of how the pyrenoid is assembled. These insights can help to engineer crops that remove more carbon dioxide from the atmosphere while producing more food.
A warming planet
Our brains house extremely complex neuronal circuits, whose detailed structures are still largely unknown. This is especially true for the so-called cerebral cortex of mammals, where among other things vision, thoughts or spatial orientation are being computed. Here the rules by which nerve cells are connected to each other are only partly understood. A team of scientists around Moritz Helmstaedter at the Frankfiurt Max Planck Institute for Brain Research and Helene Schmidt (Humboldt University in Berlin) have now discovered a surprisingly precise nerve cell connectivity pattern in the part of the cerebral cortex that is responsible for orienting the individual animal or human in space.
The researchers report online in Nature (Schmidt et al., 2017. Axonal synapse sorting in medial entorhinal cortex, DOI: 10.1038/nature24005) that synapses in...
Whispering gallery mode (WGM) resonators are used to make tiny micro-lasers, sensors, switches, routers and other devices. These tiny structures rely on a...
Using ultrafast flashes of laser and x-ray radiation, scientists at the Max Planck Institute of Quantum Optics (Garching, Germany) took snapshots of the briefest electron motion inside a solid material to date. The electron motion lasted only 750 billionths of the billionth of a second before it fainted, setting a new record of human capability to capture ultrafast processes inside solids!
When x-rays shine onto solid materials or large molecules, an electron is pushed away from its original place near the nucleus of the atom, leaving a hole...
For the first time, physicists have successfully imaged spiral magnetic ordering in a multiferroic material. These materials are considered highly promising candidates for future data storage media. The researchers were able to prove their findings using unique quantum sensors that were developed at Basel University and that can analyze electromagnetic fields on the nanometer scale. The results – obtained by scientists from the University of Basel’s Department of Physics, the Swiss Nanoscience Institute, the University of Montpellier and several laboratories from University Paris-Saclay – were recently published in the journal Nature.
Multiferroics are materials that simultaneously react to electric and magnetic fields. These two properties are rarely found together, and their combined...
19.09.2017 | Event News
12.09.2017 | Event News
06.09.2017 | Event News
22.09.2017 | Life Sciences
22.09.2017 | Medical Engineering
22.09.2017 | Physics and Astronomy