Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Yale-developed test can help predict and diagnose preeclampsia

04.02.2010
Researchers at Yale School of Medicine have developed a simple urine test to rapidly predict and diagnose preeclampsia, a common, but serious hypertensive complication of pregnancy.

Dubbed the "Congo Red Dot Test" by the research team, the test accurately predicted preeclampsia in a study of 347 pregnant women, allowing health care providers to offer better preventive care to pregnant women. The research will be presented February 4 at the Annual Scientific Meeting of the Society for Maternal Fetal Medicine (SMFM) in Chicago.

The World Health Organization estimates that about 63,000 pregnant women die each year because of severe preeclampsia, as well as a related condition called eclampsia, which can cause sudden, convulsive seizures.

"There is a critical need in the developing world for low-cost diagnostics for preeclampsia," said lead researcher Irina Buhimschi, M.D., associate professor in the Department of Obstetrics, Gynecology & Reproductive Sciences at Yale School of Medicine. "This test will help identify high-risk patients that should be transported from remote settings to facilities where there is access to specialized care for preeclampsia, such as magnesium sulfate therapy."

Buhimschi said that despite its effectiveness in preventing eclamptic seizures, magnesium sulfate is underutilized in developing countries. This is due in part to the lack of consistent and low-cost ways to identify preeclampsia patients who are in need of intervention, which the test could provide. She said that the test could also identify women who needed to deliver their babies immediately, in turn reducing the incidence of unnecessary early birth, because delivery is the only effective treatment for preeclampsia.

The team also found that the Congo Red Dot Test could be used as a marker for assessing misfolded proteins. The test is based on a common red dye, originally used to stain textiles, that sticks to misfolded proteins. Previous studies by Buhimschi and her team have found that preeclampsia is a pregnancy-specific protein misfolding disease.

"In this new work, we have seen a link between preeclampsia and other disorders caused by misfolded proteins such as Alzheimer's or prion disease," said Buhimschi. "This may provide the foundation for new therapeutic approaches to reduce the burden of this disorder."

Other Yale School of Medicine authors on the study included Edmund Funai, Guomao Zhao, Antonette Dulay, Sarah Lee, Christina Han, Erika Werner, Stephen Thung and Catalin Buhimschi.

The research was funded by a McKern Award for Perinatal Research.

Karen N. Peart | EurekAlert!
Further information:
http://www.yale.edu

More articles from Health and Medicine:

nachricht One gene closer to regenerative therapy for muscular disorders
01.06.2017 | Cincinnati Children's Hospital Medical Center

nachricht The gut microbiota plays a key role in treatment with classic diabetes medication
01.06.2017 | University of Gothenburg

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Can we see monkeys from space? Emerging technologies to map biodiversity

An international team of scientists has proposed a new multi-disciplinary approach in which an array of new technologies will allow us to map biodiversity and the risks that wildlife is facing at the scale of whole landscapes. The findings are published in Nature Ecology and Evolution. This international research is led by the Kunming Institute of Zoology from China, University of East Anglia, University of Leicester and the Leibniz Institute for Zoo and Wildlife Research.

Using a combination of satellite and ground data, the team proposes that it is now possible to map biodiversity with an accuracy that has not been previously...

Im Focus: Climate satellite: Tracking methane with robust laser technology

Heatwaves in the Arctic, longer periods of vegetation in Europe, severe floods in West Africa – starting in 2021, scientists want to explore the emissions of the greenhouse gas methane with the German-French satellite MERLIN. This is made possible by a new robust laser system of the Fraunhofer Institute for Laser Technology ILT in Aachen, which achieves unprecedented measurement accuracy.

Methane is primarily the result of the decomposition of organic matter. The gas has a 25 times greater warming potential than carbon dioxide, but is not as...

Im Focus: How protons move through a fuel cell

Hydrogen is regarded as the energy source of the future: It is produced with solar power and can be used to generate heat and electricity in fuel cells. Empa researchers have now succeeded in decoding the movement of hydrogen ions in crystals – a key step towards more efficient energy conversion in the hydrogen industry of tomorrow.

As charge carriers, electrons and ions play the leading role in electrochemical energy storage devices and converters such as batteries and fuel cells. Proton...

Im Focus: A unique data centre for cosmological simulations

Scientists from the Excellence Cluster Universe at the Ludwig-Maximilians-Universität Munich have establised "Cosmowebportal", a unique data centre for cosmological simulations located at the Leibniz Supercomputing Centre (LRZ) of the Bavarian Academy of Sciences. The complete results of a series of large hydrodynamical cosmological simulations are available, with data volumes typically exceeding several hundred terabytes. Scientists worldwide can interactively explore these complex simulations via a web interface and directly access the results.

With current telescopes, scientists can observe our Universe’s galaxies and galaxy clusters and their distribution along an invisible cosmic web. From the...

Im Focus: Scientists develop molecular thermometer for contactless measurement using infrared light

Temperature measurements possible even on the smallest scale / Molecular ruby for use in material sciences, biology, and medicine

Chemists at Johannes Gutenberg University Mainz (JGU) in cooperation with researchers of the German Federal Institute for Materials Research and Testing (BAM)...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Plants are networkers

19.06.2017 | Event News

Digital Survival Training for Executives

13.06.2017 | Event News

Global Learning Council Summit 2017

13.06.2017 | Event News

 
Latest News

Quantum thermometer or optical refrigerator?

23.06.2017 | Physics and Astronomy

A 100-year-old physics problem has been solved at EPFL

23.06.2017 | Physics and Astronomy

Equipping form with function

23.06.2017 | Information Technology

VideoLinks
B2B-VideoLinks
More VideoLinks >>>