Researchers in the Vanderbilt University Institute of Imaging Science (VUIIS) have achieved the first conclusive non-invasive measurement of neural signaling in the spinal cords of healthy human volunteers.
Their technique, described today in the journal eLife, may aid efforts to help patients recover from spinal cord injuries and other disorders affecting spinal cord function, including multiple sclerosis.
"We definitely hope that this work can be translated to address many neurological disorders," said the paper's first author, Robert Barry, Ph.D., a postdoctoral research fellow in the institute directed by senior author John Gore, Ph.D.
The researchers used ultra-high field functional magnetic resonance imaging (fMRI) to detect for the first time "resting state" signals between neural circuits in the human spinal column. These signals are continuously active, not in response to external stimuli.
"We see these background resting circuits as being inherent measures of function," said Gore, the Hertha Ramsey Cress Professor of Medicine, University Professor and vice chair of Research in the Department of Radiology and Radiological Sciences.
The technique may be valuable for understanding how spinal cord injury changes the "functional connectivity" between neural circuits, for example, and for assessing and monitoring recovery that occurs spontaneously or following various interventions.
"The hope is that when you have impaired function that there will be changes (in the signals)," Gore said. "We've already got evidence for that from other studies."
Studies of the "resting" brain reveal how neural circuits coordinate to control various functions and to produce different behaviors. The spinal cord has been more difficult to study because it is much smaller than the brain, and conventional fMRI isn't sensitive enough to pick up its signals.
The Vanderbilt team overcame this challenge by using an fMRI scanner with a 7 Tesla magnet, multichannel spinal cord coils, and advanced methods for acquiring and analyzing the images. One Tesla is roughly 20,000 times the strength of the magnetic field of the earth.
Co-authors Seth Smith, Ph.D., assistant professor, and Adrienne Dula, Ph.D., research instructor, both in the Department of Radiology and Radiological Sciences, are applying advanced imaging methods to better understand human spinal cord diseases such as multiple sclerosis, while Barry has expertise in the acquisition and analysis of functional data.
Craig Boerner | Eurek Alert!
GLUT5 fluorescent probe fingerprints cancer cells
20.04.2018 | Michigan Technological University
Scientists re-create brain neurons to study obesity and personalize treatment
20.04.2018 | Cedars-Sinai Medical Center
At the Hannover Messe 2018, the Bundesanstalt für Materialforschung und-prüfung (BAM) will show how, in the future, astronauts could produce their own tools or spare parts in zero gravity using 3D printing. This will reduce, weight and transport costs for space missions. Visitors can experience the innovative additive manufacturing process live at the fair.
Powder-based additive manufacturing in zero gravity is the name of the project in which a component is produced by applying metallic powder layers and then...
Physicists at the Laboratory for Attosecond Physics, which is jointly run by Ludwig-Maximilians-Universität and the Max Planck Institute of Quantum Optics, have developed a high-power laser system that generates ultrashort pulses of light covering a large share of the mid-infrared spectrum. The researchers envisage a wide range of applications for the technology – in the early diagnosis of cancer, for instance.
Molecules are the building blocks of life. Like all other organisms, we are made of them. They control our biorhythm, and they can also reflect our state of...
University of Connecticut researchers have created a biodegradable composite made of silk fibers that can be used to repair broken load-bearing bones without the complications sometimes presented by other materials.
Repairing major load-bearing bones such as those in the leg can be a long and uncomfortable process.
Study published in the journal ACS Applied Materials & Interfaces is the outcome of an international effort that included teams from Dresden and Berlin in Germany, and the US.
Scientists at the Helmholtz-Zentrum Dresden-Rossendorf (HZDR) together with colleagues from the Helmholtz-Zentrum Berlin (HZB) and the University of Virginia...
Novel highly efficient and brilliant gamma-ray source: Based on model calculations, physicists of the Max PIanck Institute for Nuclear Physics in Heidelberg propose a novel method for an efficient high-brilliance gamma-ray source. A giant collimated gamma-ray pulse is generated from the interaction of a dense ultra-relativistic electron beam with a thin solid conductor. Energetic gamma-rays are copiously produced as the electron beam splits into filaments while propagating across the conductor. The resulting gamma-ray energy and flux enable novel experiments in nuclear and fundamental physics.
The typical wavelength of light interacting with an object of the microcosm scales with the size of this object. For atoms, this ranges from visible light to...
13.04.2018 | Event News
12.04.2018 | Event News
09.04.2018 | Event News
25.04.2018 | Physics and Astronomy
25.04.2018 | Materials Sciences
25.04.2018 | Studies and Analyses