According to The Arthritis Society, the second most common form of arthritis after osteoarthritis is "diffuse idiopathic skeletal hyperostosis" or DISH. It affects between six and 12 percent of North Americans, usually people older than 50. DISH is classified as a form of degenerative arthritis and is characterized by the formation of excessive mineral deposits along the sides of the vertebrae in the neck and back. Symptoms of DISH include spine pain and stiffness and in advanced cases, difficulty swallowing and damage to spinal nerves. The cause of DISH is unknown and there are no specific treatments.
Now researchers at Western University's Bone and Joint Initiative, with collaborator Doo-Sup Choi at the Mayo Clinic in Rochester, Minnesota have discovered the first-ever mouse model of this disease. The research is published online in the Journal of Bone and Mineral Research.
"This model will allow us for the first time to uncover the mechanisms underlying DISH and related disorders. Knowledge of these mechanisms will ultimately allow us to test novel pharmacological treatments to reverse or slow the development of DISH in humans," says corresponding author Cheryle Séguin of the Skeletal Biology Laboratories and the Department of Physiology and Pharmacology at Western's Schulich School of Medicine & Dentistry.
Graduate student Derek Bone, working under the supervision of pharmacologist James Hammond, was studying mice that had been genetically modified to lack a specific membrane protein that transports adenosine when he noticed that these mice developed abnormal calcification (mineralization) of spinal structures.
Changes in the backbone of these mice were characterized by an interdisciplinary team which included: Sumeeta Warraich, Diana Quinonez, Hisataka Ii, Maria Drangova, David Holdsworth and Jeff Dixon. Their findings established that spinal mineralization in these mice resembles DISH in humans and point to a role for adenosine in causing abnormal mineralization in DISH.
These studies were funded by grants from the Canadian Institutes of Health Research and the Canadian Arthritis Network (CAN). Séguin is supported by a Network Scholar Award from The Arthritis Society and CAN.
Kathy Wallis | Source: EurekAlert!
Further information: www.uwo.ca
Further Reports about: Arthritis > Arthritis Society > Canadian Light Source > degenerative arthritis > diffuse idiopathic skeletal hyperostosis > DISH > mineral deposits > Mineral Research > mineralization > spinal nerves
More articles from Health and Medicine:
Study shows that insomnia may cause dysfunction in emotional brain circuitry
23.05.2013 | American Academy of Sleep Medicine
Changing cancer's environment to halt its spread
22.05.2013 | Boston Children's Hospital
New indicator molecules visualise the activation of auto-aggressive T cells in the body as never before
Biological processes are generally based on events at the molecular and cellular level. To understand what happens in the course of infections, diseases or normal bodily functions, scientists would need to examine individual cells and their activity directly in the tissue.
The development of new microscopes and fluorescent dyes in ...
A fried breakfast food popular in Spain provided the inspiration for the development of doughnut-shaped droplets that may provide scientists with a new approach for studying fundamental issues in physics, mathematics and materials.
The doughnut-shaped droplets, a shape known as toroidal, are formed from two dissimilar liquids using a simple rotating stage and an injection needle. About a millimeter in overall size, the droplets are produced individually, their shapes maintained by a surrounding springy material made of polymers.
Droplets in this toroidal shape made ...
Frauhofer FEP will present a novel roll-to-roll manufacturing process for high-barriers and functional films for flexible displays at the SID DisplayWeek 2013 in Vancouver – the International showcase for the Display Industry.
Displays that are flexible and paper thin at the same time?! What might still seem like science fiction will be a major topic at the SID Display Week 2013 that currently takes place in Vancouver in Canada.
High manufacturing cost and a short lifetime are still a major obstacle on ...
University of Würzburg physicists have succeeded in creating a new type of laser.
Its operation principle is completely different from conventional devices, which opens up the possibility of a significantly reduced energy input requirement. The researchers report their work in the current issue of Nature.
It also emits light the waves of which are in phase with one another: the polariton laser, developed ...
Innsbruck physicists led by Rainer Blatt and Peter Zoller experimentally gained a deep insight into the nature of quantum mechanical phase transitions.
They are the first scientists that simulated the competition between two rival dynamical processes at a novel type of transition between two quantum mechanical orders. They have published the results of their work in the journal Nature Physics.
“When water boils, its molecules are released as vapor. We call this ...
23.05.2013 | Physics and Astronomy
23.05.2013 | Health and Medicine
23.05.2013 | Ecology, The Environment and Conservation
17.05.2013 | Event News
15.05.2013 | Event News
08.05.2013 | Event News