Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Use of mood-stabilizing drug linked with reduced risk of developing head and neck cancer

24.03.2014

A new study indicates that a commonly used mood stabilizing drug may help prevent head and neck cancer. The study is published early online in Cancer, a peer-reviewed journal of the American Cancer Society.

Valproic acid (VPA) is currently prescribed as an anti-seizure medication and mood stabilizer, but it is also being studied as an anticancer agent because it inhibits histone acetyl transferases, which help control gene expression by changing DNA structure.

Johann Christoph Brandes MD, PhD, of the Atlanta Veterans Affairs Medical Center and Emory University in Atlanta, led a team that assessed the anticancer effects of VPA in a study of 439,628 veterans, of whom 26,911 were taking the medication for bipolar disorder, post-traumatic stress disorder, migraines, and seizures.

Veterans who took VPA for at least one year had a 34 percent lower risk of developing head and neck cancer compared with those who did not take the medication. Higher doses and longer duration of VPA use seemed to provide additional benefits.

No significant differences were observed for lung, bladder, colon, and prostate cancer incidences.

"A 34 percent risk reduction for the development of head and neck cancer with VPA use could result in the prevention of up to approximately 16,000 new cases and 3,000 to 4,000 annual deaths in the US alone," said Dr. Brandes.

"Head and neck cancer is an important global health crisis, and low cost and low toxicity prevention strategies like VPA use have a high potential impact on pain, suffering, costs, and mortality associated with this disease."

Evelyn Martinez | EurekAlert!
Further information:
http://www.wiley.com

Further reports about: DNA VPA anticancer bipolar differences disorder pain prostate reduction strategies toxicity

More articles from Health and Medicine:

nachricht First national study finds trees saving lives, reducing respiratory problems
28.07.2014 | USDA Forest Service - Northern Research Station

nachricht Kidney transplant drug halves the early risk of rejection and allows less toxic treatment
28.07.2014 | University of Oxford

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Anzeige

Anzeige

Event News

9th European Wood-Based Panel Symposium 2014 – meeting point for the wood-based material branch

24.07.2014 | Event News

“Lens on Life” - Artists and Scientists Explore Cell Divison

08.07.2014 | Event News

First International Conference on Consumer Research | ICCR 2014: Early bird deadline July 31, 2014

08.07.2014 | Event News

 
Latest News

Female bonobos start up early

28.07.2014 | Life Sciences

First national study finds trees saving lives, reducing respiratory problems

28.07.2014 | Health and Medicine

Kidney transplant drug halves the early risk of rejection and allows less toxic treatment

28.07.2014 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>