Wounds may heal more quickly if exposed to low-intensity vibration, report researchers at the University of Illinois at Chicago.
The finding, in mice, may hold promise for the 18 million Americans who have type 2 diabetes, and especially the quarter of them who will eventually suffer from foot ulcers. Their wounds tend to heal slowly and can become chronic or worsen rapidly.
This is a photo of Eileen Weinheimer-Haus, first author, and Timothy Koh, principal investigator.
Credit: Roberta Dupuis-Devlin/University of Illinois at Chicago Photo Services
Timothy Koh, UIC professor of kinesiology and nutrition in the UIC College of Applied Health Sciences, was intrigued by studies at Stony Brook University in New York that used very low-intensity signals to accelerate bone regeneration.
"This technique is already in clinical trials to see if vibration can improve bone health and prevent osteoporosis," Koh said.
Koh and his coworkers at UIC collaborated with Stefan Judex of Stony Brook to investigate whether the same technique might improve wound healing in diabetes. The new study, using an experimental mouse model of diabetes, is published online in the journal PLOS One.
The low-amplitude vibrations are barely perceptible to touch.
"It's more like a buzz than an earthquake," said Eileen Weinheimer-Haus, UIC postdoctoral fellow in kinesiology and nutrition, the first author of the study.
The researchers found that wounds exposed to vibration five times a week for 30 minutes healed more quickly than wounds in mice of a control group.
Wounds exposed to vibration formed more granulation tissue, a type of tissue important early in the wound-healing process. Vibration helped tissue to form new blood vessels -- a process called angiogenesis -- and also led to increased expression of pro-healing growth factors and signaling molecules called chemokines, Weinheimer-Haus said.
"We know that chronic wounds in people with diabetes fail to form granulation tissue and have poor angiogenesis, and we believe these factors contribute to their wounds' failure to heal," said Koh. He and his colleagues want to determine whether the changes they see in cell populations and gene expression at wound sites underlie the observed improvement in healing.
"The exciting thing about this intervention is how easily it could be translated to people," Koh said. "It's a procedure that's non-invasive, doesn't require any drugs, and is already being tested in human trials to see if it's protective of bone loss." A clinical study, in collaboration with Dr. William Ennis, director of the Wound Healing Clinic at UIC, is planned, Koh said.
Ennis and Judex are co-authors on the PLOS One study, which was supported by National Institutes of Health grants R01GM092850 and T32DE018381.
Jeanne Galatzer-Levy | EurekAlert!
Zinc Deficiency Linked to Activation of Hedgehog Signaling Pathway
20.04.2015 | Rensselaer Polytechnic Institute (RPI)
UV light robot to clean hospital rooms could help stop spread of 'superbugs'
15.04.2015 | Texas A&M University
Max Planck researcher Buhalqem Mamtimin determines how much nitrogen oxide is released into the atmosphere from agriculturally used oases.
In order to make statements about current and future air pollution, scientists use models which simulate the Earth’s atmosphere. A lot of information such as...
Scientists at the Helmholtz-Zentrum Dresden-Rossendorf (HZDR) and the University of Konstanz are working on storing and processing information on the level of single molecules to create the smallest possible components that will combine autonomously to form a circuit. As recently reported in the academic journal Advanced Science, the researchers can switch on the current flow through a single molecule for the first time with the help of light.
Dr. Artur Erbe, physicist at the HZDR, is convinced that in the future molecular electronics will open the door for novel and increasingly smaller – while also...
Cells of the vascular system of vertebrates can fuse with themselves. This process, which occurs when a blood vessel is no longer necessary and pruned, has now been described on the cellular level by Prof. Markus Affolter from the Biozentrum of the University of Basel. The findings of this study have been published in the journal “PLoS Biology”.
The vascular system is the supply network of the human organism and delivers oxygen and nutrients to the last corners of the body. So far, research on the...
Astronomers from Chalmers University of Technology have used the giant telescope Alma to reveal an extremely powerful magnetic field very close to a supermassive black hole in a distant galaxy
Astronomers from Chalmers University of Technology have used the giant telescope Alma to reveal an extremely powerful magnetic field very close to a...
A team of physicists from MPQ, Caltech, and ICFO proposes the combination of nano-photonics with ultracold atoms for simulating quantum many-body systems and creating new states of matter.
Ultracold atoms in the so-called optical lattices, that are generated by crosswise superposition of laser beams, have been proven to be one of the most...
13.04.2015 | Event News
25.03.2015 | Event News
19.03.2015 | Event News
21.04.2015 | Materials Sciences
21.04.2015 | Earth Sciences
21.04.2015 | Studies and Analyses