Results, now published online in the Journal of Surgical Research in a paper titled "The Battle of the Sexes: Women Win Out in Gastrointestinal Surgery," shed light on major differences between patients which impact treatment success, and open pathways to creating new therapies aimed at improving survivability of surgical patients.
"Science is just now understanding that one size does not necessarily fit all, as each individual person may respond differently to disease and treatment. However, medical outcomes could be optimized by tailoring therapies based upon each individual's unique genetic make-up as well as other characteristics. Gender is among the most important traits," said Carrie Y. Peterson, MD, a surgical resident physician at UC San Diego Health System who is combining her clinical residency with scientific research training, and first author of the paper.
Peterson and colleagues performed a retrospective review of the National Institute of Health database from 1997 to 2007 and identified a total of 307,124 patients with gastrointestinal surgeries. Over 50 percent of them were women, who, according to the study, are 21.1 percent less likely to die after major stomach or intestinal surgery than men. In particular, female patients had lower mortality in gastric, small intestine, large intestine, hepatic, and pancreatic surgeries.
To control for the effect of menopause, researchers analyzed the rates of in-hospital deaths for patients over the age of 50 and those patients who were between 18 and 40 years old. Women between 18 and 40 were 33 percent less likely to die than men of a similar age, and women over the age of 50 were 17 percent less likely to die than age-matched men. "The results suggest that female hormones might enhance the immune system – a process previously shown in animal models and also observed in trauma patients," said Peterson. "Thus, there is a hope that negating the effects of testosterone or giving estrogen to male patients could be considered part of a treatment plan."
Furthermore, researchers defined additional factors that might contribute to higher survivability rates in women. According to the data, females more frequently had operations performed for elective reasons (58.23 versus 53.57 percent), and were more likely to have their surgeries performed in teaching hospitals (52.01 versus 50.96), which often offer the latest therapies and additional patient care provided by residents.
"Women are probably more proactive with their health in general than men, have more reasons to seek health care, and access the system more readily. This may lead to addressing health care needs and surgical interventions earlier in the history of the disease, resulting in an elective operation," said David C. Chang, PhD, MPH, MBA, director of Outcomes Research in the Department of Surgery at the University of California, San Diego School of Medicine and senior author of the paper. "Men, in turn, may tend to delay presenting for a doctor visit until symptoms are severe and require urgent or complex intervention."
Additional authors were Hayley B. Osen, BA, Hop S. Tran Cao, MD, and Peter T. Yu, MD, Department of Surgery, University of California, San Diego.
Maja Gawronska | EurekAlert!
One gene closer to regenerative therapy for muscular disorders
01.06.2017 | Cincinnati Children's Hospital Medical Center
The gut microbiota plays a key role in treatment with classic diabetes medication
01.06.2017 | University of Gothenburg
Heatwaves in the Arctic, longer periods of vegetation in Europe, severe floods in West Africa – starting in 2021, scientists want to explore the emissions of the greenhouse gas methane with the German-French satellite MERLIN. This is made possible by a new robust laser system of the Fraunhofer Institute for Laser Technology ILT in Aachen, which achieves unprecedented measurement accuracy.
Methane is primarily the result of the decomposition of organic matter. The gas has a 25 times greater warming potential than carbon dioxide, but is not as...
Hydrogen is regarded as the energy source of the future: It is produced with solar power and can be used to generate heat and electricity in fuel cells. Empa researchers have now succeeded in decoding the movement of hydrogen ions in crystals – a key step towards more efficient energy conversion in the hydrogen industry of tomorrow.
As charge carriers, electrons and ions play the leading role in electrochemical energy storage devices and converters such as batteries and fuel cells. Proton...
Scientists from the Excellence Cluster Universe at the Ludwig-Maximilians-Universität Munich have establised "Cosmowebportal", a unique data centre for cosmological simulations located at the Leibniz Supercomputing Centre (LRZ) of the Bavarian Academy of Sciences. The complete results of a series of large hydrodynamical cosmological simulations are available, with data volumes typically exceeding several hundred terabytes. Scientists worldwide can interactively explore these complex simulations via a web interface and directly access the results.
With current telescopes, scientists can observe our Universe’s galaxies and galaxy clusters and their distribution along an invisible cosmic web. From the...
Temperature measurements possible even on the smallest scale / Molecular ruby for use in material sciences, biology, and medicine
Chemists at Johannes Gutenberg University Mainz (JGU) in cooperation with researchers of the German Federal Institute for Materials Research and Testing (BAM)...
Germany counts high-precision manufacturing processes among its advantages as a location. It’s not just the aerospace and automotive industries that require almost waste-free, high-precision manufacturing to provide an efficient way of testing the shape and orientation tolerances of products. Since current inline measurement technology not yet provides the required accuracy, the Fraunhofer Institute for Laser Technology ILT is collaborating with four renowned industry partners in the INSPIRE project to develop inline sensors with a new accuracy class. Funded by the German Federal Ministry of Education and Research (BMBF), the project is scheduled to run until the end of 2019.
New Manufacturing Technologies for New Products
19.06.2017 | Event News
13.06.2017 | Event News
13.06.2017 | Event News
22.06.2017 | Physics and Astronomy
22.06.2017 | Physics and Astronomy
22.06.2017 | Materials Sciences