Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Tuberculosis: On the path to prevention

01.12.2009
Researchers at the MUHC and their international colleagues have identified the first genetic resistance factor against tuberculosis infection

Why do some people who are exposed to tuberculosis not become infected or develop the disease? Dr. Erwin Schurr and his team at the Research Institute from the McGill University Health Centre (RI-MUHC), in collaboration with Dr. Alexandre Alcais, from the Institut national de la santé et de la recherche médicale (INSERM) in Paris, has shed light on this question for the first time. Their results show that one or multiple genes might provide certain people with resistance to tuberculosis infection. Their findings are published in the Journal of Experimental Medicine.

Tuberculosis (TB) is an infectious disease caused by a bacterium called Mycobacterium tuberculosis (MTB). Two thirds of the world population are infected by this mycobacterium. Nevertheless, 20 per cent of people exposed to the mycobacterium are resistant to infection and can therefore, not develop the disease. " For our study, we were interested in this minority of people who live in high-exposure areas without becoming infected," said Dr. Schurr. "We tried to understand how these people develop resistance to TB infection."

Their findings show the existence of a chromosomal site, or a locus, that controls resistance to TB infection. Out of the 128 families studied, who come from an area in South Africa with high tuberculosis rates, after considering non genetic factors such as age, 20 per cent of individuals show natural resistance. "In other words, some people seem to have a particular genetic heritage that makes them naturally resistant to MTB infection," explained Dr. Alcais.

"The discovery of a genetic resistance factor is a major step forward in the fight against TB both locally and globally," said Dr. Schurr. This is a major development for people with HIV, for whom tuberculosis is a leading cause of mortality, as it is responsible for about 13% of AIDS-related deaths in the world. "Since they accelerate each other's progress, HIV and tuberculosis are partners in crime; if we can prevent infection, immune deficient patients will no longer be threatened by TB," stated Dr. Schurr.

"Right now, our challenge as researchers is to concentrate on identifying this genetic factor and its mechanisms that lead to resistance against TB infection," explained Dr. Alcais. The hope is that these genetic resistance factors can be used in the near future to prevent TB infection in the general population by stimulating the mechanism responsible for resistance.

"If we can make everyone resistant to tuberculosis infection, this major public health problem could be wiped off the map," concluded Dr. Schurr.

Dr. Erwin Schurr is a researcher at the Centre for the Study of Host Resistance at the Research Institue of the MUHC and a molecular geneticist at the Department of Human Genetics at the McGill Faculty of Medicine, McGill University

Dr. Alcais is a researcher at the Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale, France, University Paris Descartes, Necker Medical School, France, Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, USA.

Funding

This study was funded by a grant from the Canadian Institutes for Health Research (CIHR), Sequella/AERAS Global Tuberculosis Vaccine Foundation, and the Gates Foundation. Some authors received financial support from Fonds de la recherche en santé du Québec (FRSQ).

Partners

This article was co-authored by Caroline Gallant, Leah Simkin and Erwin Schurr from RI MUHC, Aurelie Cobat from INSERM U550, Paris, France; Jean-Laurent Casanova, Laurent Abel and Alexandre Alcais from INSERM U550, Université Paris Descartes, Paris, France and Laboratory of Human Genetics, The Rockefeller University, NYC, U.S.A; Ann Boland-Auge, Centre National de Génotypage, Evry, France, Mark Doherty, Statens Serum Institute, Copenhagen, Danemark, Gillian Black, Kim Stanley, Paul van Helden and Eileen Hoal, Stellenbosch University, Tygerberg, South Africa, Jane Hughes, Brian Eley, and Willem Hanekom, University of Cape Town, Cape Town, South Africa.

You will find this press release, with the original article and a short audio interview by following this link: http://www.muhc.ca/media/news/

The Research Institute of the McGill University Health Centre (RI MUHC) is a world-renowned biomedical and health-care hospital research centre. Located in Montreal, Quebec, the institute is the research arm of the MUHC, the university health center affiliated with the Faculty of Medicine at McGill University. The institute supports over 600 researchers, nearly 1200 graduate and post-doctoral students and operates more than 300 laboratories devoted to a broad spectrum of fundamental and clinical research. The Research Institute operates at the forefront of knowledge, innovation and technology and is inextricably linked to the clinical programs of the MUHC, ensuring that patients benefit directly from the latest research-based knowledge.

The Research Institute of the MUHC is supported in part by the Fonds de la recherche en santé du Québec. For further details visit: www.muhc.ca/research

The McGill University Health Centre (MUHC) is a comprehensive academic health institution with an international reputation for excellence in clinical programs, research and teaching. Its partner hospitals are the Montreal Children's Hospital, the Montreal General Hospital, the Royal Victoria Hospital, the Montreal Neurological Hospital, the Montreal Chest Institute and the Lachine Hospital. The goal of the MUHC is to provide patient care based on the most advanced knowledge in the health care field and to contribute to the development of new knowledge. www.muhc.ca

About the MUHC Redevelopment Project Guided by its mission and its role as co-leaders of the McGill integrated university hospital network, the MUHC is carrying out a $2.2-billion Redevelopment Project that will help the Government achieve its vision for academic medicine in Quebec. Excellence in patient care, research, education and technology assessment will be fostered on three state-of-the-art campuses—The Mountain, the Glen and Lachine—and through strong relationships with healthcare partners. Each LEED®-registered campus will be designed to provide patients and their families with "The Best Care for Life" in a healing environment that is anchored in best sustainable development practices, including BOMA BESt guidelines. www.muhc.ca/construction

For more information please contact:
Julie Robert
Communications Coordinator (research)
Public Affairs & Strategic Planning
(514) 843 1560
julie.robert@muhc.mcgill.ca

Julie Robert | EurekAlert!
Further information:
http://www.muhc.mcgill.ca

More articles from Health and Medicine:

nachricht A promising target for kidney fibrosis
21.04.2017 | Brigham and Women's Hospital

nachricht Stem cell transplants: activating signal paths may protect from graft-versus-host disease
20.04.2017 | Technische Universität München

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Making lightweight construction suitable for series production

More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.

Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...

Im Focus: Wonder material? Novel nanotube structure strengthens thin films for flexible electronics

Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.

"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...

Im Focus: Deep inside Galaxy M87

The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.

Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...

Im Focus: A Quantum Low Pass for Photons

Physicists in Garching observe novel quantum effect that limits the number of emitted photons.

The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...

Im Focus: Microprocessors based on a layer of just three atoms

Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.

Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Expert meeting “Health Business Connect” will connect international medical technology companies

20.04.2017 | Event News

Wenn der Computer das Gehirn austrickst

18.04.2017 | Event News

7th International Conference on Crystalline Silicon Photovoltaics in Freiburg on April 3-5, 2017

03.04.2017 | Event News

 
Latest News

Early organic carbon got deep burial in mantle

25.04.2017 | Earth Sciences

A room with a view - or how cultural differences matter in room size perception

25.04.2017 | Life Sciences

Warm winds: New insight into what weakens Antarctic ice shelves

25.04.2017 | Earth Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>