Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

VAI researchers develop tool to help study prostate cancer

12.03.2010
New model allows researchers to find differences in survival mechanisms for normal cells and cancer cells that could aid in developing treatments

Van Andel Research Institute (VARI) researchers have developed a new method to better study the cells that line and protect the prostate in relation to the development of cancer. Using the model, they found that normal cells and cancer cells depend on different factors to survive, which could aid in discovering how to target cancer cells without affecting normal cells when developing treatments.

Prostate cancer is the most common form of cancer in men, with more than 192,000 new cases and more than 27,000 deaths reported in the United States in 2009 (Source: National Cancer Institute).

"This new model will serve as a valuable tool for understanding secretory prostate epithelial cells, which until now have not been available for extensive analysis," said VARI Scientific Investigator Cindy Miranti, Ph.D., whose lab published its study in a recent issue of the Journal of Cell Science.

Epithelial cells line and protect the internal and external organs and structures of the body. The prostate contains two types of epithelial cells, basal and secretory, and prostate cancers arise from abnormal cells as they are converted from basal into secretory cells in the body.

Prior to this study, scientists were able to culture basal cells, but not secretory cells. Using the model, researchers found that, unlike cancer cells, normal secretory cells are not dependent on the male sex hormone androgen for survival, but are dependent for survival on binding to each other via the protein E-cadherin.

"Prostate cancers are dependent on androgen for survival, so we were interested in whether normal secretory prostate epithelial cells also depend on androgen," said Dr. Miranti. "However, the cell culture models available didn't allow us to study secretory cells, so we generated them by reconstructing the natural conversion process from basal into secretory cells in a petri dish."

The differences in how cancer cells and normal cells control their survival can be exploited to develop therapies that preferentially target the tumor cells, but not the normal cells.

"This cell model will be extremely useful to investigators who are interested in studying the cell biology of prostate cancer as well as benign prostate hyperplasia," said Donald J. Tindall, Ph.D., Professor, Director & Vice Chair of Urologic Research at the Mayo Clinic College of Medicine. "Such studies should facilitate our understanding of the cellular mechanisms involved in progression of these diseases and may lead to new prognostic capabilities and therapeutic interventions."

This work was supported by a Prostate Cancer Research Program Training Award from the Department of Defense Congressionally Directed Medical Research Programs (CDMRP) of the U.S. Army Medical Research and Materiel Command. Approximately 72% of this project has been funded by federal funds in the amount of $97,801. The remaining 28% has been contributed by Van Andel Research Institute in the approximate amount of $38,367. The content of the information does not necessarily reflect the position or policy of the U.S. Government, and no official endorsement should be inferred.

The work of VARI's Laboratory of Integrin Signaling and Tumorigenesis is also supported by Research Scholar Grant no. RSG-05-245-01-CSM from the American Cancer Society.

About Van Andel Institute

Established by Jay and Betty Van Andel in 1996, Van Andel Institute (VAI) is an independent research and educational organization based in Grand Rapids, Mich., dedicated to preserving, enhancing and expanding the frontiers of medical science, and to achieving excellence in education by probing fundamental issues of education and the learning process. VARI, the research arm of VAI, is dedicated to probing the genetic, cellular and molecular origins of cancer, Parkinson and other diseases and working to translate those findings into effective therapies. This is accomplished through the work of over 200 researchers in 18 on-site laboratories, in laboratories in Singapore and Nanjing, and in collaborative partnerships that span the globe.

Joe Gavan | EurekAlert!
Further information:
http://www.vai.org

More articles from Health and Medicine:

nachricht Penn vet research identifies new target for taming Ebola
12.01.2017 | University of Pennsylvania

nachricht The strange double life of Dab2
10.01.2017 | University of Miami Miller School of Medicine

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Designing Architecture with Solar Building Envelopes

Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.

As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...

Im Focus: How to inflate a hardened concrete shell with a weight of 80 t

At TU Wien, an alternative for resource intensive formwork for the construction of concrete domes was developed. It is now used in a test dome for the Austrian Federal Railways Infrastructure (ÖBB Infrastruktur).

Concrete shells are efficient structures, but not very resource efficient. The formwork for the construction of concrete domes alone requires a high amount of...

Im Focus: Bacterial Pac Man molecule snaps at sugar

Many pathogens use certain sugar compounds from their host to help conceal themselves against the immune system. Scientists at the University of Bonn have now, in cooperation with researchers at the University of York in the United Kingdom, analyzed the dynamics of a bacterial molecule that is involved in this process. They demonstrate that the protein grabs onto the sugar molecule with a Pac Man-like chewing motion and holds it until it can be used. Their results could help design therapeutics that could make the protein poorer at grabbing and holding and hence compromise the pathogen in the host. The study has now been published in “Biophysical Journal”.

The cells of the mouth, nose and intestinal mucosa produce large quantities of a chemical called sialic acid. Many bacteria possess a special transport system...

Im Focus: Newly proposed reference datasets improve weather satellite data quality

UMD, NOAA collaboration demonstrates suitability of in-orbit datasets for weather satellite calibration

"Traffic and weather, together on the hour!" blasts your local radio station, while your smartphone knows the weather halfway across the world. A network of...

Im Focus: Repairing defects in fiber-reinforced plastics more efficiently

Fiber-reinforced plastics (FRP) are frequently used in the aeronautic and automobile industry. However, the repair of workpieces made of these composite materials is often less profitable than exchanging the part. In order to increase the lifetime of FRP parts and to make them more eco-efficient, the Laser Zentrum Hannover e.V. (LZH) and the Apodius GmbH want to combine a new measuring device for fiber layer orientation with an innovative laser-based repair process.

Defects in FRP pieces may be production or operation-related. Whether or not repair is cost-effective depends on the geometry of the defective area, the tools...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

Nothing will happen without batteries making it happen!

05.01.2017 | Event News

 
Latest News

Multiregional brain on a chip

16.01.2017 | Power and Electrical Engineering

New technology enables 5-D imaging in live animals, humans

16.01.2017 | Information Technology

Researchers develop environmentally friendly soy air filter

16.01.2017 | Power and Electrical Engineering

VideoLinks
B2B-VideoLinks
More VideoLinks >>>