Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Uranium exposure linked to increased lupus rate

14.11.2012
People living near a former uranium ore processing facility in Ohio are experiencing a higher than average rate of lupus, according a new study conducted by scientists at the University of Cincinnati and Cincinnati Children's Hospital Medical Center.

Lupus is a chronic inflammatory disease that can affect the skin, joints, kidneys, lungs, nervous system and other organs of the body. The underlying causes of lupus are unknown, but it is usually more common in women of child-bearing age.

For this new study, a collaborative team of UC and Cincinnati Children's researchers wanted to compare lupus rates between people who were exposed to uranium and those who were not in an effort to explain the high number of lupus cases reported in a Cincinnati community.

Extensive review of medical records and serum antibody analysis to verify the cases, concluded that people who were exposed to higher levels of uranium, based on their living proximity to a former uranium ore processing plant, had lupus rates four times higher than the average population.

"Former studies have suggested that people with lupus may be more sensitive to radiation and that both genetics and environmental exposures play a role in disease development. Our study shows a strong correlation between uranium exposure, a radioactive substance, and an increased lupus rate that merits further investigation," says Pai-Yue Lu, MD, a pediatric rheumatology fellow at Cincinnati Children's and lead researcher for the study.

"With more research in this area, we may gain additional insight on the types of environmental factors that contribute to lupus development and the mechanisms by which they work," Lu adds. "There could be other effects of uranium and related exposures that could contribute to or help explain our findings."

Lu is presenting this finding and its potential implication at the American College of Rheumatology Annual Scientific Meeting Monday, Nov. 12, in Washington, D.C. She completed the project as part of her master's degree in clinical and translational science training at UC.

The Cincinnati-based team's research is based on nearly two decades of data collected through the Fernald Medical Monitoring Program, the United States' first and largest legally mandated comprehensive medical monitoring program. The program was established in 1990 after a federal investigation revealed that National Lead of Ohio's Feed Materials Production Center in the Hamilton County, Ohio, community of Fernald, was emitting dangerous levels of uranium dust and gases into the surrounding communities.

"The availability of this cohort and carefully collected data and biospecimens provides a great setting to ask research questions," says Susan Pinney, PhD, UC professor of environmental health and principal investigator of the Fernald study.

Almost 10,000 community residents enrolled in the Fernald Medical Monitoring Program. Community residents were classified into several exposure groups: high exposure, moderate exposure, low exposure and no exposure. (Uranium plant workers were not part of this study.)

"Typical U.S. incidence rates for lupus are 1.8 to 7.6 cases per 100,000. Among the 25 confirmed lupus cases we identified through the Fernald community cohort, 12 were in the high exposure group, eight with moderate exposure and five in the low exposure group," says Lu.

Research was supported by a pilot grant from a Center for Environmental Genetics, a National Institute of Environmental Health Sciences-funded program to support core facilities and technologies needed to conduct innovative research that focuses on how environmental agents interact with genetic and epigenetic factors to influence disease risk and outcome. Shuk-mei Ho, PhD, Jacob A. Schmidlapp Chair and Professor of Environmental Health, serves as principal investigator of the CEG grant.

Amanda Harper | EurekAlert!
Further information:
http://www.uc.edu

More articles from Health and Medicine:

nachricht NTU scientists build new ultrasound device using 3-D printing technology
07.12.2016 | Nanyang Technological University

nachricht How to turn white fat brown
07.12.2016 | University of Pennsylvania School of Medicine

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Significantly more productivity in USP lasers

In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.

Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...

Im Focus: Shape matters when light meets atom

Mapping the interaction of a single atom with a single photon may inform design of quantum devices

Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

Im Focus: MADMAX: Max Planck Institute for Physics takes up axion research

The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.

The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

NTU scientists build new ultrasound device using 3-D printing technology

07.12.2016 | Health and Medicine

The balancing act: An enzyme that links endocytosis to membrane recycling

07.12.2016 | Life Sciences

How to turn white fat brown

07.12.2016 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>