Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Umeå researchers even closer to early detection of Parkinson’s disease

26.09.2012
In collaboration with colleagues at Oxford, a team of researchers at Umeå University in Sweden has now further elaborated its discovery of a way to detect Parkinson’s disease at an early stage, and applications in clinical care are not far away.
The project is an example of bridging the gap between basic and clinical research in care environments. The new findings are based on close cooperation between the medical chemist Ludmilla Morozova-Roche’s and the neurologist Lars Forsgren’s research teams at Umeå University and Jason Davis's team at Oxford University in the UK, who were primarily responsible for the chemical analyses. Their findings are now being published in the journal Chemical Science.

Parkinson’s disease attacks the nervous system and, like many other diseases, is caused by proteins that lump together into so-called amyloid. Behind these new findings lies a discovery from the spring of 2011, when the Umeå scientists were able to determine endogenous antibodies against the most important amyloid protein, alpha-synuclein. These antibodies were seen as being able to function as a diagnostic marker, thereby enabling early detection of the disease.

In the new article the discovery is elaborated further in the form of a simplified way to carefully measure the content of antibodies in a blood sample. With the newly developed method – this involves electrochemical analysis of 10 microliters of blood in just a few minutes – it is possible not only to see a clear difference between individuals with incipient Parkinson’s disease and healthy controls but also to measure and establish the advance of the disease with great precision.

Press photo of Ludmilla Morozova-Roche
For more information, please contact:

Ludmilla Morozova-Roche, professor of medical biophysics at the Department of Medical Chemistry and Biophysics, Umeå University, phone: +46 (0)90-786 52 83, Mobile: +46 (0)73-620 52 83
E-mail ludmilla.morozova-roche@medchem.umu.se
Reference

T Bryan, X Luo, L Forsgren, L Morozova-Roche and JJ Davis. The robust electrochemical detection of a Parkinson’s disease marker in whole blood sera

Chemical Science, DOI: 10.1039/c2sc21221h

Karin Wikman | idw
Further information:
http://www.rsc.org/chemicalscience
http://pubs.rsc.org/en/content/articlepdf/2012/sc/c2sc21221h?page=search

More articles from Health and Medicine:

nachricht Researchers identify early sign of pancreatic cancer
29.09.2014 | Dana-Farber Cancer Institute

nachricht Scientists discover a new role for estrogen in the pathology of breast cancer
29.09.2014 | University of Illinois at Urbana-Champaign

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Anzeige

Anzeige

Event News

BrainScaleS Conference: From Neurobiology to New Computer Architectures

25.09.2014 | Event News

17th European Health Forum Gastein: “Electing Health – The Europe We Want”

23.09.2014 | Event News

Future questions regarding data processing

22.09.2014 | Event News

 
Latest News

'Deadly diarrhea' rates nearly doubled in 10 years: Study

30.09.2014 | Studies and Analyses

Newborn Tropical Storm Phanfone triggers warnings in Northwestern Pacific

30.09.2014 | Earth Sciences

Modeling shockwaves through the brain

30.09.2014 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>