Researchers from the Institute of Photonic Sciences (ICFO), in collaboration with the CSIC and Macquarie University in Australia, have developed a new technique, similar to the MRI but with a much higher resolution and sensitivity, which has the ability to scan individual cells.
In an article published in Nature Nanotech, and highlighted by Nature, ICFO Prof. Romain Quidant explains how this was accomplished using artificial atoms, diamond nanoparticles doped with nitrogen impurity, to probe very weak magnetic fields such as those generated in some biological molecules.
The conventional MRI registers the magnetic fields of atomic nuclei in our bodies which have been previously excited by an external electromagnetic field. The collective response of all of these atoms makes it possible to diagnose and monitor the evolution of certain diseases. However, this conventional technique has a diagnostic resolution on a millimetric scale. Smaller objects do not give enough signal to be measured.
The innovative technique proposed by the group led by Dr. Quidant significantly improves the resolution at the nanometer scale (nearly one million times smaller than the millimeter), making it possible to measure very weak magnetic fields, such as those created by proteins. "Our approach opens the door for the performance of magnetic resonances on isolated cells which will offer new sources of information and allow us to better understand the intracellular processes, enabling noninvasive diagnosis," explains Michael Geiselmann, ICFO researcher who conducted the experiment. Until now, it has only been possible to reach this resolution in the laboratory, using individual atoms at temperatures close to the absolute zero (approx. -273 degrees Celsius.)
Individual atoms are structures that are highly sensitive to their environment, with a great ability to detect nearby electromagnetic fields. The challenge these atoms present is that they are so small and volatile that in order to be manipulated, they must be cooled to temperatures near the absolute zero. This complex process requires an environment that is so restrictive that it makes individual atoms unviable for potential medical applications. Artificial atoms used by Quidant and his team are formed by a nitrogen impurity captured within a small diamond crystal. "This impurity has the same sensitivity as an individual atom but is very stable at room temperature due to its encapsulation. This diamond shell allows us to handle the nitrogen impurity in a biological environment and, therefore, enables us to scan cells" argues Dr. Quidant.
To trap and manipulate these artificial atoms, researchers use laser light. The laser works like tweezers, leading the atoms above the surface of the object to study and extract information from its tiny magnetic fields.
The emergence of this new technique could revolutionize the field of medical imaging, allowing for substantially higher sensitivity in clinical analysis, an improved capacity for early detection of diseases, and thus a higher probability for successful treatment.
This research has been possible thanks to the support of the private foundation Cellex Barcelona.
ICFO-The Institute of Photonic Sciences was created in 2002 by the government of Catalonia and the Technical University of Catalonia. ICFO is a center of research excellence devoted to the sciences and technologies of light with a triple mission: to conduct frontier research, train the next generation of scientists and technologists, and provide knowledge and technology transfer. As part of ICFO's goal to usher advances "made at ICFO" into society, the institute actively promotes the creation of spin-off companies by ICFO researchers.
Research at ICFO targets the forefront of science and technology based on light with programs directed at applications in Health, Renewable Energies, Information Technologies, Security and Industrial processes, among others. The center currently hosts more than 250 researchers and PhD students working in more than 60 different laboratories. All research groups and facilities are located in a dedicated 14.000 m2 building situated in the Mediterranean Technology Park in the metropolitan area of Barcelona.
ICFO researchers publish in the most prestigious journals and collaborate with a wide range of companies around the world. In recognition of research excellence, ICFO has been awarded the elite Severo Ochoa distinction by the Government of Spain. Foundation Cellex finances the NEST program at ICFO which makes possible many ambitious frontier research projects.
Albert Mundet | EurekAlert!
Electrocatalysis can advance green transition
23.01.2017 | Technical University of Denmark
Quantum optical sensor for the first time tested in space – with a laser system from Berlin
23.01.2017 | Ferdinand-Braun-Institut Leibniz-Institut für Höchstfrequenztechnik
For the first time ever, a cloud of ultra-cold atoms has been successfully created in space on board of a sounding rocket. The MAIUS mission demonstrates that quantum optical sensors can be operated even in harsh environments like space – a prerequi-site for finding answers to the most challenging questions of fundamental physics and an important innovation driver for everyday applications.
According to Albert Einstein's Equivalence Principle, all bodies are accelerated at the same rate by the Earth's gravity, regardless of their properties. This...
An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...
Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...
Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.
While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...
Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales
Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...
19.01.2017 | Event News
10.01.2017 | Event News
09.01.2017 | Event News
23.01.2017 | Health and Medicine
23.01.2017 | Physics and Astronomy
23.01.2017 | Process Engineering