Just as electronic circuits intelligently route the flow of electricity on computer chips without external controls, these microfluidic circuits regulate the flow of fluid through their devices without instructions from outside systems.
A paper on the technology is newly published online in Nature Physics.
A microfluidic device, or lab-on-a-chip, integrates multiple laboratory functions onto one chip just centimeters in size. The devices allow researchers to experiment on tiny sample sizes, and also to simultaneously perform multiple experiments on the same material. They can be engineered to mimic the human body more closely than the Petri dish does. They could lead to instant home tests for illnesses, food contaminants and toxic gases, among other advances.
“In most microfluidic devices today, there are essentially little fingers or pressure forces that open and close each individual valve to route fluid through the device during experiments. That is, there is an extra layer of control machinery that is required to manipulate the current in the fluidic circuit,” said Shu Takayama, the principal investigator on the project. Takayama is an associate professor in the U-M Department of Biomedical Engineering.
That’s similar to how electronic circuits were manipulated a century ago. Then, with the development of the integrated circuit, the “thinking” became embedded in the chip itself—a technological breakthrough that enabled personal computers, Takayama said.
“We have literally made a microfluidic integrated circuit,” said Bobak Mosadegh, a doctoral student in Takayama’s lab who is first author of the paper.
The external controls that power today’s microfluidic devices can be cumbersome. Each valve on a chip (and there could be dozens of them) requires its own electromechanical push from an off-chip actuator or pump. This has made it difficult to shrink microfluidic systems to palm- or fingertip-sized diagnostic devices.
The Takayama lab’s innovation is a step in this direction. His research group has devised a strategy to produce the fluidic counterparts of key electrical components including transistors, diodes, resistors and capacitors, and to efficiently network these components to automatically regulate fluid flow within the device.
These components are made using conventional techniques, so they are compatible with all other microfluidic components such as mixers, filters and cell culture chambers, the researchers say.
“We’ve made a versatile control system,” Mosadegh said. “We envision that this technology will become a platform for researchers and companies in the microfluidics field to develop sophisticated self-controlled microfluidic devices that automatically process biofluids such as blood and pharmaceuticals for diagnostics or other applications.
“Just as the integrated circuit brought the digital information processing power of computers to the people, we envision our microfluidic analog will be able to do the same for cellular and biochemical information.”
The paper is titled “Integrated Elastomeric Components for Autonomous Regulation of Sequential and Oscillatory Flow Switching in Microfluidic Devices.” This research is funded by the National Institutes of Health, the U.S. Department of Education and the National Institute for Dental and Craniofacial Research. Also contributing were researchers from the U-M departments of Biomedical Engineering and Mechanical Engineering as well as the Macromolecular Science and Engineering Center.
The university is pursuing patent protection for the intellectual property, and is seeking commercialization partners to help bring the technology to market.Michigan Engineering:
Nicole Casal Moore | EurekAlert!
Basque researchers turn light upside down
23.02.2018 | Elhuyar Fundazioa
Attoseconds break into atomic interior
23.02.2018 | Max-Planck-Institut für Quantenoptik
A newly developed laser technology has enabled physicists in the Laboratory for Attosecond Physics (jointly run by LMU Munich and the Max Planck Institute of Quantum Optics) to generate attosecond bursts of high-energy photons of unprecedented intensity. This has made it possible to observe the interaction of multiple photons in a single such pulse with electrons in the inner orbital shell of an atom.
In order to observe the ultrafast electron motion in the inner shells of atoms with short light pulses, the pulses must not only be ultrashort, but very...
A group of researchers led by Andrea Cavalleri at the Max Planck Institute for Structure and Dynamics of Matter (MPSD) in Hamburg has demonstrated a new method enabling precise measurements of the interatomic forces that hold crystalline solids together. The paper Probing the Interatomic Potential of Solids by Strong-Field Nonlinear Phononics, published online in Nature, explains how a terahertz-frequency laser pulse can drive very large deformations of the crystal.
By measuring the highly unusual atomic trajectories under extreme electromagnetic transients, the MPSD group could reconstruct how rigid the atomic bonds are...
Quantum computers may one day solve algorithmic problems which even the biggest supercomputers today can’t manage. But how do you test a quantum computer to...
For the first time, a team of researchers at the Max-Planck Institute (MPI) for Polymer Research in Mainz, Germany, has succeeded in making an integrated circuit (IC) from just a monolayer of a semiconducting polymer via a bottom-up, self-assembly approach.
In the self-assembly process, the semiconducting polymer arranges itself into an ordered monolayer in a transistor. The transistors are binary switches used...
Breakthrough provides a new concept of the design of molecular motors, sensors and electricity generators at nanoscale
Researchers from the Institute of Organic Chemistry and Biochemistry of the CAS (IOCB Prague), Institute of Physics of the CAS (IP CAS) and Palacký University...
15.02.2018 | Event News
13.02.2018 | Event News
12.02.2018 | Event News
23.02.2018 | Physics and Astronomy
23.02.2018 | Health and Medicine
23.02.2018 | Physics and Astronomy