Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Women with HIV shown to have elevated resting energy expenditure

16.04.2013
Antiretroviral therapy does not affect resting energy expenditure among women with HIV, according to Journal of the Academy of Nutrition and Dietetics report

Studies have shown that about 10 percent of men infected with human immunodeficiency virus (HIV) have an elevated resting energy expenditure (REE). Their bodies use more kilocalories for basic functions including circulation, body temperature, and breathing.

Most studies have been conducted in men and those with solely women have had small sample sizes. A team of researchers has sought to rectify this with a matched, prospective, cross-sectional study. The results are featured in a new report published by the Journal of the Academy of Nutrition and Dietetics.

"To our knowledge, no studies have been conducted that dissect the effect of HIV infection versus antiretroviral therapy," says lead investigator Grace McComsey, MD, FIDSA, Chief Pediatric Infectious Diseases, Rheumatology and Global Health at Case Western Reserve University School of Medicine. "The purpose of our study was to compare REE in HIV-infected women who have never been on antiretroviral therapy (ART), those on ART with virologic suppression, those on ART with detectable HIV-1 RNA, and HIV-negative, healthy women." Antiretroviral therapy typically consists of at least three drugs to fight against fatal HIV effects and improve quality of life.

The study team recruited women from the John T. Carey Special Immunology Unit at University Hospitals Case Medical Center, an out-patient HIV clinic in Cleveland, Ohio between 2004 and 2011. The women were matched by age and body mass index (BMI). Healthy women who volunteered to participate in the control group were mostly hospital employees. In total, 87 women participated, 62 with HIV and 25 without.

All participants received a clinical evaluation for weight, height, and waist and hip measurements and responded to questions about their exercise habits and alcohol, tobacco, and drug use. Investigators determined their body composition and measured their oxygen consumption to determine REE. They also consulted medical records for further information about current medications and HIV diagnosis details.

The study produced the following significant findings:

REE is significantly higher in HIV-infected women who have never been on ART when compared to healthy women.

REE is significantly higher, when adjusted for body composition changes, in HIV-infected women who are on ART with undetectable HIV-1 RNA compared to healthy controls.

REE is significantly higher in HIV-infected women on ART with detectable HIV-1 RNA compared to controls.

REE was not different between the HIV-infected groups.

In addition analysis revealed that REE strongly correlates with two common equations used to predict energy expenditure and with body cell mass, BMI, and fat mass.

The investigators hypothesized that those with increased REE may have a greater absolute production of reactive oxygen species if tissue oxygen concentration also increases, leading to more oxidative stress. This needs to be investigated in future studies.

"We showed that REE is elevated in ART-naïve HIV-infected women and continues to be elevated when on effective ART, regardless of virologic suppression, when compared to age and BMI matched healthy women," says Dr. McComsey. "This suggests an effect of HIV infection itself and not antiretroviral therapy on REE. The exact mechanism by which this occurs is unknown, but could be due to heightened inflammation or immune activation, which occurs in HIV infection."

Dr. McComsey also notes the need for further study of ART initiation to assess the effect of HIV infection on REE and the effect of specific antiretrovirals on REE.

Eileen Leahy | EurekAlert!
Further information:
http://www.elsevier.com

More articles from Health and Medicine:

nachricht Team discovers how bacteria exploit a chink in the body's armor
20.01.2017 | University of Illinois at Urbana-Champaign

nachricht Rabies viruses reveal wiring in transparent brains
19.01.2017 | Rheinische Friedrich-Wilhelms-Universität Bonn

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Traffic jam in empty space

New success for Konstanz physicists in studying the quantum vacuum

An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...

Im Focus: How gut bacteria can make us ill

HZI researchers decipher infection mechanisms of Yersinia and immune responses of the host

Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...

Im Focus: Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.

While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...

Im Focus: Studying fundamental particles in materials

Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales

Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...

Im Focus: Designing Architecture with Solar Building Envelopes

Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.

As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Sustainable Water use in Agriculture in Eastern Europe and Central Asia

19.01.2017 | Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

 
Latest News

Helmholtz International Fellow Award for Sarah Amalia Teichmann

20.01.2017 | Awards Funding

An innovative high-performance material: biofibers made from green lacewing silk

20.01.2017 | Materials Sciences

Ion treatments for cardiac arrhythmia — Non-invasive alternative to catheter-based surgery

20.01.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>