Ultrasound-stimulated microbubbles have been showing promise in recent years as a non-invasive way to break up dangerous blood clots. But though many researchers have studied the effectiveness of this technique, not much was understood about why it works.
Time lapse image of a bubble (purple) burrowing into the network of a clot. The bubble is initially at rest in the fluid next to the clot. Exposure to ultrasound causes the bubble to shoot from left to right, penetrating the clot and causing damage to it in the process.
Now a team of researchers in Toronto has collected the first direct evidence showing how these wiggling microbubbles cause a blood clot’s demise. The team’s findings are featured in the AIP Publishing journal Applied Physics Letters.
Previous work on this technique, which is called sonothrombolysis, has focused on indirect indications of its effectiveness, including how much a blood clot shrinks or how well blood flow is restored following the procedure. The Toronto team, which included researchers from the University of Toronto and the Sunnybrook Research Institute, tried to catch the clot-killing process in action. Using high-speed photography and a 3-D microscopy technique, researchers discovered that stimulating the microbubbles with ultrasonic pulses pushes the bubbles toward the clots. The bubbles deform the clots’ boundaries then begin to burrow into them, creating fluid-filled tunnels that break the clots up from the inside out.
These improvements in the understanding of how sonothrombolysis works will help researchers develop more sophisticated methods of breaking up blood clots, said lead author Christopher Acconcia.
Efforts so far “may only be scratching the surface with respect to effectiveness,” said Acconcia. “Our findings provide a tool that can be used to develop more sophisticated sonothrombolysis techniques, which may lead to new tools to safely and efficiently dissolve clots in a clinical setting.”
The article, "Interactions between ultrasound stimulated microbubbles and fibrin clots" by Christopher Acconcia, Ben Y. C. Leung, Kullervo Hynynen and David E. Goertz appears in the journal Applied Physics Letters. See: http://dx.doi.org/10.1063/1.4816750
Jason Socrates Bardi | Newswise
Study offers new theoretical approach to describing non-equilibrium phase transitions
27.04.2017 | DOE/Argonne National Laboratory
SwRI-led team discovers lull in Mars' giant impact history
26.04.2017 | Southwest Research Institute
More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.
Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...
Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.
"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...
The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.
Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...
The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...
Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.
Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...
28.04.2017 | Event News
20.04.2017 | Event News
18.04.2017 | Event News
28.04.2017 | Medical Engineering
28.04.2017 | Earth Sciences
28.04.2017 | Life Sciences