Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

NYU Physicists Devise Method for Building Artificial Tissue

29.05.2012
New York University physicists have developed a method that models biological cell-to-cell adhesion that could also have industrial applications.

This system, created in the laboratory of Jasna Brujiæ, an assistant professor in NYU’s Department of Physics and part of its Center for Soft Matter Research, is an oil-in-water solution whose surface properties reproduce those found on biological cells.

Specifically, adhesion between compressed oil droplets mimics the mechanical properties of tissues and opens the path to numerous practical applications, ranging from biocompatible cosmetics to artificial tissue engineering.

Their method is described in the journal the Proceedings of the National Academy of Sciences.

Previously, Brujiæ’s laboratory has determined how spheres pack and devised methods for manipulating the packing process. In this PNAS study, Brujiæ and her research team sought to create a method that would address the role of packing in tissues from the point of view of how mechanical forces affect protein-protein adhesion between cells.

In biology, cell-to-cell adhesion is crucial to the integrity of tissue structure—cells must come together and stick in order to ensure tissue cohesion. However, the daunting complexity of biological systems has long prevented their description using general theoretical concepts taken from the physical sciences. For this reason, the research team designed an original biomimetic solution, or emulsion, that reproduces the main features of cell-to-cell adhesion in tissues.

Emulsions form the basis for a range of consumer products, including butter, ice cream, and milk. In addition, the emulsion in the PNAS study is tuned to match the attractive and repulsive interactions that govern adhesion between cells. The experimental conditions reveal the circumstances under which pushing forces are necessary to create adhesion.

By varying the amount of force by which the droplets of oil were compressed by centrifugation and the amount of salt added to this solution, the NYU team was able to isolate the optimal conditions for cell-to-cell adhesion. Screening electrostatic charges by the addition of salt and compressing the droplets by force enhances protein-protein interactions on the droplet surfaces. This leads to adhesion between contacting droplets covering all the interfaces, just as in the case of biological tissues.

Their results, which matched the researchers’ theoretical modeling of the process, offer a method for manipulating force and pressure in order to bind emulsions. This serves as a starting point for enriching a range of consumer products, by reconfiguring their molecular make-up to enhance consistency and function, and for improving pharmaceuticals, by bolstering the delivery of therapeutic molecules to the blood stream.

The study’s other authors were Lea-Laetitia Pontani, a postdoctoral research scientist, and Ivane Jorjadze, a graduate student, both from NYU’s Department of Physics and the Center for Soft Matter Research, as well as Virgile Viasnoff, an Associate Professor at the National University of Singapore and the French research institute, CNRS/ESPCI.

For more on the Brujiæ Laboratory, go to http://www.physics.nyu.edu/~jb2929/index.html; for more on the Center for Soft Matter Research, go to http://csmr.as.nyu.edu/page/home.

The research was performed in the NYU Materials Research Science and Engineering Center (MRSEC), which is supported by the National Science Foundation.

James Devitt | Newswise Science News
Further information:
http://www.nyu.edu

More articles from Physics and Astronomy:

nachricht Long-lived storage of a photonic qubit for worldwide teleportation
12.12.2017 | Max-Planck-Institut für Quantenoptik

nachricht Telescopes team up to study giant galaxy
12.12.2017 | International Centre for Radio Astronomy Research

All articles from Physics and Astronomy >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Long-lived storage of a photonic qubit for worldwide teleportation

MPQ scientists achieve long storage times for photonic quantum bits which break the lower bound for direct teleportation in a global quantum network.

Concerning the development of quantum memories for the realization of global quantum networks, scientists of the Quantum Dynamics Division led by Professor...

Im Focus: Electromagnetic water cloak eliminates drag and wake

Detailed calculations show water cloaks are feasible with today's technology

Researchers have developed a water cloaking concept based on electromagnetic forces that could eliminate an object's wake, greatly reducing its drag while...

Im Focus: Scientists channel graphene to understand filtration and ion transport into cells

Tiny pores at a cell's entryway act as miniature bouncers, letting in some electrically charged atoms--ions--but blocking others. Operating as exquisitely sensitive filters, these "ion channels" play a critical role in biological functions such as muscle contraction and the firing of brain cells.

To rapidly transport the right ions through the cell membrane, the tiny channels rely on a complex interplay between the ions and surrounding molecules,...

Im Focus: Towards data storage at the single molecule level

The miniaturization of the current technology of storage media is hindered by fundamental limits of quantum mechanics. A new approach consists in using so-called spin-crossover molecules as the smallest possible storage unit. Similar to normal hard drives, these special molecules can save information via their magnetic state. A research team from Kiel University has now managed to successfully place a new class of spin-crossover molecules onto a surface and to improve the molecule’s storage capacity. The storage density of conventional hard drives could therefore theoretically be increased by more than one hundred fold. The study has been published in the scientific journal Nano Letters.

Over the past few years, the building blocks of storage media have gotten ever smaller. But further miniaturization of the current technology is hindered by...

Im Focus: Successful Mechanical Testing of Nanowires

With innovative experiments, researchers at the Helmholtz-Zentrums Geesthacht and the Technical University Hamburg unravel why tiny metallic structures are extremely strong

Light-weight and simultaneously strong – porous metallic nanomaterials promise interesting applications as, for instance, for future aeroplanes with enhanced...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

See, understand and experience the work of the future

11.12.2017 | Event News

Innovative strategies to tackle parasitic worms

08.12.2017 | Event News

AKL’18: The opportunities and challenges of digitalization in the laser industry

07.12.2017 | Event News

 
Latest News

Long-lived storage of a photonic qubit for worldwide teleportation

12.12.2017 | Physics and Astronomy

Multi-year submarine-canyon study challenges textbook theories about turbidity currents

12.12.2017 | Earth Sciences

Electromagnetic water cloak eliminates drag and wake

12.12.2017 | Power and Electrical Engineering

VideoLinks
B2B-VideoLinks
More VideoLinks >>>