Acute coronary syndromes, such as myocardial infarction and unstable angina, are among the most common causes of emergency medical care and death in Sweden for both women and men.
"The ability to predict the future course of the syndrome in a patient may improve the possibility of providing extra preventative treatment for those with the highest risks. Or, and this may be more important, the possibility of following these patients with more frequent check ups in order to detect early whether the patient's health is deteriorating", says biomedical scientist, Anita Persson.
The study on which the thesis is based showed that elevated levels of B-type natriuretic peptide (BNP) in the blood were associated not only with an impaired ability of the heart to pump blood, but also with the risk of rehospitalisation due to heart failure following acute coronary syndromes, and premature death. One noteworthy finding was that the correlation between high BNP and future risk was present also for those patients who did not show signs of heart failure during the first acute episode.
The other method that Anita Persson has evaluated is the use of ultrasound, in a technique known as "Doppler echocardiography", to assess leakage at one of the valves in the heart. It proved to be the case that the ultrasound investigation can predict not only increased mortality but also increased rehospitalisation due to heart failure.
She found, by comparing many different properties of the function of the heart determined by Doppler echocardiography, that an increased volume of the left ventricle and increased pressure during the filling phase of the heart action or increased stiffness of the ventricle were associated with a poorer prognosis and an increased risk of complications.The study is based on a large group of patients with acute coronary syndromes who received care between September 1995 and March 2001 in the Coronary Care Unit at Sahlgrenska University Hospital. "Including the echocardiography variables on their own or in combination with the level of BNP in the risk assessment can be a relatively simple means of identifying high-risk patients and those who have the best preconditions for avoiding
complications", says Anita Persson.
The complete thesis can be downloaded from: http://hdl.handle.net/2077/23716For more information:
Organ-on-a-chip mimics heart's biomechanical properties
23.02.2017 | Vanderbilt University
Researchers identify cause of hereditary skeletal muscle disorder
22.02.2017 | Klinikum der Universität München
On January 15, 2009, Chesley B. Sullenberger was celebrated world-wide: after the two engines had failed due to bird strike, he and his flight crew succeeded after a glide flight with an Airbus A320 in ditching on the Hudson River. All 155 people on board were saved.
On January 15, 2009, Chesley B. Sullenberger was celebrated world-wide: after the two engines had failed due to bird strike, he and his flight crew succeeded...
Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...
The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.
The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...
Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...
13.02.2017 | Event News
10.02.2017 | Event News
09.02.2017 | Event News
27.02.2017 | Materials Sciences
27.02.2017 | Interdisciplinary Research
27.02.2017 | Life Sciences