Results, now published online in the Journal of Surgical Research in a paper titled "The Battle of the Sexes: Women Win Out in Gastrointestinal Surgery," shed light on major differences between patients which impact treatment success, and open pathways to creating new therapies aimed at improving survivability of surgical patients.
"Science is just now understanding that one size does not necessarily fit all, as each individual person may respond differently to disease and treatment. However, medical outcomes could be optimized by tailoring therapies based upon each individual's unique genetic make-up as well as other characteristics. Gender is among the most important traits," said Carrie Y. Peterson, MD, a surgical resident physician at UC San Diego Health System who is combining her clinical residency with scientific research training, and first author of the paper.
Peterson and colleagues performed a retrospective review of the National Institute of Health database from 1997 to 2007 and identified a total of 307,124 patients with gastrointestinal surgeries. Over 50 percent of them were women, who, according to the study, are 21.1 percent less likely to die after major stomach or intestinal surgery than men. In particular, female patients had lower mortality in gastric, small intestine, large intestine, hepatic, and pancreatic surgeries.
To control for the effect of menopause, researchers analyzed the rates of in-hospital deaths for patients over the age of 50 and those patients who were between 18 and 40 years old. Women between 18 and 40 were 33 percent less likely to die than men of a similar age, and women over the age of 50 were 17 percent less likely to die than age-matched men. "The results suggest that female hormones might enhance the immune system – a process previously shown in animal models and also observed in trauma patients," said Peterson. "Thus, there is a hope that negating the effects of testosterone or giving estrogen to male patients could be considered part of a treatment plan."
Furthermore, researchers defined additional factors that might contribute to higher survivability rates in women. According to the data, females more frequently had operations performed for elective reasons (58.23 versus 53.57 percent), and were more likely to have their surgeries performed in teaching hospitals (52.01 versus 50.96), which often offer the latest therapies and additional patient care provided by residents.
"Women are probably more proactive with their health in general than men, have more reasons to seek health care, and access the system more readily. This may lead to addressing health care needs and surgical interventions earlier in the history of the disease, resulting in an elective operation," said David C. Chang, PhD, MPH, MBA, director of Outcomes Research in the Department of Surgery at the University of California, San Diego School of Medicine and senior author of the paper. "Men, in turn, may tend to delay presenting for a doctor visit until symptoms are severe and require urgent or complex intervention."
Additional authors were Hayley B. Osen, BA, Hop S. Tran Cao, MD, and Peter T. Yu, MD, Department of Surgery, University of California, San Diego.
Maja Gawronska | EurekAlert!
Resolving the mystery of preeclampsia
21.10.2016 | Universitätsklinikum Magdeburg
New potential cancer treatment using microwaves to target deep tumors
12.10.2016 | University of Texas at Arlington
Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.
"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...
In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.
A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...
By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.
"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...
COMPAMED has become the leading international marketplace for suppliers of medical manufacturing. The trade fair, which takes place every November and is co-located to MEDICA in Dusseldorf, has been steadily growing over the past years and shows that medical technology remains a rapidly growing market.
In 2016, the joint pavilion by the IVAM Microtechnology Network, the Product Market “High-tech for Medical Devices”, will be located in Hall 8a again and will...
'Ferroelectric' materials can switch between different states of electrical polarization in response to an external electric field. This flexibility means they show promise for many applications, for example in electronic devices and computer memory. Current ferroelectric materials are highly valued for their thermal and chemical stability and rapid electro-mechanical responses, but creating a material that is scalable down to the tiny sizes needed for technologies like silicon-based semiconductors (Si-based CMOS) has proven challenging.
Now, Hiroshi Funakubo and co-workers at the Tokyo Institute of Technology, in collaboration with researchers across Japan, have conducted experiments to...
14.10.2016 | Event News
14.10.2016 | Event News
12.10.2016 | Event News
21.10.2016 | Health and Medicine
21.10.2016 | Information Technology
21.10.2016 | Materials Sciences