Co-senior author John Rogers, the Lee J. Flory-Founder Chair in Engineering Innovation and a professor of materials science and engineering at Illinois, and his team will publish their breakthrough in the cover story of the March 24 issue of Science Translational Medicine.
Several treatments are available for hearts that dance to their own tempo, ranging from pacemaker implants to cardiac ablation therapy, a process that selectively targets and destroys clusters of arrhythmic cells. Current techniques require multiple electrodes placed on the tissue in a time-consuming, point-by-point process to construct a patchwork cardiac map. In addition, the difficulty of connecting rigid, flat sensors to soft, curved tissue impedes the electrodes’ ability to monitor and stimulate the heart.Rogers and his team have built a flexible sensor array that can wrap around the heart to map large areas of tissue at once. The array contains 2,016 silicon nanomembrane transistors, each monitoring electricity coursing through a beating heart.
“We believe that this technology may herald a new generation of devices for localizing and treating abnormal heart rhythms,” said co-sernior author Brian Litt, of the University of Pennsylvania.
“This allows us to apply the full power of silicon electronics directly to the tissue,” said Rogers, a renowned researcher in the area of flexible, stretchable electronics. As the first class of flexible electronics that can directly integrate with bodily tissues, “these approaches might have the potential to redefine design strategies for advanced surgical devices, implants, prosthetics and more,” he said.
The biocompatible circuits – the first ones unperturbed by immersion in the body’s salty fluids – represent a culmination of seven years of flexible electronics study by Rogers’ group. The researchers build circuits from ultrathin, single-crystal silicon on a flexible or stretchy substrate, like a sheet of plastic or rubber. The nanometer thinness of the silicon layer makes it possible to bend and fold the normally rigid semiconductor.
“If you can create a circuit that’s compliant and bendable, you can integrate it very effectively with soft surfaces in the body,” such as the irregular, constantly moving curves of the heart, Rogers said.
Collaborations with a theoretical mechanics group at Northwestern University, led by Younggang Huang, yielded important insights into the designs.
The patchwork grid of cardiac sensors adheres to the moist surfaces of the heart on its own, with no need for probes or adhesives, and lifts off easily. The array of hundreds of sensors gives cardiac surgeons a more complete picture of the heart’s electrical activity so they can quickly find and fix any short circuits. In fact, the cardiac device boasts the highest transistor resolution of any class of flexible electronics for non-display applications.
The team’s next step is to adapt the technology for use with non-invasive catheter procedures, Rogers said. The U. of I. and Pennsylvania teams also are exploring applications for the arrays in neuroscience, applying grids to brain surfaces to study conditions of unusual electrical activity, such as epilepsy.
“It sets out a new design paradigm for interfacing electronics to the human body, with a multitude of possible applications in human health,” Rogers said.
This work was supported by the U.S. Department of Energy, a National Security Science and Engineering Faculty Fellowship, the National Institutes of Health and the Klingenstein Foundation.
Editor’s note: To contact John Rogers, call 217-244-4979; e-mail email@example.com
Liz Ahlberg | University of Illinois
Further reports about: > Electronic Systems > Epilepsy > Ferchau Engineering > Flexible Arbeitszeiten > Illinois River Watershed > Medicine > Off-Beat > Science TV > beating heart > cardiac ablation therapy > electrical activity > flat sensors > flexible electronics > multiple electrodes > rhythm > transistor array
Strathclyde-led research develops world's highest gain high-power laser amplifier
29.05.2017 | University of Strathclyde
Camera on NASA's Lunar Orbiter survived 2014 meteoroid hit
29.05.2017 | NASA/Goddard Space Flight Center
The world's highest gain high power laser amplifier - by many orders of magnitude - has been developed in research led at the University of Strathclyde.
The researchers demonstrated the feasibility of using plasma to amplify short laser pulses of picojoule-level energy up to 100 millijoules, which is a 'gain'...
Staphylococcus aureus is a feared pathogen (MRSA, multi-resistant S. aureus) due to frequent resistances against many antibiotics, especially in hospital infections. Researchers at the Paul-Ehrlich-Institut have identified immunological processes that prevent a successful immune response directed against the pathogenic agent. The delivery of bacterial proteins with RNA adjuvant or messenger RNA (mRNA) into immune cells allows the re-direction of the immune response towards an active defense against S. aureus. This could be of significant importance for the development of an effective vaccine. PLOS Pathogens has published these research results online on 25 May 2017.
Staphylococcus aureus (S. aureus) is a bacterium that colonizes by far more than half of the skin and the mucosa of adults, usually without causing infections....
Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.
The quantum computer has fuelled the imagination of scientists for decades: It is based on fundamentally different phenomena than a conventional computer....
An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.
We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...
Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.
Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...
24.05.2017 | Event News
23.05.2017 | Event News
22.05.2017 | Event News
29.05.2017 | Physics and Astronomy
29.05.2017 | Physics and Astronomy
29.05.2017 | Earth Sciences