Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Type 1 diabetes in young children: soluble fiber intake has no preventive effect

21.07.2015

The search for a food component that protects against type 1 diabetes continues. Analyses conducted by the international TEDDY (The Environmental Determinants of Diabetes in the Young) study suggest that the intake of soluble dietary fiber has no protective effect on the immune system or the microbiome.

A low-fiber diet is considered to be a potential trigger for such diseases as colon cancer and irritable bowel syndrome arising from inflammatory processes or an autoimmune re-sponse. Scientists at the Institute of Diabetes Research and the Forschergruppe Diabetes e. V., examined whether, conversely, a fiber-rich diet – particularly one that has a high content of soluble fiber – could prevent the autoimmune disease type 1 diabetes.

To this end, they analyzed over 17,600 food records from more than 3,300 children from Germany and the United States who took part in the TEDDY study. The records were kept at regular intervals, when the children were between nine and 48 months of age.

The children’s islet autoantibody status was checked every three months. When one or multiple islet autoantibodies are detected in the blood, this is referred to as islet autoimmunity. If multiple islet autoantibodies are found, almost 100 percent of the individuals concerned will go on to develop type 1 diabetes within 20 years.

Can soluble fiber protect against islet autoimmunity?

When soluble fibers are digested in the gut, they undergo fermentation, which produces short-chain fatty acids, to which anti-inflammatory properties are ascribed. In addition, there are indications that fibers affect the composition of the intestinal flora. The micro-organisms that inhabit the bowel, meanwhile, interact with the immune system.

Current studies indicate that the microbiome of individuals with type 1 diabetes differs from that of healthy individuals. The diabetes researchers from Munich therefore assumed that a high intake of soluble fiber in the first two years of life could protect against the development of islet autoimmunity. Most cases of islet autoimmunity occur at this stage in life.

Unfortunately no evidence was found to support this assumption. At no stage in early childhood could a statistically significant connection be established between the amount of high-fiber food ingested and a later onset of islet autoimmunity or an earlier manifestation of type 1 diabetes.

“Our analyses lead us to conclude that an insufficient intake of fiber has no direct effect on inflammatory processes in the body that lead to type 1 diabetes,” says Dr. Andreas Beyerlein, a statistician at the Institute of Diabetes Research, summarizing the results.

“We are still a long way off from making dietary recommendations for preventing type 1 diabetes in high-risk individuals,” adds Dr. Beyerlein’s colleague, Dr. Sandra Hummel, who is a nutritional scientist. “It may be that other food components influence the microbiome and the development of autoimmunity.” Given the still relatively short follow-up time for participants in the TEDDY study (median follow-up = five years) long-term effects cannot, however, be ruled out.

The TEDDY Study is funded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institute of Allergy and Infectious Diseases (NIAID), National Institute of Child Health and Human Development (NICHD), National Institute of Environmental Health Sciences (NIEHS), Juvenile Diabetes Research Foundation (JDRF), and Centers for Disease Control and Prevention (CDC).

Publication:
Andreas Beyerlein, Xiang Liu, Ulla M Uusitalo, Minna Harsunen, Jill M Norris, Kristina Foterek, Suvi M Virtanen, Marian J Rewers, Jin-Xiong She, Olli Simell, Åke Lernmark, William Hagopian, Beena Akolkar, Anette-G Ziegler, Jeffrey P Krischer, Sandra Hummel, and the TEDDY study group. Dietary intake of soluble fiber and risk of islet autoimmunity by 5 y of age: results from the TEDDY study Am J Clin Nutr ajcn108159; First published online July 8, 2015. doi:10.3945/ajcn.115.108159

Claudia Pecher | Forschergruppe Diabetes der Technischen Universität München
Further information:
http://www.kompetenznetz-diabetes-mellitus.net

More articles from Health and Medicine:

nachricht One gene closer to regenerative therapy for muscular disorders
01.06.2017 | Cincinnati Children's Hospital Medical Center

nachricht The gut microbiota plays a key role in treatment with classic diabetes medication
01.06.2017 | University of Gothenburg

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Can we see monkeys from space? Emerging technologies to map biodiversity

An international team of scientists has proposed a new multi-disciplinary approach in which an array of new technologies will allow us to map biodiversity and the risks that wildlife is facing at the scale of whole landscapes. The findings are published in Nature Ecology and Evolution. This international research is led by the Kunming Institute of Zoology from China, University of East Anglia, University of Leicester and the Leibniz Institute for Zoo and Wildlife Research.

Using a combination of satellite and ground data, the team proposes that it is now possible to map biodiversity with an accuracy that has not been previously...

Im Focus: Climate satellite: Tracking methane with robust laser technology

Heatwaves in the Arctic, longer periods of vegetation in Europe, severe floods in West Africa – starting in 2021, scientists want to explore the emissions of the greenhouse gas methane with the German-French satellite MERLIN. This is made possible by a new robust laser system of the Fraunhofer Institute for Laser Technology ILT in Aachen, which achieves unprecedented measurement accuracy.

Methane is primarily the result of the decomposition of organic matter. The gas has a 25 times greater warming potential than carbon dioxide, but is not as...

Im Focus: How protons move through a fuel cell

Hydrogen is regarded as the energy source of the future: It is produced with solar power and can be used to generate heat and electricity in fuel cells. Empa researchers have now succeeded in decoding the movement of hydrogen ions in crystals – a key step towards more efficient energy conversion in the hydrogen industry of tomorrow.

As charge carriers, electrons and ions play the leading role in electrochemical energy storage devices and converters such as batteries and fuel cells. Proton...

Im Focus: A unique data centre for cosmological simulations

Scientists from the Excellence Cluster Universe at the Ludwig-Maximilians-Universität Munich have establised "Cosmowebportal", a unique data centre for cosmological simulations located at the Leibniz Supercomputing Centre (LRZ) of the Bavarian Academy of Sciences. The complete results of a series of large hydrodynamical cosmological simulations are available, with data volumes typically exceeding several hundred terabytes. Scientists worldwide can interactively explore these complex simulations via a web interface and directly access the results.

With current telescopes, scientists can observe our Universe’s galaxies and galaxy clusters and their distribution along an invisible cosmic web. From the...

Im Focus: Scientists develop molecular thermometer for contactless measurement using infrared light

Temperature measurements possible even on the smallest scale / Molecular ruby for use in material sciences, biology, and medicine

Chemists at Johannes Gutenberg University Mainz (JGU) in cooperation with researchers of the German Federal Institute for Materials Research and Testing (BAM)...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Plants are networkers

19.06.2017 | Event News

Digital Survival Training for Executives

13.06.2017 | Event News

Global Learning Council Summit 2017

13.06.2017 | Event News

 
Latest News

Quantum thermometer or optical refrigerator?

23.06.2017 | Physics and Astronomy

A 100-year-old physics problem has been solved at EPFL

23.06.2017 | Physics and Astronomy

Equipping form with function

23.06.2017 | Information Technology

VideoLinks
B2B-VideoLinks
More VideoLinks >>>