Its potential, however, could still increase significantly due to an invention recently made by a team of interdisciplinary working physicists.
Published as cover story in the current issue of the open access Journal "Optics Express", the researchers from Prof. Käs' group in Leipzig, in collaboration with researchers in Jena and Cambridge present the Optical Cell Rotator (OCR), a novel tool for the contact-free orientation of biological samples using laser radiation.
According to first author Moritz Kreysing the new technology could be the missing key to allow for the realization of single-cell optical tomography, which has been shown in principle but not in any useful implementation.
In contrast to the current standards for 3D imaging of cells, namely confocal and deconvolution microscopy, tomographic imaging provides maximum resolution in all three dimensions. To achieve this feat specimens are rotated stepwise and imaged from multiple angles. Using this data a computer is able to reconstruct a three-dimensional model of the sample containing 2.5 times more information than traditionally accessible.
The Optical Cell Rotator is of fundamental importance in this context for the integrity of living samples. While the orientation of cells previously required their exposure to either strong electric fields or unphysiological mechanical tools, the new device promises a much more gentle handling of the sensitive material. Thus, OCR is probably most useful for the investigation of stem cells, which are notoriously sensitive to handling.http://www.opticsinfobase.org/oe/viewmedia.cfm?uri=oe-16-21-16984&seq=0
Dr. Bärbel Adams | idw
Basque researchers turn light upside down
23.02.2018 | Elhuyar Fundazioa
Attoseconds break into atomic interior
23.02.2018 | Max-Planck-Institut für Quantenoptik
A newly developed laser technology has enabled physicists in the Laboratory for Attosecond Physics (jointly run by LMU Munich and the Max Planck Institute of Quantum Optics) to generate attosecond bursts of high-energy photons of unprecedented intensity. This has made it possible to observe the interaction of multiple photons in a single such pulse with electrons in the inner orbital shell of an atom.
In order to observe the ultrafast electron motion in the inner shells of atoms with short light pulses, the pulses must not only be ultrashort, but very...
A group of researchers led by Andrea Cavalleri at the Max Planck Institute for Structure and Dynamics of Matter (MPSD) in Hamburg has demonstrated a new method enabling precise measurements of the interatomic forces that hold crystalline solids together. The paper Probing the Interatomic Potential of Solids by Strong-Field Nonlinear Phononics, published online in Nature, explains how a terahertz-frequency laser pulse can drive very large deformations of the crystal.
By measuring the highly unusual atomic trajectories under extreme electromagnetic transients, the MPSD group could reconstruct how rigid the atomic bonds are...
Quantum computers may one day solve algorithmic problems which even the biggest supercomputers today can’t manage. But how do you test a quantum computer to...
For the first time, a team of researchers at the Max-Planck Institute (MPI) for Polymer Research in Mainz, Germany, has succeeded in making an integrated circuit (IC) from just a monolayer of a semiconducting polymer via a bottom-up, self-assembly approach.
In the self-assembly process, the semiconducting polymer arranges itself into an ordered monolayer in a transistor. The transistors are binary switches used...
Breakthrough provides a new concept of the design of molecular motors, sensors and electricity generators at nanoscale
Researchers from the Institute of Organic Chemistry and Biochemistry of the CAS (IOCB Prague), Institute of Physics of the CAS (IP CAS) and Palacký University...
15.02.2018 | Event News
13.02.2018 | Event News
12.02.2018 | Event News
23.02.2018 | Physics and Astronomy
23.02.2018 | Health and Medicine
23.02.2018 | Physics and Astronomy