Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New optical tweezers trap specimens just a few nanometers across

05.12.2012
A microscale technique known as optical trapping uses beams of light as tweezers to hold and manipulate tiny particles. Stanford researchers have found a new way to trap particles smaller than 10 nanometers - and potentially down to just a few atoms in size – which until now have escaped light’s grasp.
To grasp and move microscopic objects, such as bacteria and the components of living cells, scientists can harness the power of concentrated light to manipulate them without ever physically touching them.

Now, doctoral student Amr Saleh and Assistant Professor Jennifer Dionne, researchers at the Stanford School of Engineering, have designed an innovative light aperture that allows them to optically trap smaller objects than ever before – potentially just a few atoms in size.

The process of optical trapping – or optical tweezing, as it is often known – involves sculpting a beam of light into a narrow point that produces a strong electromagnetic field. The beam attracts tiny objects and traps them in place, just like a pair of tweezers.
Unfortunately, there are natural limits to the technique. The process breaks down for objects significantly smaller than the wavelength of light. Therefore, optical tweezers cannot grasp super-small objects like individual proteins, which are only a couple of nanometers in diameter.

Saleh and Dionne have shown theoretically that light passed through their novel aperture would stably trap objects as small as 2 nanometers. The design was published in the journal Nano Letters, and Saleh is now building a working prototype of the microscopic device.

Agonies of scale

As a materials scientist, Jennifer Dionne imagined an optical tool that would help her precisely move molecular building blocks into new configurations. “Optical tweezers seemed like a really cool way of assembling new materials,” she said. Dionne is the paper’s senior author.

Unfortunately, existing optical tweezers are not adept at handling these tiny building blocks. “It’s been a known for several decades that trapping nano-sized objects with light would be challenging,” said Dionne.

The problem is inherent to the light beam itself. Optical trapping typically uses light in the visible spectrum (with wavelengths between 400 and 700 nanometers) so that scientist can actually see the specimen as they manipulate it.

Due to a physical constraint called the diffraction limit of light, the smallest space in which optical tweezing can trap a particle is approximately half the wavelength of the light beam. In the visible spectrum this would be about 200 nanometers – half the shortest visible wavelength of 400 nanometers.

Thus, if the specimen in question is only 2 nanometers wide – the size of a typical protein – trapping it in a space of 200 nanometers allows only very loose control at best. Scale-wise, it is akin to guiding a minnow with 20-meter-wide fishing net.

Additionally, the optical force that light can exert on an object diminishes as the objects get smaller. “If you want to trap something very small, you need a tremendous amount of power, which will burn your specimen before you can trap it,” Saleh said.

Some researchers get around this problem by attaching the specimen to a much larger object that can be dragged around with light. Dionne noted, however, that important molecules like insulin or glucose might behave quite differently when attached to giant anchors than they would on their own. To isolate and move a tiny object without frying it, the researchers needed a way around the limitations of conventional optical trapping.

The promise of plasmonics

Dionne says that the most promising method of moving tiny particles with light relies on plasmonics, a technology that takes advantage of the optical and electronic properties of metals. A strong conductor like silver or gold holds its electrons weakly, giving them freedom to move around near the metal’s surface.

When light waves interact with these mobile electrons, they move in what Dionne describes as “a very well-defined, intricate dance,” scattering and sculpting the light into electromagnetic waves called plasmon-polaritons. These oscillations have a very short wavelength compared to visible light, enabling them to trap small specimens more tightly.

Dionne and Saleh applied plasmonic principles to design a new aperture that focuses light more effectively. The aperture is structured much like the coaxial cables that transmit television signals, Saleh said. A nanoscale tube of silver is coated in a thin layer of silicon dioxide, and those two layers are wrapped in a second outer layer of silver. When light shines through the silicon dioxide ring, it creates plasmons at the interface where the silver and silicon dioxide meet. The plasmons travel along aperture and emerge on the other end as a powerful, concentrated beam of light.

The Stanford device is not the first plasmonic trap, but it promises to trap the smallest specimens recorded to date. Saleh and Dionne have theoretically shown that their design can trap particles as small as 2 nanometers. With further improvements, their design could even be used to optically trap molecules even smaller.

An optical multi-tool

As nanoscale tools go, this new optical trap would be quite a versatile gadget. While the researchers first envisioned it in the context of materials science, its potential applications span many other fields including biology, pharmacology, and genomics.

Dionne said she would first like to trap a single protein, and try to unravel its twisted structure using visible light alone. Dionne points out that the beam of light could also be used to exert a strong pulling force on stem cells, which has been shown to change how the these important building blocks differentiate into various kinds of cells. Saleh, on the other hand, is particularly excited about moving and stacking tiny particles to explore their attractive forces and create new, “bottom-up” materials and devices.

All this is down the road, however. In the meantime, Saleh is working on turning the design into reality. He hopes to have a prototype by early 2013.

Funding for this research was provided by a Stanford Terman fellowship, an AFOSR Young Investigator Grant and a NSF Career Award.

Kelly Servick is a science-writing intern for the Stanford University School of Engineering.

Andrew Myers | EurekAlert!
Further information:
http://www.stanford.edu
http://engineering.stanford.edu/press/new-optical-tweezers-trap-specimens-just-few-nanometers-across

More articles from Physics and Astronomy:

nachricht From Hannover around the world and to the Mars: LZH delivers laser for ExoMars 2020
21.11.2017 | Laser Zentrum Hannover e.V.

nachricht Taking a spin on plasma space tornadoes with NASA observations
20.11.2017 | NASA/Goddard Space Flight Center

All articles from Physics and Astronomy >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: A “cosmic snake” reveals the structure of remote galaxies

The formation of stars in distant galaxies is still largely unexplored. For the first time, astron-omers at the University of Geneva have now been able to closely observe a star system six billion light-years away. In doing so, they are confirming earlier simulations made by the University of Zurich. One special effect is made possible by the multiple reflections of images that run through the cosmos like a snake.

Today, astronomers have a pretty accurate idea of how stars were formed in the recent cosmic past. But do these laws also apply to older galaxies? For around a...

Im Focus: Visual intelligence is not the same as IQ

Just because someone is smart and well-motivated doesn't mean he or she can learn the visual skills needed to excel at tasks like matching fingerprints, interpreting medical X-rays, keeping track of aircraft on radar displays or forensic face matching.

That is the implication of a new study which shows for the first time that there is a broad range of differences in people's visual ability and that these...

Im Focus: Novel Nano-CT device creates high-resolution 3D-X-rays of tiny velvet worm legs

Computer Tomography (CT) is a standard procedure in hospitals, but so far, the technology has not been suitable for imaging extremely small objects. In PNAS, a team from the Technical University of Munich (TUM) describes a Nano-CT device that creates three-dimensional x-ray images at resolutions up to 100 nanometers. The first test application: Together with colleagues from the University of Kassel and Helmholtz-Zentrum Geesthacht the researchers analyzed the locomotory system of a velvet worm.

During a CT analysis, the object under investigation is x-rayed and a detector measures the respective amount of radiation absorbed from various angles....

Im Focus: Researchers Develop Data Bus for Quantum Computer

The quantum world is fragile; error correction codes are needed to protect the information stored in a quantum object from the deteriorating effects of noise. Quantum physicists in Innsbruck have developed a protocol to pass quantum information between differently encoded building blocks of a future quantum computer, such as processors and memories. Scientists may use this protocol in the future to build a data bus for quantum computers. The researchers have published their work in the journal Nature Communications.

Future quantum computers will be able to solve problems where conventional computers fail today. We are still far away from any large-scale implementation,...

Im Focus: Wrinkles give heat a jolt in pillared graphene

Rice University researchers test 3-D carbon nanostructures' thermal transport abilities

Pillared graphene would transfer heat better if the theoretical material had a few asymmetric junctions that caused wrinkles, according to Rice University...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Ecology Across Borders: International conference brings together 1,500 ecologists

15.11.2017 | Event News

Road into laboratory: Users discuss biaxial fatigue-testing for car and truck wheel

15.11.2017 | Event News

#Berlin5GWeek: The right network for Industry 4.0

30.10.2017 | Event News

 
Latest News

Antarctic landscape insights keep ice loss forecasts on the radar

20.11.2017 | Earth Sciences

Filling the gap: High-latitude volcanic eruptions also have global impact

20.11.2017 | Earth Sciences

Water world

20.11.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>