Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Virginia Tech engineers introduce thermotherapy as a chemotherapy alternative

23.11.2010
Using hyperthermia, Virginia Tech engineering researchers and a colleague from India unveiled a new method to target and destroy cancerous cells. The research was presented at the 63rd annual meeting of the American Physical Society Nov. 23 in Long Beach, Calif.

The cancer treatment uses hyperthermia to elevate the temperature of tumor cells, while keeping the surrounding healthy tissue at a lower degree of body heat. The investigators used both in vitro and in vivo experiments to confirm their findings.

The collaborators are Monrudee Liangruksa, a Virginia Tech graduate student in engineering science and mechanics, and her thesis adviser, Ishwar Puri, professor and head of the department, along with Ranjan Ganguly of the department of power engineering at Iadavpur Univesity, Kolkata, India.

Liangruska of Bangkok, Thailand, presented the paper at the meeting.

In an interview prior to the presentation, Puri explained that to further perfect the technique they used ferrofluids to induce the hyperthermia. A ferrofluid is a liquid that becomes strongly magnetized in the presence of a magnetic field. The magnetic nanoparticles are suspended in the non-polar state.

"These fluids can then be magnetically targeted to cancerous tissues after intravenous application," Puri said. "The magnetic nanoparticles, each billionths of a meter in size, seep into the tissue of the tumor cell due to the high permeability of these vessels."

Afterwards, the magnetic nanoparticles are heated by exposing the tumor to a high frequency alternating magnetic field, causing the tissue's death by heating. This process is called magnetic fluid hyperthermia and they have nicknamed it thermotherapy.

Temperatures in the range of 41 to 45 degrees Celsius are enough to slow or halt the growth of cancerous tissue. However, without the process of magnetic fluid hyperthermia, these temperatures also destroy healthy cells.

"The ideal hyperthermia treatment sufficiently increases the temperature of the tumor cells for about 30 minutes while maintaining the healthy tissue temperature below 41 degrees Celsius," Puri said. "Our ferrofluid-based thermotherapy can be also accomplished through thermoablation, which typically heats tissues up to 56 degrees C to cause their death, coagulation, or carbonization by exposure to a noninvasive radio frequency, alternating current magnetic field. Local heat transfer from the nanoparticles increases the tissue temperature and ruptures the cell membranes."

Puri added that testing showed iron oxide nanoparticles are "the most biocompatible agents for magnetic fluid hyperthermia." Platinum and nickel also act as magnetic nanoparticles but they "are toxic and vulnerable" when exposed to oxygen.

The researchers plan to test their analytical approach by conducting experiments on various cancer cells in collaboration with Dr. Elankumaran Subbiah of the Virginia-Maryland School of Veterinary Medicine. A senior design team consisting of five engineering science and mechanics undergraduate Virginia Tech students is fabricating an apparatus for these tests.

Lynn Nystrom | EurekAlert!
Further information:
http://www.vt.edu

More articles from Health and Medicine:

nachricht Investigators may unlock mystery of how staph cells dodge the body's immune system
22.09.2017 | Cedars-Sinai Medical Center

nachricht Monitoring the heart's mitochondria to predict cardiac arrest?
21.09.2017 | Boston Children's Hospital

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: The pyrenoid is a carbon-fixing liquid droplet

Plants and algae use the enzyme Rubisco to fix carbon dioxide, removing it from the atmosphere and converting it into biomass. Algae have figured out a way to increase the efficiency of carbon fixation. They gather most of their Rubisco into a ball-shaped microcompartment called the pyrenoid, which they flood with a high local concentration of carbon dioxide. A team of scientists at Princeton University, the Carnegie Institution for Science, Stanford University and the Max Plank Institute of Biochemistry have unravelled the mysteries of how the pyrenoid is assembled. These insights can help to engineer crops that remove more carbon dioxide from the atmosphere while producing more food.

A warming planet

Im Focus: Highly precise wiring in the Cerebral Cortex

Our brains house extremely complex neuronal circuits, whose detailed structures are still largely unknown. This is especially true for the so-called cerebral cortex of mammals, where among other things vision, thoughts or spatial orientation are being computed. Here the rules by which nerve cells are connected to each other are only partly understood. A team of scientists around Moritz Helmstaedter at the Frankfiurt Max Planck Institute for Brain Research and Helene Schmidt (Humboldt University in Berlin) have now discovered a surprisingly precise nerve cell connectivity pattern in the part of the cerebral cortex that is responsible for orienting the individual animal or human in space.

The researchers report online in Nature (Schmidt et al., 2017. Axonal synapse sorting in medial entorhinal cortex, DOI: 10.1038/nature24005) that synapses in...

Im Focus: Tiny lasers from a gallery of whispers

New technique promises tunable laser devices

Whispering gallery mode (WGM) resonators are used to make tiny micro-lasers, sensors, switches, routers and other devices. These tiny structures rely on a...

Im Focus: Ultrafast snapshots of relaxing electrons in solids

Using ultrafast flashes of laser and x-ray radiation, scientists at the Max Planck Institute of Quantum Optics (Garching, Germany) took snapshots of the briefest electron motion inside a solid material to date. The electron motion lasted only 750 billionths of the billionth of a second before it fainted, setting a new record of human capability to capture ultrafast processes inside solids!

When x-rays shine onto solid materials or large molecules, an electron is pushed away from its original place near the nucleus of the atom, leaving a hole...

Im Focus: Quantum Sensors Decipher Magnetic Ordering in a New Semiconducting Material

For the first time, physicists have successfully imaged spiral magnetic ordering in a multiferroic material. These materials are considered highly promising candidates for future data storage media. The researchers were able to prove their findings using unique quantum sensors that were developed at Basel University and that can analyze electromagnetic fields on the nanometer scale. The results – obtained by scientists from the University of Basel’s Department of Physics, the Swiss Nanoscience Institute, the University of Montpellier and several laboratories from University Paris-Saclay – were recently published in the journal Nature.

Multiferroics are materials that simultaneously react to electric and magnetic fields. These two properties are rarely found together, and their combined...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

“Lasers in Composites Symposium” in Aachen – from Science to Application

19.09.2017 | Event News

I-ESA 2018 – Call for Papers

12.09.2017 | Event News

EMBO at Basel Life, a new conference on current and emerging life science research

06.09.2017 | Event News

 
Latest News

Rainbow colors reveal cell history: Uncovering β-cell heterogeneity

22.09.2017 | Life Sciences

Penn first in world to treat patient with new radiation technology

22.09.2017 | Medical Engineering

Calculating quietness

22.09.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>