Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Microfluidic integrated circuit could help enable home diagnostic tests

23.04.2010
As a way to simplify lab-on-a-chip devices that could offer quicker, cheaper and more portable medical tests, University of Michigan researchers have created microfluidic integrated circuits.

Just as electronic circuits intelligently route the flow of electricity on computer chips without external controls, these microfluidic circuits regulate the flow of fluid through their devices without instructions from outside systems.

A paper on the technology is newly published online in Nature Physics.

A microfluidic device, or lab-on-a-chip, integrates multiple laboratory functions onto one chip just centimeters in size. The devices allow researchers to experiment on tiny sample sizes, and also to simultaneously perform multiple experiments on the same material. They can be engineered to mimic the human body more closely than the Petri dish does. They could lead to instant home tests for illnesses, food contaminants and toxic gases, among other advances.

“In most microfluidic devices today, there are essentially little fingers or pressure forces that open and close each individual valve to route fluid through the device during experiments. That is, there is an extra layer of control machinery that is required to manipulate the current in the fluidic circuit,” said Shu Takayama, the principal investigator on the project. Takayama is an associate professor in the U-M Department of Biomedical Engineering.

That’s similar to how electronic circuits were manipulated a century ago. Then, with the development of the integrated circuit, the “thinking” became embedded in the chip itself—a technological breakthrough that enabled personal computers, Takayama said.

“We have literally made a microfluidic integrated circuit,” said Bobak Mosadegh, a doctoral student in Takayama’s lab who is first author of the paper.

The external controls that power today’s microfluidic devices can be cumbersome. Each valve on a chip (and there could be dozens of them) requires its own electromechanical push from an off-chip actuator or pump. This has made it difficult to shrink microfluidic systems to palm- or fingertip-sized diagnostic devices.

The Takayama lab’s innovation is a step in this direction. His research group has devised a strategy to produce the fluidic counterparts of key electrical components including transistors, diodes, resistors and capacitors, and to efficiently network these components to automatically regulate fluid flow within the device.

These components are made using conventional techniques, so they are compatible with all other microfluidic components such as mixers, filters and cell culture chambers, the researchers say.

“We’ve made a versatile control system,” Mosadegh said. “We envision that this technology will become a platform for researchers and companies in the microfluidics field to develop sophisticated self-controlled microfluidic devices that automatically process biofluids such as blood and pharmaceuticals for diagnostics or other applications.

“Just as the integrated circuit brought the digital information processing power of computers to the people, we envision our microfluidic analog will be able to do the same for cellular and biochemical information.”

The paper is titled “Integrated Elastomeric Components for Autonomous Regulation of Sequential and Oscillatory Flow Switching in Microfluidic Devices.” This research is funded by the National Institutes of Health, the U.S. Department of Education and the National Institute for Dental and Craniofacial Research. Also contributing were researchers from the U-M departments of Biomedical Engineering and Mechanical Engineering as well as the Macromolecular Science and Engineering Center.

The university is pursuing patent protection for the intellectual property, and is seeking commercialization partners to help bring the technology to market.

Michigan Engineering:
The University of Michigan College of Engineering is ranked among the top engineering schools in the country. At $160 million annually, its engineering research budget is one of largest of any public university. Michigan Engineering is home to 11 academic departments and a National Science Foundation Engineering Research Center. The college plays a leading role in the Michigan Memorial Phoenix Energy Institute and hosts the world class Lurie Nanofabrication Facility. Michigan Engineering's premier scholarship, international scale and multidisciplinary scope combine to create The Michigan Difference. Find out more at http://www.engin.umich.edu/.

Nicole Casal Moore | EurekAlert!
Further information:
http://www.engin.umich.edu

More articles from Physics and Astronomy:

nachricht Astronomers release most complete ultraviolet-light survey of nearby galaxies
18.05.2018 | NASA/Goddard Space Flight Center

nachricht A quantum entanglement between two physically separated ultra-cold atomic clouds
17.05.2018 | University of the Basque Country

All articles from Physics and Astronomy >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Explanation for puzzling quantum oscillations has been found

So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics

Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...

Im Focus: Dozens of binaries from Milky Way's globular clusters could be detectable by LISA

Next-generation gravitational wave detector in space will complement LIGO on Earth

The historic first detection of gravitational waves from colliding black holes far outside our galaxy opened a new window to understanding the universe. A...

Im Focus: Entangled atoms shine in unison

A team led by Austrian experimental physicist Rainer Blatt has succeeded in characterizing the quantum entanglement of two spatially separated atoms by observing their light emission. This fundamental demonstration could lead to the development of highly sensitive optical gradiometers for the precise measurement of the gravitational field or the earth's magnetic field.

The age of quantum technology has long been heralded. Decades of research into the quantum world have led to the development of methods that make it possible...

Im Focus: Computer-Designed Customized Regenerative Heart Valves

Cardiovascular tissue engineering aims to treat heart disease with prostheses that grow and regenerate. Now, researchers from the University of Zurich, the Technical University Eindhoven and the Charité Berlin have successfully implanted regenerative heart valves, designed with the aid of computer simulations, into sheep for the first time.

Producing living tissue or organs based on human cells is one of the main research fields in regenerative medicine. Tissue engineering, which involves growing...

Im Focus: Light-induced superconductivity under high pressure

A team of scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg investigated optically-induced superconductivity in the alkali-doped fulleride K3C60under high external pressures. This study allowed, on one hand, to uniquely assess the nature of the transient state as a superconducting phase. In addition, it unveiled the possibility to induce superconductivity in K3C60 at temperatures far above the -170 degrees Celsius hypothesized previously, and rather all the way to room temperature. The paper by Cantaluppi et al has been published in Nature Physics.

Unlike ordinary metals, superconductors have the unique capability of transporting electrical currents without any loss. Nowadays, their technological...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Save the date: Forum European Neuroscience – 07-11 July 2018 in Berlin, Germany

02.05.2018 | Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

Unique scope of UV LED technologies and applications presented in Berlin: ICULTA-2018

12.04.2018 | Event News

 
Latest News

Supersonic waves may help electronics beat the heat

18.05.2018 | Power and Electrical Engineering

Keeping a Close Eye on Ice Loss

18.05.2018 | Information Technology

CrowdWater: An App for Flood Research

18.05.2018 | Information Technology

VideoLinks
Science & Research
Overview of more VideoLinks >>>