The model provides a tool in the quest to gain a better understanding of the mechanisms behind this incurable degenerative disorder.
Researchers from IUPUI (Indiana University-Purdue University Indianapolis) reduced the complex biology of the basal ganglia, a part of the brain involved in voluntary motor control, down to a key system of two interconnected cells. The cells were linked together in an inhibitory relationship, meaning a signal from one cell would suppress the second cell’s firing. The team ran simulations of the two-cell system while tinkering with the parameters of the model.
For example, since levels of the neurotransmitter dopamine decrease in Parkinson’s patients, increasing the inhibitory coupling strength between cells, the team tested how the strength of the inhibitory connection affected the cells’ synchronization.
In a paper in the AIP’s journal Chaos, the researchers identified specific ranges of coupling strength most likely to lead to bursts of intermittently synchronized firings.
The team also produced squiggly-lined graphs showing how the complex interactions between slow-changing variables such as calcium ion concentration can cause intermittent synchronization of the two cells. Although the model is based on a neural network known to be affected by Parkinson’s disease, the authors believe that their mathematical model might also yield insights into the operation of more generic neural systems.
Article: “Intermittent synchronization in a network of bursting neurons” is accepted for publication in Chaos: An Interdisciplinary Journal of Nonlinear Science.
Authors: Choongseok Park (1) and Leonid L. Rubchinsky (1,2).(1) Department of Mathematical Sciences and Center for Mathematical Biosciences, Indiana University-Purdue University, Indianapolis
(2) Stark Neurosciences Research Institute, Indiana University School of Medicine
Catherine Meyers | EurekAlert!
New manifestation of magnetic monopoles discovered
08.12.2017 | Institute of Science and Technology Austria
NASA's SuperTIGER balloon flies again to study heavy cosmic particles
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The miniaturization of the current technology of storage media is hindered by fundamental limits of quantum mechanics. A new approach consists in using so-called spin-crossover molecules as the smallest possible storage unit. Similar to normal hard drives, these special molecules can save information via their magnetic state. A research team from Kiel University has now managed to successfully place a new class of spin-crossover molecules onto a surface and to improve the molecule’s storage capacity. The storage density of conventional hard drives could therefore theoretically be increased by more than one hundred fold. The study has been published in the scientific journal Nano Letters.
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With innovative experiments, researchers at the Helmholtz-Zentrums Geesthacht and the Technical University Hamburg unravel why tiny metallic structures are extremely strong
Light-weight and simultaneously strong – porous metallic nanomaterials promise interesting applications as, for instance, for future aeroplanes with enhanced...
An interdisciplinary group of researchers interfaced individual bacteria with a computer to build a hybrid bio-digital circuit - Study published in Nature Communications
Scientists at the Institute of Science and Technology Austria (IST Austria) have managed to control the behavior of individual bacteria by connecting them to a...
Physicists in the Laboratory for Attosecond Physics (run jointly by LMU Munich and the Max Planck Institute for Quantum Optics) have developed an attosecond electron microscope that allows them to visualize the dispersion of light in time and space, and observe the motions of electrons in atoms.
The most basic of all physical interactions in nature is that between light and matter. This interaction takes place in attosecond times (i.e. billionths of a...
Transistors based on carbon nanostructures: what sounds like a futuristic dream could be reality in just a few years' time. An international research team working with Empa has now succeeded in producing nanotransistors from graphene ribbons that are only a few atoms wide, as reported in the current issue of the trade journal "Nature Communications."
Graphene ribbons that are only a few atoms wide, so-called graphene nanoribbons, have special electrical properties that make them promising candidates for the...
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08.12.2017 | Information Technology