UT Southwestern researchers uncover why ketamine produces a fast antidepressant response

The drug's robust effect at low doses as a fast-acting antidepressant potentially has use in emergency rooms with high-risk patients.

“Ketamine produces a very sharp increase that immediately relieves depression,” said Dr. Lisa Monteggia, associate professor of psychiatry at UT Southwestern and senior author of the study published June 15 in Nature.

Typical antidepressant medications – one of the most widely prescribed classes of drugs in the U.S. each year – often take several weeks to relieve symptoms of depression. If they are not successful within 12 weeks, physicians must prescribe a different antidepressant to produce a response.

“Ketamine produces a fast-acting antidepressant effect, and we hope our investigation provides critical information to treat depression effectively sooner,” Dr. Monteggia said.

“We now have a novel pathway to explore that may provide potential for the development of faster-acting and longer-lasting antidepressants,” Dr. Monteggia said.

The next step, Dr. Monteggia said, is to investigate further the short- and long-term effects of the changes that occur when the brain cells communicate with each other.

Other UT Southwestern researchers involved in the study were Anita Autry, student research assistant in psychiatry; Dr. Megumi Adachi, instructor in psychiatry; Dr. Elena Nosyreva, instructor in neuroscience; Dr. Elisa Na, postdoctoral researcher in psychiatry; Mr. Maarteen Los, visiting junior researcher in psychiatry; Mr. Peng-fei Cheng, formerly in psychiatry; and Dr. Ege Kavalali, professor of neuroscience and physiology.

The study was funded by the National Institute of Mental Health.

Visit http://www.utsouthwestern.org/neurosciences to learn more about UT Southwestern's clinical services in neurosciences, including psychiatry.

This news release is available on our World Wide Web home page at www.utsouthwestern.edu/home/news/index.html

To automatically receive news releases from UT Southwestern via email, subscribe at www.utsouthwestern.edu/receivenews

Media Contact

LaKisha Ladson EurekAlert!

More Information:

http://www.utsouthwestern.edu

All latest news from the category: Health and Medicine

This subject area encompasses research and studies in the field of human medicine.

Among the wide-ranging list of topics covered here are anesthesiology, anatomy, surgery, human genetics, hygiene and environmental medicine, internal medicine, neurology, pharmacology, physiology, urology and dental medicine.

Back to home

Comments (0)

Write a comment

Newest articles

Lighting up the future

New multidisciplinary research from the University of St Andrews could lead to more efficient televisions, computer screens and lighting. Researchers at the Organic Semiconductor Centre in the School of Physics and…

Researchers crack sugarcane’s complex genetic code

Sweet success: Scientists created a highly accurate reference genome for one of the most important modern crops and found a rare example of how genes confer disease resistance in plants….

Evolution of the most powerful ocean current on Earth

The Antarctic Circumpolar Current plays an important part in global overturning circulation, the exchange of heat and CO2 between the ocean and atmosphere, and the stability of Antarctica’s ice sheets….

Partners & Sponsors