Human adenovirus type-3 is known as the “uncommon cold” because the infection’s symptoms—runny nose, sore throat, cough and fever—are eerily similar to those of the common cold which is caused by the rhinovirus. The difference is that, unlike the common cold, the symptoms of the uncommon cold are typically much more severe and can even be fatal.
Adenovirus-3 thrives in nations with dense urban populations and has recently become prevalent in southern China and neighboring countries. It may also emerge in less likely locales with dense populations, such as schools, health care facilities and military training bases in the U.S.
Determined to stamp out this devastating infection, researchers from George Mason University, the University of Hong Kong, Guangzhou Children’s Hospital, the South China Institute of Technology and the Graduate School of Chinese Academy of Sciences have developed a DNA-based vaccine that has effectively protected mice from the infection.
Their findings will appear in the February 18, 2009 print edition of the journal Vaccine and are currently available online.
“Further study is required, but we hope that in the future, this simple, stable and inexpensive vaccine can be mass-produced and made available to susceptible populations,” says Donald Seto, associate professor in George Mason University’s Department of Bioinformatics and Computational Biology, the only U.S.-based researcher involved in the study. “Affordability is a key factor since these regions are generally economically depressed.”
According to the Centers for Disease Control and Prevention (CDC), the human adenovirus was first seen in the 1950s and is associated with a wide spectrum of illnesses including conjunctivitis, upper respiratory infections, pneumonia and gastrointestinal disease. More than 50 unique serotypes of the virus have been identified, with even more expected to be isolated.
Adenovirus outbreaks are difficult to control because the virus can live for weeks on environmental surfaces and spreads quickly through direct contact, aerosol and contaminated drinking water.
Although the disease is relatively rare in the U.S., CDC records indicate that it has made several appearances here with devastating results. In 2000, four children died during an outbreak of adenovirus type-7 that occurred at a long-term care facility in Iowa, and nine patients died when adenovirus type-14 appeared as epidemics in Oregon, Texas and Washington in 2007.
Seto hopes that this new vaccine will serve as a model that allows his team to target the remaining strains of the virus.
“The immediate impact is the production and distribution of a low-cost, stable vaccine for adenovirus-3,” says Seto. “The outstanding question is, if all of the strains are so similar, why are they restricted to certain tissues, like only the eyes or the respiratory tract? That’s what we’ll try to figure out next.”
The paper was co-authored by Qiwei Zhang, Xiaobo Su, Bo-jian Zheng, Xingui Tian, Huiying Sheng, Haitao Li, Youshao Wang and Rong Zhou. The study was funded by the National Natural Science Foundation of China.About George Mason University
Marjorie Musick | EurekAlert!
Further reports about: > Adenovirus-3 > CDC > Cold > DNA-based vaccine > Human adenovirus type-3 > New Vaccine > Rhinovirus > Uncommon Cold Virus > Vaccine > Virus > adenovirus type-7 > conjunctivitis > contaminated drinking water > cough > devastating infection > fever > gastrointestinal disease > infection’s symptoms > information technology > pneumonia > respiratory infections > runny nose > sore throat
Routing gene therapy directly into the brain
07.12.2017 | Boston Children's Hospital
New Hope for Cancer Therapies: Targeted Monitoring may help Improve Tumor Treatment
01.12.2017 | Berliner Institut für Gesundheitsforschung / Berlin Institute of Health (BIH)
Tiny pores at a cell's entryway act as miniature bouncers, letting in some electrically charged atoms--ions--but blocking others. Operating as exquisitely sensitive filters, these "ion channels" play a critical role in biological functions such as muscle contraction and the firing of brain cells.
To rapidly transport the right ions through the cell membrane, the tiny channels rely on a complex interplay between the ions and surrounding molecules,...
The miniaturization of the current technology of storage media is hindered by fundamental limits of quantum mechanics. A new approach consists in using so-called spin-crossover molecules as the smallest possible storage unit. Similar to normal hard drives, these special molecules can save information via their magnetic state. A research team from Kiel University has now managed to successfully place a new class of spin-crossover molecules onto a surface and to improve the molecule’s storage capacity. The storage density of conventional hard drives could therefore theoretically be increased by more than one hundred fold. The study has been published in the scientific journal Nano Letters.
Over the past few years, the building blocks of storage media have gotten ever smaller. But further miniaturization of the current technology is hindered by...
With innovative experiments, researchers at the Helmholtz-Zentrums Geesthacht and the Technical University Hamburg unravel why tiny metallic structures are extremely strong
Light-weight and simultaneously strong – porous metallic nanomaterials promise interesting applications as, for instance, for future aeroplanes with enhanced...
An interdisciplinary group of researchers interfaced individual bacteria with a computer to build a hybrid bio-digital circuit - Study published in Nature Communications
Scientists at the Institute of Science and Technology Austria (IST Austria) have managed to control the behavior of individual bacteria by connecting them to a...
Physicists in the Laboratory for Attosecond Physics (run jointly by LMU Munich and the Max Planck Institute for Quantum Optics) have developed an attosecond electron microscope that allows them to visualize the dispersion of light in time and space, and observe the motions of electrons in atoms.
The most basic of all physical interactions in nature is that between light and matter. This interaction takes place in attosecond times (i.e. billionths of a...
11.12.2017 | Event News
08.12.2017 | Event News
07.12.2017 | Event News
11.12.2017 | Physics and Astronomy
11.12.2017 | Earth Sciences
11.12.2017 | Information Technology