Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

UK Study Shows Potential New Way to Detect Colorectal and Other Cancers

26.04.2013
A unique new study led by University of Kentucky Markey Cancer Center researchers Guo-Min Li and Libya Gu, in collaboration with Dr. Wei Yang at National Institutes of Health, reveals a novel mechanism explaining the previously unknown root cause of some forms of colorectal cancers.

The study, published in Cell, discovers that an abnormal histone protein modification impairs a DNA repair machinery that controls cancer development, yielding a potential new way of detecting these types of colorectal cancers. It represents the first time that epigenetic histone marks regulate the genome maintenance system.

DNA errors created during DNA replication can lead to many forms of cancer, including colorectal cancer. Cells possess DNA mismatch repair (MMR) machinery that aids in correcting these errors, thus preventing disease development. Defects in MMR genes lead to development of colorectal cancers characterized by frequent alterations in simple repetitive DNA sequences, a phenomenon referred to as microsatellite instability (MSI). Some cancers develop in individuals who possess MSI without MMR gene defects, and until now, the reason for this has been unknown.

Dr. Li’s study shows that defects in SETD2 – an enzyme that is not involved in MMR but chemically or epigenetically modifies histone proteins associated with DNA that control the regulation of gene expression and DNA replication – prevent the association of MMR proteins with damaged DNA, thus preventing DNA mismatch repair.

"This study provides new clues to cancer etiology, that is, from the classical genetic defects to abnormal epigenetic modifications in the future," Li said. "Since SETD2 mutations have been shown in many types of cancers, including clear cell renal cell carcinoma, lung cancer, gastric cancer and hematological malignancies, our next goal is to determine association of MMR defects with these cancers, as well as SETD2 mutations in MSI-positive MMR-competent colorectal cancers."

Although most colorectal cancers are preventable or treatable with proper screening, colorectal cancer remains the second-leading cause of cancer death in the United States. Kentucky is ranked in the highest tiers for both colorectal and lung cancer incidence and death.

MEDIA CONTACT: Allison Perry, (859) 323-2399 or allison.perry@uky.edu

Allison Perry | EurekAlert!
Further information:
http://www.uky.edu

More articles from Health and Medicine:

nachricht Correct connections are crucial
26.06.2017 | Charité - Universitätsmedizin Berlin

nachricht One gene closer to regenerative therapy for muscular disorders
01.06.2017 | Cincinnati Children's Hospital Medical Center

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Can we see monkeys from space? Emerging technologies to map biodiversity

An international team of scientists has proposed a new multi-disciplinary approach in which an array of new technologies will allow us to map biodiversity and the risks that wildlife is facing at the scale of whole landscapes. The findings are published in Nature Ecology and Evolution. This international research is led by the Kunming Institute of Zoology from China, University of East Anglia, University of Leicester and the Leibniz Institute for Zoo and Wildlife Research.

Using a combination of satellite and ground data, the team proposes that it is now possible to map biodiversity with an accuracy that has not been previously...

Im Focus: Climate satellite: Tracking methane with robust laser technology

Heatwaves in the Arctic, longer periods of vegetation in Europe, severe floods in West Africa – starting in 2021, scientists want to explore the emissions of the greenhouse gas methane with the German-French satellite MERLIN. This is made possible by a new robust laser system of the Fraunhofer Institute for Laser Technology ILT in Aachen, which achieves unprecedented measurement accuracy.

Methane is primarily the result of the decomposition of organic matter. The gas has a 25 times greater warming potential than carbon dioxide, but is not as...

Im Focus: How protons move through a fuel cell

Hydrogen is regarded as the energy source of the future: It is produced with solar power and can be used to generate heat and electricity in fuel cells. Empa researchers have now succeeded in decoding the movement of hydrogen ions in crystals – a key step towards more efficient energy conversion in the hydrogen industry of tomorrow.

As charge carriers, electrons and ions play the leading role in electrochemical energy storage devices and converters such as batteries and fuel cells. Proton...

Im Focus: A unique data centre for cosmological simulations

Scientists from the Excellence Cluster Universe at the Ludwig-Maximilians-Universität Munich have establised "Cosmowebportal", a unique data centre for cosmological simulations located at the Leibniz Supercomputing Centre (LRZ) of the Bavarian Academy of Sciences. The complete results of a series of large hydrodynamical cosmological simulations are available, with data volumes typically exceeding several hundred terabytes. Scientists worldwide can interactively explore these complex simulations via a web interface and directly access the results.

With current telescopes, scientists can observe our Universe’s galaxies and galaxy clusters and their distribution along an invisible cosmic web. From the...

Im Focus: Scientists develop molecular thermometer for contactless measurement using infrared light

Temperature measurements possible even on the smallest scale / Molecular ruby for use in material sciences, biology, and medicine

Chemists at Johannes Gutenberg University Mainz (JGU) in cooperation with researchers of the German Federal Institute for Materials Research and Testing (BAM)...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Plants are networkers

19.06.2017 | Event News

Digital Survival Training for Executives

13.06.2017 | Event News

Global Learning Council Summit 2017

13.06.2017 | Event News

 
Latest News

Study shines light on brain cells that coordinate movement

26.06.2017 | Life Sciences

Smooth propagation of spin waves using gold

26.06.2017 | Physics and Astronomy

Switchable DNA mini-machines store information

26.06.2017 | Information Technology

VideoLinks
B2B-VideoLinks
More VideoLinks >>>