Medical physicists at Thomas Jefferson University and Jefferson's Kimmel Cancer Center are one step closer to bringing a new tumor-tracking technique into the clinic that delivers higher levels of radiation to moving tumors, while sparing healthy tissue in lung cancer patients.
Evidence has shown a survival advantage for lung cancer patients treated with higher doses of radiation. Therefore, there is an increased interest to find novel ways to better track tumors—which are in constant motion because of breathing—in order to up the dosage during radiation therapy without increasing harmful side effects
After proving its success in simulations, researchers have now shown that their real-time tracking technique can achieve such tasks. Not only can it better predict and track tumor motion and deliver higher levels of radiation to lung cancer patients and others with moving tumor targets, it can also successfully be implemented into existing clinical equipment (i.e., Elekta Precise Table).
The results of the study, led by Ivan Buzurovic, Ph.D., a medical physics resident and researcher in the Department of Radiation Oncology at Thomas Jefferson University, and Yan Yu, Ph.D., Professor, Vice Chair and Director of Medical Physics at Thomas Jefferson University, were published in the November issue of Medical Physics.
"We've shown here that our system can better predict and continuously track moving tumors during radiotherapy, preventing unnecessary amounts of radiation from being administered to unnecessary areas," said Dr. Buzurovic. "Just as important, we've successfully modified existing technology to integrate with the system to perform the tracking and delivery, meaning no additional robotic systems is needed."
Respiratory and cardiac motions have been found to displace and deform tumors in the lung and other organs. Because of this, radiation oncologists must expand the margin during radiotherapy, and consequently a large volume of healthy tissue is irradiated, and critical organs adjacent to the tumor are sometimes difficult to spare.
In an effort to shrink that margin, Jefferson researchers developed a new, robotic technique that better tracks tumor motion to deliver more precise radiation.
Here, the researchers applied a new control system (software and hardware) and robotic technology to existing treatment couches used for radiation therapy to determine the tracking technology's feasibility in a clinical setting.
They found the technology can be integrated onto treatment couches and validated the tumor tracking system capabilities to follow desired trajectories. When the active tracking system was applied, irradiated planning target volume (the area set for treatment) was 20 to 30 percent less for medium size tumors and more than 50 percent for small size tumors.
"The use of tumor tracking technology during radiotherapy treatment for lung cancer would result in significant reduction in dose to critical organs and tissue, potentially decreasing the probability or severity of side effects, and thus improving cancer treatments," Dr. Yu said.
Based on these results, it can be hypothesized that clinical implementation of real-time tracking is feasible for achieving potentially improved patient outcome.
"With this new technique, it shrinks the margin, and radiation oncologists would be able to administer more radiation and faster to the tumor than conventional methods," said Adam P. Dicker, M.D, Ph.D., Professor and Chairman of the Department of Radiation Oncology at Thomas Jefferson University. "And a higher, more targeted dose means a better cure in lung cancer."
Steve Graff | EurekAlert!
Antibiotic effectiveness imperiled as use in livestock expected to increase
27.03.2015 | Princeton University
A human respiratory tissue model to assess the toxicity of inhaled chemicals and pollutants
26.03.2015 | R&D at British American Tobacco
In an experiment at the Department of Energy's SLAC National Accelerator Laboratory, scientists precisely measured the temperature and structure of aluminum as...
The IPH presents a solution at HANNOVER MESSE 2015 to make ship traffic more reliable while decreasing the maintenance costs at the same time. In cooperation with project partners, the research institute from Hannover, Germany, has developed a sensor system which continuously monitors the condition of the marine gearbox, thus preventing breakdowns. Special feature: the monitoring system works wirelessly and energy-autonomously. The required electrical power is generated where it is needed – directly at the sensor.
As well as cars need to be certified regularly (in Germany by the TÜV – Technical Inspection Association), ships need to be inspected – if the powertrain stops...
When an earthquake hits, the faster first responders can get to an impacted area, the more likely infrastructure--and lives--can be saved.
The Atlantic overturning is one of Earth’s most important heat transport systems, pumping warm water northwards and cold water southwards. Also known as the Gulf Stream system, it is responsible for the mild climate in northwestern Europe.
Scientists now found evidence for a slowdown of the overturning – multiple lines of observation suggest that in recent decades, the current system has been...
Because they are regularly subjected to heavy vehicle traffic, emissions, moisture and salt, above- and underground parking garages, as well as bridges, frequently experience large areas of corrosion. Most inspection systems to date have only been capable of inspecting smaller surface areas.
From April 13 to April 17 at the Hannover Messe (hall 2, exhibit booth C16), engineers from the Fraunhofer Institute for Nondestructive Testing IZFP will be...
25.03.2015 | Event News
19.03.2015 | Event News
17.03.2015 | Event News
27.03.2015 | Agricultural and Forestry Science
27.03.2015 | Materials Sciences
27.03.2015 | Ecology, The Environment and Conservation